Prostaglandins and the Uterine Circulation
By late pregnancy, uterine blood flow is 30 to 40 times that of the non-pregnant state (1). The great capacity of the uterine vasculature to adapt itself to the enormous increase in the physiological demands imposed by gestation might be caused by either the appearance of new or increased production of pre-existing compounds which influence uterine vascular resistance. The mechanism which regulates blood flow to the pregnant uterus is not well defined; the proposal that it involves uterine prostaglandins is supported by our studies.
KeywordsRenal Blood Flow Late Pregnancy Prostaglandin Synthesis Prostaglandin Endoperoxide Uterine Blood Flow
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