Regulation of Prostaglanidn F2α Release from the Uterus During the Estrous Cycle
Already in 1923, Loeb (1) demonstrated that an utero-ovarian relationship existed by performing hysterectomy in guinea pigs and showing that these animals got persistent corpora lutea. Phariss and Wyngarden (2) postulated that the luteolytic substance from the uterus might be prostaglandin F2α, and McCracken et al. (3) identified release of PGF2α into the utero-ovarian vein concomitant with regression of corpus luteum in the sheep. Several different types of prostaglandins and thromboxanes can be produced in the uterus (4), however, PGF2α seems to be the far dominating substance which is released into the venous drainage of the uterus and regulating the life-span of the corpus luteum.
KeywordsCorpus Luteum Estrous Cycle Progesterone Level Late Luteal Phase Oestrous Cycle
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