Prostaglandin Mechanisms in Blood Pressure Regulation and Hypertension

  • John C. McGiff
  • Eric G. Spokas
  • Patrick Y-K Wong
Part of the NATO Advanced Study Institutes Series book series


In 1970, three studies were published which provided the basis for the proposal that prostaglandins are modulators of pressor hormones and adrenergic nervous activity (1,2,3). In the first two studies, infusion of either angiotensin II or norepinephrine was shown to cause release of PGE-like material into renal venous blood; the latter was associated with attenuation of the vasoconstrictor and anti-diuretic actions of these pressor hormones (1,2). In the third study, it was demonstrated that within minutes after induction of unilateral renal ischemia, prostaglandins were released into the venous blood of both kidneys. Release from the contralateral kidney was mediated by angiotensin II, which, presumably, also contributed to the release from the ischemic kidney (3). This study offered an explanation for the antihypertensive function of the contralateral kidney in terms of a possible prostaglandin mechanism. Thus, activation of the reninangiotensin system by renal ischemia can effect enhanced prostaglandin production in the ischemic and contralateral kidneys. A related study on the effects of norepinephrine infusion and renal nerve stimulation on renal function (4) strongly supported the proposal that renal prostaglandins act as a component of an intrarenal negative feedback control system which moderates anti-diuretic and vasoconstrictor systems.


Renal Blood Flow Prostaglandin Synthesis Blood Pressure Regulation Contralateral Kidney Renal Vascular Resistance 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • John C. McGiff
    • 1
  • Eric G. Spokas
    • 1
  • Patrick Y-K Wong
    • 1
  1. 1.Departments of Pharmacology and MedicineNew York Medical CollegeValhallaUSA

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