Prostaglandins and Inflammatory Hyperalgesia

  • S. H. Ferreira
Part of the NATO Advanced Study Institutes Series book series


In our “Discussion on the mode of action of anti-inflammatory drugs” (in this book) it is pointed out that the therapeutic effects of aspirin-like drugs are symptomatic. These drugs do not interfere with the evolution of the chronic processes but act on the expression of some inflammatory signs and symptoms. Possibly, most of the therapeutic use of aspirin-like drugs in many diseases is due to their antialgic effect rather than to their anti-oedematogenic properties. If one day, we have drugs which really interfere with the progression of chronic diseases, aspirin-like drugs, i.e. cyclo-oxygenase inhibitors, will be classified as pseudo-anti-inflammatory drugs.


Analgesic Effect Opioid Antagonist Intraplantar Injection Prostaglandin Synthetase Inflammatory Hyperalgesia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    V. A. Alabaster and Y. S. Bakhle. Release of smooth muscle-contracting substances from isolated perfused lungs. Europ. J. Pharmac., 35: 349–360 (1976).CrossRefGoogle Scholar
  2. 2.
    C. R. Beddell, R. L. Follenfant, L. A. Lowe, F. B. Ubatuba, S. Wilkinson and R. J. Miller. Analogues of the enkephalins -Structural requirements for opioid activity. In: “Biological Activity and Chemical Structure”. J. A. Keverling Buisman, ed., Elvesier Scientific Publishing Company, New York, pp. 177–193 (1977).Google Scholar
  3. 3.
    W. C. Chang, S. Murota and S. Tsurufugi. A new prostaglandin transformed from arachidonic acid in carrageenin-induced granuloma. Biochem. Biophys. Res. Comm., 72: 1259–1264 (1976).PubMedCrossRefGoogle Scholar
  4. 4.
    M. L. Cohn, M. Cohn and F. H. Taylor. Guanosine 3’, 5’ monophosphate: A central nervous system regulator of analgesia. Science, 199: 319–322 (1978).PubMedCrossRefGoogle Scholar
  5. 5.
    H. O. Collier and A. C. Roy. Inhibition of E- rostaglandins sensitive adenyl cyclase as the mechanism of morphine analgesia. Prostaglandins, 7: 361–376 (1974).PubMedGoogle Scholar
  6. 6.
    A. Dembiska-Kiec, A. Zmuda and J. Krupinska. Inhibition of prostaglandin synthetase by aspirin-like drugs in different microsomal preparations. In: “Advances in Prostaglandins and Thromboxane Research”, vol. 1. B. Samuelsson and R. Paoletti, eds., Raven Press, New York, pp. 99–103 (1976).Google Scholar
  7. 7.
    J. C. Eccles and P. L. Mcgeer. Ionotropic and metabotropic transmission. Trends in Neurosciences, 2: 39–40 (1979).CrossRefGoogle Scholar
  8. 8.
    J. Faires and D. J. McCarty. Acute arthritis in man and dog after intrasynovial injection of sodium urate crystals. Lancet, 11: 682–685 (1962).CrossRefGoogle Scholar
  9. 9.
    S. Ferri, A. Santagostino, P. C. Braga and I. Galatelas. Decrease antinociceptive effect of morphine in rats treated intraventricularly with prostaglandin El. Psychopharmacologia (Berl.), 39: 231–235 (1974).CrossRefGoogle Scholar
  10. 10.
    S. H. Ferreira. Prostaglandins, aspirin-like drugs and analgesia. Nature, New Biol., 240: 200–203 (1972).CrossRefGoogle Scholar
  11. 11.
    S. H. Ferreira and M. Nakamura. Prostaglandin hiperalgesia: I, A cAMP/Ca2 dependent process; II, The peripheral analgesic activity of morphine, enkephalins and opioid antagonists; III, Relevance of the peripheral effect for the analgesic action of opioid antagonists. Prostaglandins, in press (1979).Google Scholar
  12. 12.
    S. H. Ferreira and J. R. Vane. Mode of action of anti-inflammatory agents which are prostaglandin synthetase inhibitors. In: “Anti-Inflammatory Drugs”, J. R. Vane and S. H. Ferreira, eds., Handbook of Experimental Pharmacology, vol. 50/II - Springer Verlag, Berlin, Heidelberg, pp. 348–398 (1978).Google Scholar
  13. 13.
    S. H. Ferriera, B. B. Lorenzetti and F. M. A. Correa. Central and peripheral antialgesic action of aspirin-like drugs. European J. Pharmacol., 53: 39–48 (1978).CrossRefGoogle Scholar
  14. 14.
    S. H. Ferreira, S. Moncada and J. R. Vane. Some effects of inhibiting endogenous prostaglandin formation on the responses of the cat spleen. Br. J. Pharmac., 47: 48–58 (1973).CrossRefGoogle Scholar
  15. 15.
    S. H. Ferreira, S. Moncada and J.R. Vane. Prostaglandins and the mechanism of analgesia produced by aspirin-like drugs. Br. J. Pharmac., 49: 86–97 (1973).CrossRefGoogle Scholar
  16. 16.
    S. H. Ferreira, M. Nakamura and M. S. A. Castro. The hyperalgesic effects of prostacyclin and prostaglandin E2. Prostaglandins, 16: 31–37 (1978).PubMedGoogle Scholar
  17. 17.
    R. J. Flower and J. R. Vane. Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetamido - phenol). Nature, 240: 410–411 (1972).PubMedCrossRefGoogle Scholar
  18. 18.
    N. D. Goldberg, M. K. Haddox, S. E. Nicol, D. B. Glass, C. H. Sanford, F. A. Kuehl Jr. and R. Estensen. Biologic regulation through opposing influences of cyclic GMP and cyclic AMP: The yin yang hypothesis. In: “Advances in Cyclic Nucleotides Research”, G. I. Drummond, P. Greengard and G. A. Robinson, eds. Raven Press, New York, vol. 5 pp. 307–330 (1975).Google Scholar
  19. 19.
    A. G. Herman and S. Moncada. Release of prostaglandins and incapacitation after injection of endotoxin in the knee joint of the dog. Br. J. Pharmac., 53: 465p (1975).Google Scholar
  20. 20.
    H. Juan and F. Lembeck. Action of peptides and other algesic agents on paravascular pain receptors on the isolated perfused rabbit ear. Naunym-Schmiedeberg`s Arch. Pharmac., 283: 151–164 (1974).Google Scholar
  21. 21.
    H. Juan and F. Lembeck. Inhibition of action of Eprostaglandins (PGs) on paravascular pain receptors. Naunym-Schmiedebergs Arch. Pharmac., 285: R36 (1974).Google Scholar
  22. 22.
    J. Knoll, S. Furst and S. Makleits. The pharmacology of N-substituted azido-morphines. Arch. Ínt. Pharmacodyn., 228: 268–292 (1977).PubMedGoogle Scholar
  23. 23.
    L. Lasagna. The clinical pharmacology of analgesics and analgesic antagonists. In: “Proc. of the 3rd International Pharmacol. Meeting”, R. K. S. Lim, ed. Pergamon Press,Oxford, vol. 9: 113–120 (1968).Google Scholar
  24. 24.
    R. K. S. Lim, F. Guzman, D. W. Rodgers, K. Goto, G. Braun, G. D. Dickerson and R. J. Engle. Site of action of narcotic and non-narcotic analgesics determined by blocking bradykinin-evoked visceral pain. Arch. Int. Pharmacodyn., 152: 25–59 (1964).PubMedGoogle Scholar
  25. 25.
    W. R. Martin. Opioids antagonists. Pharmacol. Reviews, 4: 463–521 (1967).Google Scholar
  26. 26.
    S. Moncada, S. H. Ferreira and J. R. Vane. Inhibition of prostaglandin biosynthesis as the mechanism of analgesia of aspirin-like drugs in the dog knee joint. Europ. J. Pharmacol., 31: 250–260 (1975).CrossRefGoogle Scholar
  27. 27.
    E. R. Perl. Sensitization of nociceptors and its relation to sensation. In: “Advances in Pain Research and Therapy”, J. J. Bonica and D. Albe-Fessard, eds., Raven Press, New York, vol. I, pp. 17–34 (1976).Google Scholar
  28. 28.
    L. 0. Randall and J. J. Selitto. A method for measurement of analgesic activity on inflammed tissue. Arch. Int. Pharmacodyn., 111: 409–419 (1957).Google Scholar
  29. 29.
    M. E. Rosenthale, A. Dervinis, J. Kassarich and S. Singer. Prostaglandins and anti-inflammatory drugs in the dog knee joint. J. Pharm.Pharmac., 24: 149–152 (1972).CrossRefGoogle Scholar
  30. 30.
    E. W. Sutherland, G. A. Robison and R. W. Butcher. Some aspects of the biological role of adenosine 3’, 5’monophosphate (Cyclic AMP). Circulation, 37: 279–306 (1968).CrossRefGoogle Scholar
  31. 31.
    J. W. Ward, M. Foxwell and W. H. Funderburk. The detection of analgesia produced by morphine antagonists in laboratory animals. Pharmacologist, 7: 163 (1965).Google Scholar
  32. 32.
    A. L. Willis and M. Cornelsen. Repeated injection of prostaglandin E2 in rat paw induced chronic swelling and marked decrease in pain threshold. Prostaglandins, 3: 353–357 (1973).PubMedGoogle Scholar
  33. 33.
    C. A. Winter and L. Flataker. Reaction thresholds to pressure in edematous hindpaws of rats and responses to analgesic drugs. J. Pharmacol. Exp. Therapeutics, 150: 165–171 (1965).Google Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • S. H. Ferreira
    • 1
  1. 1.Department of Pharmacology, Faculty of Medicine of Ribeirão PretoUniversity of São PauloRibeirão PretoBrazil

Personalised recommendations