Prostaglandin Analogs that Antagonize the Vascular Responses to Particular Prostaglandins

  • Thomas M. Fitzpatrick
  • Robert B. Stinger
  • Peter W. Ramwell
  • Peter A. Kot
Part of the NATO Advanced Study Institutes Series book series


In the current literature, there are numerous reports of the biological activity of exogenously administered prostaglandins and variations in the endogenous production of prostaglandins under varie physiologic conditions. However, no method has been developed that clearly differentiates the in vivo actions of each biologically active product of arachidonic acid metabolism. Thus, the true physiologic and pathophysiologic significance of these compounds remains somewhat theoretical.


Contractile Response Arachidonic Acid Metabolism Systemic Arterial Pressure Prostaglandin Analog Prostaglandin Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    A. Bennett, Prostaglandin antagonists, p.83, in: “Advances in Drug Research”, N. J. Harper and A. B. Simonds, eds., Academic Press, New York (1974).Google Scholar
  2. 2.
    A. Bennett and J. Posner, Studies on prostaglandin antagonists, Br. J. Pharmacol., 42: 584 (1971).PubMedCrossRefGoogle Scholar
  3. 3.
    B. R. Beitch and K. E. Eakins, The effects of prostaglandins on the intraocular pressure of the rabbit, Br. J. Pharmacol., 37: 158 (1969).PubMedCrossRefGoogle Scholar
  4. 4.
    J. F. Burka and P. Eyre, Studies of prostaglandins and prostaglandin antagonists on bovine pulmonary vein in vitro, Prostaglandins, 6: 333 (1974).PubMedGoogle Scholar
  5. 5.
    N. Chand and P. Eyre, Effects of prostaglandin E1, E2 and F2a and polyphloretin phosphate on carotid blood pressure of domestic fowl, Arch. Int. Pharm. Ther., 221: 261 (1976).Google Scholar
  6. 6.
    W. E. Coyne and J. W. Cusic, Anticonvulsant semicarbazides, J. Med. Chem., 11: 1158 (1968).CrossRefGoogle Scholar
  7. 7.
    W. W. Douglas, Histamine and antihistamines; 5-hydroxytryptamine and antagonists, p.621, in: “The Pharmacological Basis of Therapeutics”, L. S. Goodman and A. Gilman, eds., The Macmillan Company, New York (1970).Google Scholar
  8. 8.
    K. E. Eakins and J. H. Sanner, Prostaglandin antagonists, p.261„ in: “The Prostaglandins, Progress in Research”, S. M. M. Karim, ed., Medical and Technical Pub. Co. Ltd., London (1972).Google Scholar
  9. 9.
    J. D. Flack, Biological significance of the prostaglandins, p.174, in: “Recent Progress in Hormone Research”, P. W. Ramwell and J. E. Shaw, eds., Academic Press, New York (1970).Google Scholar
  10. 10.
    J. Fried, S. Heim, S. J. Etheredge, P. Sunder-Plassman, T. S. Santhanakrishan and J. Himizu, Synthesis of 15desoxy-7-oxaprostaglandin Fla and related substances, in: “Prostaglandin Symposium of the Worcester Foundation for Experimental Biology”, P. W. Ramwell and J. E. Shaw, eds., John Wiley and Sons, New York (1968).Google Scholar
  11. 11.
    J. Fried, T. S. Santhanakrishnan, J. Himizu, C. H. Lin, S. H. Ford, B. Rubin and E. 0. Grigas, Prostaglandin antagonists: synthesis and smooth muscle activity, Nature, 223: 208 (1969).PubMedCrossRefGoogle Scholar
  12. 12.
    S. Hynie, J. Cepelik, M. Cernohorsky, V. Klenerova, J. Skrivanova and M. Wenke, 7-oxa-13 prostanoic acid and polyphloretin phosphate as non-specific antagonist of the stimulatory effects of different agents on adenylate cyclase from various tissues, Prostaglandins, 10: 971 (1975).PubMedGoogle Scholar
  13. 13.
    F. A. Keuhl and J. L. Humes, Direct evidence for a prostaglandin receptor and its application to prostaglandin measurement, Proc. Nat. Acad. Sci. U.S.A., 69: 480 (1972).CrossRefGoogle Scholar
  14. 14.
    Y. T. Maddox, P. W. Ramwell, C. S. Shiner and E. J. Corey, Amide and 1-amino derivatives of F prostaglandins as prostaglandin antagonists, Nature, 273: 549 (1978).PubMedCrossRefGoogle Scholar
  15. 15.
    A. A. Mathe, K. Strandberg and B. Fredholm, Antagonism of prostaglandin F2a induced bronchoconstriction and blood pressure changes by polyphloretin phosphate in the guinea pig and cat, J. Pharm. Pharmac., 24: 378 (1972).CrossRefGoogle Scholar
  16. 16.
    J. Nakano, Relationship between the chemical structure of prostaglandins and their vasoactivities in dogs, Br. J. Pharmacol., 44: 63 (1972).PubMedCrossRefGoogle Scholar
  17. 17.
    J. Nakano,-A. V. Prancan and S. Moore, Effect of the prostaglandin antagonists in the vasoactivities of prostaglandin El (PGE1), E2 (PGE2), Al (PGA]) and F2a (PGF2a), Clin. Res., 19: 712 (1971).Google Scholar
  18. 18.
    M. Nickerson, Drugs inhibiting adrenergic nerves and structures innervated by them, p.549, in: “The Pharmacological Basis of Therapeutics”, L. S. Goodman and A. Gilman, eds., The Macmillan Company, New York (1970).Google Scholar
  19. 19.
    N. Ozaki, J. D. Kohli, L. I. Goldberg and J. Fried, Vascular smooth vuscle activity of 7-oxa-13-prostanoic acid, Blood Vessels, 16: 52 (1979).PubMedGoogle Scholar
  20. 20.
    M. K. Park and D. C. Dyer, Effect of polyphloretin phosphate and 7-oxa-13-prostanoic acid on vasoactive actions of prostaglandin E2 and 5-hydroxytryptamine on isolated human umbilical arteries and 7-oxa-13-prostanoic acid on vasoactive actions of prostaglandin E2 and 5-hydroxytryptamine on isolated human umbilical arteries, Prostaglandins, 3: 913 (1973).PubMedGoogle Scholar
  21. 21.
    J. H. Sanner, Antagonism of prostaglandin E2 by 1-acetyl-2(8-chloro-10,11-dihydrodibenz b,f 1,4 oxazepine-l0-carbonyl) hydrazine (SC-19220), Arch. Int. Pharmacodyn, Ther., 180:46(1969).Google Scholar
  22. 22.
    J. Sauner, Prostaglandin inhibition with a dibenzoxazepine hydrazide derivative and morphine, Ann. N.Y. Acad. Sci., 180: 396 (1971).CrossRefGoogle Scholar
  23. 23.
    J. Sauner and K. E. Eakins, Prostaglandin antagonists, p.139, in: “Prostaglandins: Chemical and Biological Abnts S. M. M. Karim, ed., University Park Press, Baltimore (1976).Google Scholar
  24. 24.
    E. L. Tolman, R. Partridge and E. T. Barris, Prostaglandin E antagonists activity of 11,15-bisdeoxy prostaglandin El and congeners, Prostaglandins, 14: 11 (1977).PubMedGoogle Scholar
  25. 25.
    R. Villanueva, L. Hinds, R. L. Katz and K. E. Eakins, The effect of polyphloretin phosphate on some smooth muscle actions of prostaglandins in the cat, J. Pharm. and Exp. Ther., 180: 78 (1972).Google Scholar
  26. 26.
    T. C. Wicks, J. C. Rose, M. Johnson, P. W.Ramwell and P. A. Kot, Vascular responses to arachidonic acid in the perfused canine lung, Cir. Res., 38:167 (1976).Google Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Thomas M. Fitzpatrick
    • 1
  • Robert B. Stinger
    • 1
  • Peter W. Ramwell
    • 1
  • Peter A. Kot
    • 1
  1. 1.Department of Physiology and BiophysicsGeorgetown University Medical CenterUSA

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