Action of Prostaglandins and Other Arachidonic Acid Metabolites on Airway Function

  • M. F. Cuthbert
  • P. J. Gardiner
Part of the NATO Advanced Study Institutes Series book series


The prostaglandins were first isolated from the lungs by Bergstrom and his co-workers in 1962 (1). More recently other metabolites of arachidonic acid have also been isolated from the lungs, namely, thromboxanes (2,3) and prostacyclin (4). It is now established that the prostaglandins, thromboxanes and prostacyclin (prostanoids) have powerful effects on both respiratory and vascular smooth muscle and that the lungs have an important function in their metabolic degradation. The most important enzyme in this respect is 15-prostaglandin dehydrogenase and some 90% of most infused prostaglandins except the PGA’s and PGI2 are removed in a single passage through the pulmonary circulation in both animals and man (5,6). It is understandable that these findings have led to considerable speculation on the possible physiological and pathological role of the prostanoids on respiratory function and has raised the possibility that prostaglandins of the E series or their metabolites, or substances that interfere with the synthesis of action of the prostanoids, might be of therapeutic value in the treatment of certain respiratory disorders, notably in bronchial asthma.


Airway Smooth Muscle Mefenamic Acid Disodium Cromoglycate Prostaglandin Endoperoxide Bronchodilator Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • M. F. Cuthbert
    • 1
    • 2
  • P. J. Gardiner
    • 3
  1. 1.Department of Pharmacology and TherapeuticsLondon Hospital Medical CollegeLondonUK
  2. 2.Chest Unit, Department of MedicineKings College HospitalLondonEngland
  3. 3.Research DepartmentMiles Laboratories LimitedSlough, BerksEngland

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