Gonadal Function

  • N. L. Poyser
  • Christine A. Phillips
Part of the NATO Advanced Study Institutes Series book series


The original discovery of “prostaglandin” (PG) in human semen has meant that the role of prostaglandins in reproduction has always received much attention. The actions of PGE and PGF of both the 1- and 2- series on reproductive tissues have been extensively studied. With the development of radioimmunoassays (RIA) for prostaglandins, measurements into the amounts of PGE and PGF synthesised by and released from reproductive tissues in relation to physiological events has been possible, and many significant changes have been observed. The physiological roles of PGE2 and PGF in reproduction were summarised at the first NATO Advanced Study Institute on Prostaglandins (1). With the discovery of the PG endoperoxides, thromboxanes (TX) and prostacyclin (PGI2), it has become unsatisfactory to study only PGE2 and PGF when investigating prostaglandin action on and release from reproductive tissues. However, information regarding the action of PG endoperoxides and TXA2 on reproductive tissues is very limited due, no doubt, to the unstable nature of these compounds with their inherent difficulty in handling especially when one is looking for chronic effects. TXA2 can be measured as its stable metabolite TXB2, by RIA or gas chromatography — mass spectrometry (GC-MS). Thromboxane production by reproductive tissues may, therefore, be measured. Prostacyclin is somewhat more stable so its actions on tissues can be examined. However, the effects of chronic treatment in vivo may be more difficult to investigate, though stable analogues will undoubtedly make this easier. Prostacyclin synthesis by and release from reproductive tissues can be estimated by measuring its metabolite, 6-oxo-PGF by RIA or GC-MS. Consequently, the actions of prostacyclin on reproductive tissues is being examined, and the production of thromboxanes and prostacyclin by these tissues is being investigated. This article will attempt to summarise some of the data which is known. There is little information regarding the male, so the female of the species will be discussed exclusively.


Luteinizing Hormone Amniotic Fluid Corpus Luteum Follicular Fluid Reproductive Tissue 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • N. L. Poyser
    • 1
  • Christine A. Phillips
    • 1
  1. 1.Department of PharmacologyUnversity of EdinburghEdinburghScotland, UK

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