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Prostacyclin as an Anti-Atherosclerotic Hormone — A Hypothesis

  • Ryszard J. Gryglewski
Part of the NATO Advanced Study Institutes Series book series

Abstract

Although many factors in pathogenesis of atherosclerosis still remain unknown, intravascular activation of blood platelets seems to play an important role in the development of this disease. The thrombogenic hypothesis of atherosclerosis (the so called “incrustation theory”) was proposed as early as in 1842 by Carl von Rokitansky (1), but Virchow’s “infiltration theory” prevailed and dominated the academic community for many years, owing greatly to Anichkov’s experimental demonstration (2) that atherosclerosis in rabbits could be induced by a diet high in lipids and cholesterol content. The yellow streaks of lipids which “infiltrated” the rabbit aorta could be seen with the naked eye.

Keywords

Platelet Aggregation Arterial Wall Atheromatic Plaque Atherogenic Diet Rabbit Aorta 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Ryszard J. Gryglewski
    • 1
  1. 1.Department of PharmacologyCopernicus Academy of MedicineCracowPoland

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