Regulation of Prostaglanidn F Release from the Uterus During the Estrous Cycle

  • Hans Kindahl
Part of the NATO Advanced Study Institutes Series book series


Already in 1923, Loeb (1) demonstrated that an utero-ovarian relationship existed by performing hysterectomy in guinea pigs and showing that these animals got persistent corpora lutea. Phariss and Wyngarden (2) postulated that the luteolytic substance from the uterus might be prostaglandin F, and McCracken et al. (3) identified release of PGF into the utero-ovarian vein concomitant with regression of corpus luteum in the sheep. Several different types of prostaglandins and thromboxanes can be produced in the uterus (4), however, PGF seems to be the far dominating substance which is released into the venous drainage of the uterus and regulating the life-span of the corpus luteum.


Corpus Luteum Estrous Cycle Progesterone Level Late Luteal Phase Oestrous Cycle 
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  1. 1.
    L. Loeb, The effect of extirpation of the uterus on the life and function of the corpus luteum in the guinea pig, Proc. Soc. Exptl. Biol. Med., 20: 441 (1923).Google Scholar
  2. 2.
    B. B. Phariss and L. J. Wyngarden, The effect of prostaglandin F2α on the progestogen content of ovaries from pseudopregnant rats, Proc. Soc. Exptl. Biol. Med., 130: 92 (1969).Google Scholar
  3. 3.
    J. A. McCracken, J. C. Carlson, M. E. Glew, J. R. Coding, D. T. Baird, K. Green and B. Samuelsson, Prostaglandin F2α identified as a luteolytic hormone in sheep, Nature New Biol., 238: 129 (1972).PubMedCrossRefGoogle Scholar
  4. 4.
    N. L. Poyser, this publication 1980.Google Scholar
  5. 5.
    A. R. Gleeson, G. D. Thorburn and R. I. Cox, Prostaglandin F concentrations in the uteroovarian venous plasma of the sow during the late luteal phase of the oestrous cycle, Prostaglandins, 5: 521 (1974).PubMedGoogle Scholar
  6. 6.
    H. Kindahl, L.-E. Edqvist, A. Bane and E. Granstrom, Blood levels of progesterone and 15-keto-13,14-dihydroprostaglandin F2α during the normal oestrous cycle and early pregnancy in heifers, Acta Endocrinol., 82: 134 (1976).PubMedGoogle Scholar
  7. 7.
    H. Kindahl, L.-E. Edqvist, E. Granstrom and A. Bane, The release of prostaglandin F2α as reflected by 15-keto-13,14- dihydroprostaglandin F2α in the peripheral circulation during normal luteolysis in heifers, Prostaglandins, 11: 871 (1976).PubMedGoogle Scholar
  8. 8.
    J. S. Roberts, B. Barcikowski, L. Wilson, R. C. Skarnes and J. A. McCracken, Hormonal and related factors affecting the release of prostaglandin F2α from the uterus, J. Steroid Biochem., 6: 1091 (1975).PubMedCrossRefGoogle Scholar
  9. 9.
    H.H. Kindahl, E. Granström, L. E. Edqvist and P. Eneroth, Prostaglandin levels in peripheral plasma during the reproductive cycle. In “Advances in Prostaglandin and Thromboxane Research”, vol. 2, B. Samuelsson and R. Paoletti, eds., Raven Press (1976), 667.Google Scholar
  10. 10.
    G. H. Stabenfeldt, L.-E. Edqvist, H. Kindahl, B. Gustafsson and A. Bane, Physiological concepts in female reproduction and their practical implications. J. Amer. Vet. Med. Ass., 172: 667 (1978).PubMedGoogle Scholar
  11. 11.
    M. P. E. Moeljono, W. W. Thatcher, F. W. Bazer, M. Frank, L. J. Owens and C. J. Wilcox, A study of prostaglandin F2α as the luteolysin in swine: II. Characterization and comparison of prostaglandin F, estrogens and progestin concentrations in utero-ovarian vein plasma of non-pregnant and pregnant gilts, Prostaglandins, 14: 543 (1977).PubMedGoogle Scholar
  12. 12.
    V. M. Shille, I. Karlbom, S. Einarsson, K. Larsson, H. Kindahl and L.-E. Edqvist, Concentrations of progesterone and 15-keto13,14-dihydroprostaglandin F2α in peripheral plasma during the estrous cycle and early pregnancy in gilts, Zbl. Vet. Med. A., 26: 169 (1979).Google Scholar
  13. 13.
    D. M. Hallford, R. P. Wetteman, E. J. Turman and I. T. Omtvedt, Luteal function in gilts after prostaglandin F2α, J. Anim. Sci., 41: 1706 (1975).PubMedGoogle Scholar
  14. 14.
    E. Granstrom and H. Kindahl, Radioimmunoassay for urinary metabolites of prostaglandin F2α, Prostaglandins, 12: 759 (1976).PubMedGoogle Scholar
  15. 15.
    F. R. Blatchley, B. T. Donovan, E. W. Horton and N. L. Poyser, The release of prostaglandins and progestin into the utero-ovarian venous blood of guinea-pigs during the estrous cycle and following estrogen treatment, J. Physiol., 223: 69 (1972).PubMedGoogle Scholar
  16. 16.
    P. Wlodawer, H. Kindahl and M. Hamberg, Biosynthesis of prostaglandin F2α from arachidonic acid and prostaglandin endoperoxides in the uterus, Biochim. Biophys. Acta, 431: 603 (1976).PubMedCrossRefGoogle Scholar
  17. 17.
    B. E. Seguin, D. A. Morrow and T. M. Louis, Luteolysis, luteostasis, and the effect of prostaglandin F2α in cows after endometrial irritation, Amer. J. Vet. Res., 35: 57 (1974).Google Scholar
  18. 18.
    H. Kindahl, E. Granstrom, L.-E. Edqvist, B. Gustafsson, G. Astrom and G. Stabenfeldt, Progesterone and 15-keto-13,14dihydroprostaglandin F2α levels in peripheral circulation after intrauterine iodine infusions in cows, Acta Vet. Scand., 18: 274 (1977).PubMedGoogle Scholar
  19. 19.
    D. P. Neely, G. H. Stabenfeldt, H. Kindahl, J. P. Hughes and J. W. Kendrick, Effect of intrauterine saline infusion during the late luteal phase on the estrous cycle and luteal function of the mare, Am. J. Vet. Res., 40: 665 (1979)PubMedGoogle Scholar
  20. 20.
    B. V. Caldwell, S. A. Tilson, W. A. Brock and L. Speroff, The effects of exogenous progesterone and estradiol on prostaglandin F levels in ovariectomized ewes, Prostaglandins, 1: 217 (1972).PubMedGoogle Scholar
  21. 21.
    T. M. Louis, D. M. Parry, J. S. Robinson, G. D. Thorburn and J. R. G. Challis, Effects of exogenous progesterone and oestradiol on prostaglandin F and 13,14-dihydro-l5-oxo prostaglandin F2α concentrations in uteri and plasma of ovariectomized ewes, J. Endocr., 73: 427 (1977).PubMedCrossRefGoogle Scholar
  22. 22.
    J. R. G. Challis, C. S. Forster, B. J. A. Furr, J. S. Robinson and G. D. Thorburn, Production of prostaglandin Fα in ewes following luteal regression induced with a prostaglandin analogue, Estrumate (cloprostenol; I.C.I. 80996), Prostaglandins, 11: 537 (1976).PubMedGoogle Scholar
  23. 23.
    H. Kindahl, L.-E. Edqvist and J.-O. Lindell, On the control of prostaglandin release during the bovine estrous cycle, Abstr. International Prostaglandin Conference, Washington, (1979), 61.Google Scholar
  24. 24.
    H. Kindahl, J.-O. Lindell and L.-E. Edqvist, On the control of prostaglandin release during the bovine estrous cycle. Effects of progesterone implants, Prostaglandins, (1979) in press.Google Scholar
  25. 25.
    J. F. Smith, R. J. Fairclough and A. J. Peterson, Plasma levels of progesterone, Provera, oestradiol-17β, and 13,14-dihydro-l5-keto-prostaglandin F in cows treated with Provera-impregnated intravaginal sponges, J. Reprod. Fert. 55: 359 (1979).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Hans Kindahl
    • 1
  1. 1.Department of Obstetrics and Gynaecology College of Veterinary MedicineSwedish University of Agricultural SciencesUppsalaSweden

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