• S. Moncada
  • J. R. Vane
Part of the NATO Advanced Study Institutes Series book series


In 1976, the Wellcome group discovered that prostaglandin endoperoxides were transformed by a microsomal enzyme from blood vessels into an unstable substance which is a potent vasodilator and an inhibitor of platelet aggregation (13,14, 75,76, 42). This compound originally called PGX was later chemically identified as an intermediate in the formation of 6-oxo-PGF, a compound described earlier (95). PGX was then renamed prostacyclin and given the abbreviation of PGI2 (61).


Arachidonic Acid Platelet Aggregation Thrombus Formation Bleeding Time Renin Release 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • S. Moncada
    • 1
  • J. R. Vane
    • 1
  1. 1.Wellcome Research LaboratoriesLangley CourtBeckenham, KentUK

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