Identification and Distribution of Arachidonic Acid Metabolites in the Human Gastrointestinal Tract, and the Ways in Which Some of these Affect the Longitudinal Muscle

  • Alan Bennet
  • Christopher N. Hensby
  • Gareth J. Sanger
  • Ian F. Stamford
Part of the NATO Advanced Study Institutes Series book series


Prostaglandins (PGs) may have various roles in gastrointestinal function. They have also been implicated as contributors to various gastrointestinal diseases, including gastritis, gastric ulcer formation, ulcerative colitis, irritable bowel syndrome, idiopathic intestinal pseudo-obstruction, food intolerance, and radiation-induced and other forms of diarrhoea (1–8). In contrast, PGs administered as drugs may be useful in the treatment of peptic ulceration, prevention of aspirin- or indomethacin-induced gastric mucosal damage (9) and reversal of post-operative ileus (10). Knowledge of the types of compounds formed from the C20-unsaturated fatty acids eicosatrienoic, eicosatetraenoic (arachidonic) and eicosapentaenoic acids, and their actions on the human gut, is therefore important. Most studies to date have concerned PGE and PGFα compounds, but we have now extended this to include other metabolites of arachidonic acid.


Arachidonic Acid Irritable Bowel Syndrome Terminal Ileum Longitudinal Muscle Krebs Solution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Alan Bennet
    • 1
    • 2
  • Christopher N. Hensby
    • 1
    • 2
  • Gareth J. Sanger
    • 1
    • 2
  • Ian F. Stamford
    • 1
    • 2
  1. 1.Department of SurgeryKing’s College Hospital Medical SchoolLondonEngland
  2. 2.Department of Clinical PharmacologyRoyal Postgraduate Medical SchoolLondonEngland

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