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The Neurochemical Control of Mating Behavior

  • William R. Crowley
  • Frank P. Zemlan

Abstract

This chapter provides a survey of psychopharmacological studies of male and female sexual behavior, primarily conducted on rodent species. Because the expression of these behaviors normally requires the presence of gonadal hormones, this chapter attempts to integrate behavioral studies with studies on the effects of these hormones on neurotransmitter metabolism. The bulk of the literature in these fields focuses on norepinephrine (NE), dopamine (DA), serotonin (5-HT) and acetylcholine (ACh), all of which are involved in neuroendocrine regulation and in a variety of behaviors other than mating. For this reason, we also have attempted to place the neuropharmacology of reproductive behavior within a broader context. The other chapters in Part IV of this volume present closely related material.

Keywords

Sexual Behavior Mating Behavior Copulatory Behavior Male Sexual Behavior Female Sexual Behavior 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ahlenius, S., Eriksson, H., Larsson, K., Modigh, K., and Södersten, P., 1971, Mating behavior in the male rat treated with p-chlorophenylalanine methyl ester alone and in combination with pargyline, Psychopharmacologia 20:383.PubMedGoogle Scholar
  2. Ahlenius, S., Eriksson, H., and Södersten, P., 1972, Effects of tetrabenazine on lordosis behavior and on brain monoamines in the female rat,J. Neural Trans. 33:155.Google Scholar
  3. Ahren, K., Fuxe, K. Hamberger, L., and Hökfelt, T., 1971, Turnover changes in the tuberoinfundibular dopamine neurons during the ovarian cycle of the rat, Endocrinology 88:1415.PubMedGoogle Scholar
  4. Andén, N.-E., Larsson, K., and Steg, G., 1971, The influence of the nigroneostriatal dopamine pathway on spinal motorneuron activity, Acta Physiol. Scand. 82:268.PubMedGoogle Scholar
  5. Antelman, S. M., and Caggiula, A. R., 1977, Norepinephrine-dopamine interactions and behavior, Science 195:646.PubMedGoogle Scholar
  6. Antelman, S. M., Szechtman, H., Chin, P., and Fisher, A. E., 1975. Tail pinch induced eating, gnawing, and licking behavior in rats: Dependence on the nigrostriatal dopamine system, Brain Res. 99:319.PubMedGoogle Scholar
  7. Barbeau, A., 1969, L-DOPA therapy in Parkinson’s disease, a critical review of nine years’ experience, Can. Med. Assoc. J. 101:791.Google Scholar
  8. Beach, F. A., 1942, Importance of progesterone to induction of sexual receptivity in spayed female rats, Proc. Soc. Exp. Biol. Med. 51:369.Google Scholar
  9. Beach, F. A., 1976, Sexual attractivity, proceptivity, and receptivity in female mammals, Horm. Behav. 7:105.PubMedGoogle Scholar
  10. Beattie, C. W., Rodgers, C. H., and Soyka, L. F., 1972, Influence of ovariectomy and ovarian steroids on hypothalamic tyrosine hydroxylase activity in the rat, Endocrinology 91:276.PubMedGoogle Scholar
  11. Bedard, P., Sanokova, J., Boucher, R., and Langelier, P., 1979, Effect of estrogens on apomorphine-induced circling behavior in the rat, Can. J. Physiol. Pharmacol. 56:538.Google Scholar
  12. Belt, B. G., 1973, Some organic causes of impotence, Med. Asp. Hum. Sex. 7:152.Google Scholar
  13. Benkert, O., 1973, Pharmacological experiments to stimulate human sexual behavior, in: Psychophannacology, Sexual Disorders, and Drug Abuse (T. A. Ban, J. R. Boissier, G.J. Gessa, H. Heimann, L. Hoïlister, H. E. Lehmann, I. Munkvad, H. Steinberg, F. Sulser, A. Sundwall, and O. Vinar, eds.), pp. 489–495, North-Holland, Amsterdam.Google Scholar
  14. Benkert, O., and Eversmann, T., 1971, Importance of the anti-serotonin effect for mounting behavior in rats, Experientia 28:532.Google Scholar
  15. Benkert, O., Crombach, G., and Kockott, G., 1972, Effect of L-DOPA on sexually impotent patients, Psychopharmacologia 23:91.PubMedGoogle Scholar
  16. Bertolini, A., 1971a, Behavioural effects of ovine β-LPH intraliquorally injected in the male rabbit, Riv. Farm. Terap. 2:XLIII.Google Scholar
  17. Bertolini, A., 1971b, Different type of sexual excitement produced in rats by intraliquoral ACTH and by intraperitoneal p-chlorophenylalanine, Riv. Farm. Terap. 2:LXXIII.Google Scholar
  18. Bertolini, A., Gentile, G., Greggia, A., Sternieri, F., and Ferrari, W., 1971, Possible role of hypothalamic corticotropin releasing factor in the induction of sexual excitation in adult male rats, Riv. Farm. Terap. 2:243.Google Scholar
  19. Bertolini, A., Gessa, G. L., and Ferrari, W., 1975, Penile erection and ejaculation: A central effect of ACTH-like peptides in mammals, in: Sexual BehaviorPharmacology and Biochemistry (M. Sandler and G. L. Gessa, eds.), pp. 247–257, Raven Press, New York.Google Scholar
  20. Bolme, P., Fuxe, K., and Lidbrink, P., 1972, On the function of central catecholamine neurons— Their role in cardiovascular and arousal mechanisms, Res. Commun. Chem. Pathol. Pharmacol. 4:657.PubMedGoogle Scholar
  21. Bowers, M. B., van Woert, M., and Davis, L., 1971, Sexual behavior during L-DOPA treatment for parkinsonism, Am. J. Psychiatry 127:1691.PubMedGoogle Scholar
  22. Breisch, S. T., Zemlan, F. P., and Hoebel, B. G., 1976, Hyperphagia and obesity following serotonin depletion by intraventricular p-chlorophenylalanine, Science 192:382.PubMedGoogle Scholar
  23. Buller, R. E., and O’Malley, B. W., 1976, The biology and mechanism of steroid hormone receptor interaction with the eukaryotic nucleus, Biochem. Pharmacol. 25:1.PubMedGoogle Scholar
  24. Caggiula, A. R., Shaw, D. H., Antelman, S. M., and Edwards, D. J., 1976, Interactive effects of brain catecholamines and variations in sexual and nonsexual arousal on copulatory behavior of male rats, Brain Res. 111:321.PubMedGoogle Scholar
  25. Caggiula, A., Herndon, J., Antelman, S., Sharp, D., Scanlon, R., Greenstone, D., and Bradshaw, W., 1977, Brain catecholamines and copulatory behavior of male and female rats, Abstracts, East. Reg. Conf. Reprod. Behav., p. 29.Google Scholar
  26. Carlton, P. L., 1963, Cholinergic mechanisms in the control of behavior by the brain, Psychol. Rev. 70:19.PubMedGoogle Scholar
  27. Carter, C. S., 1977, Pharmacological manipulations and sexual behavior in the hamster, Abstracts: East. Reg. Conf. Reprod. Behav. p. 3.Google Scholar
  28. Carter, C. S., and Davis, J. M., 1976, Effects of drugs on sexual arousal and performance, in: Clinical Management of Sexual Disorders (J. Myer, ed.), pp. 195–205, Williams & Wilkins, Baltimore.Google Scholar
  29. Carter, C. S., and Schein, M. W., 1971, Sexual receptivity and exhaustion in the female golden hamster, Horm. Behav. 2:191.Google Scholar
  30. Chew, L. S., and Rinaud, G. A., 1974, Estrogenic regulation of uterine cyclic AMP metabolism, Biochem. Biophys. Acta 362:493.PubMedGoogle Scholar
  31. Clark, T. K., Caggiula, A. R., McConnell, R. A., and Antelman, S. M., 1975, Sexual inhibition is reduced by rostral midbrain lesions in the male rat, Science 190:169.PubMedGoogle Scholar
  32. Coppola, J. A., 1969, Turnover of hypothalamic catecholamines during various states of gonadotropin secretion, Neuro endocrinology 5:75.Google Scholar
  33. Crowley, W. R., Ward, I. L., and Margules, D. L., 1975, Female lordotic behavior mediated by monoamines in male rats,J. Comp. Physiol. Psychol. 88:62.PubMedGoogle Scholar
  34. Crowley, W. R., Feder, H. H., and Morin, L. P., 1976, Role of monoamines in sexual behavior of the female guinea pig, Pharmacol. Biochem. Behav. 4:67.PubMedGoogle Scholar
  35. Crowley, W. R., Nock, B. L., and Feder, H. H., 1978a, Facilitation of lordosis behavior by Clonidine in female guinea pigs, Pharmacol. Biochem. Behav. 8:207.PubMedGoogle Scholar
  36. Crowley, W. R., O’Donohue, T. L., Wachslicht, H., and Jacobowitz, D. M., 1978b, Effects of estrogen and progesterone on plasma gonadotropins and on catecholamine levels and turnover in discrete brain regions of ovariectomized rats, Brain Res. 154:345.PubMedGoogle Scholar
  37. Da Prada, M., Carruba, M., O’Brien, R. A., Saner, A., and Pletscher, A., 1972, The effect of 5,6-dihydroxytryptamine on sexual behavior of male rats, Eur. J. Pharmacol. 19:288.PubMedGoogle Scholar
  38. Davis, G. A., and English, E., 1977, Monoamines and lordosis in the female guinea pig, Horm. Behav. 8:88.PubMedGoogle Scholar
  39. Davis, G. A., and Kohl, R., 1977, The influence of α-receptors on lordosis in the female rat, Pharmacol. Biochem. Behav. 6:47.PubMedGoogle Scholar
  40. Dewsbury, D. A., 1971, Copulatory behavior of male rats following reserpine administration, Psychon. Sci. 22:177.Google Scholar
  41. Dewsbury, D. A., 1972, Effects of tetrabenazine on the copulatory behavior of male rats, Eur. J. Pharmacol. 17:221.PubMedGoogle Scholar
  42. Dewsbury, D. A., 1975, The normal heterosexual pattern of copulatory behavior in the male rats: Effects of drugs that alter brain monoamine levels, in: Sexual BehaviorPharmacology and Biochemistry (M. Sandler and G. L. Gessa, eds.), pp. 169–179, Raven Press, New York.Google Scholar
  43. Dewsbury, D. A., and Davis, H. N., 1970, Effects of reserpine on the copulatory behavior of male rats, Physiol. Behav. 5:1331.PubMedGoogle Scholar
  44. Dewsbury, D. A., Davis, H. N., and Jansen, P. E., 1972, Effects of monoamine oxidase inhibitors on the copulatory behavior of male rats, Psychopharmacologia 24:209.Google Scholar
  45. Donoso, A. O., and de Gutierrez Moyano, M. B., 1970, Adrenergic activity in the hypothalamus and ovulation, Proc. Soc. Exp. Biol. Med. 135:633.PubMedGoogle Scholar
  46. Donoso, A. O., and Stefano, F. J. E., 1967, Sex hormones and concentration of noradrenaline and dopamine in the anterior hypothalamus, Am. J. Physiol. 212:737.PubMedGoogle Scholar
  47. Donoso, A. O., de Gutierrez Moyano, M. B., and Santolaya, R. C., 1969, Metabolism of noradrenaline in the hypothalamus of castrated rats, Neuroendocrinology 4:12.PubMedGoogle Scholar
  48. Eichelman, B. S., and Thoa, N. B., 1973, The aggressive monoamines, Biol. Psychiatry 6:143.PubMedGoogle Scholar
  49. Eliasson, M., 1976, Actions of repeated injections of LSD and apomorphine on the copulatory response of female rats, Pharmacol. Biochem. Behav. 5:621.PubMedGoogle Scholar
  50. Eliasson, M., and Meyerson, B. J., 1977, The effects of lysergic acid diethylamide on copulatory behaviour in the female rat, Neuropharmacology 16:37.PubMedGoogle Scholar
  51. Eliasson, M., Michanek, A., and Meyerson, B. J., 1972, A differential inhibitory action of LSD and amphetamine on copulatory behavior in the female rat, Acta Pharmacol. Toxicol. 31 (Suppl. 1):22.Google Scholar
  52. Espino, C., Sano, M., and Wade, G. M., 1975, Alpha-methyltryptamine blocks facilitation of lordosis by progesterone in spayed, estrogen-primed rats, Pharmacol. Biochem. Behav. 3:557.PubMedGoogle Scholar
  53. Everitt, B. J., and Fuxe, K., 1977a, Dopamine and sexual behaviour in female rats. Effects of dopamine receptor agonists and sulpiride, Neurosci. Lett. 4:209.PubMedGoogle Scholar
  54. Everitt, B. J., and Fuxe, K., 1977b, Serotonin and sexual behaviour in female rats. Effects of hallucinogenic indolealkylamines and phenylethylamines, Neurosci. Lett. 4:215.PubMedGoogle Scholar
  55. Everitt, B. J., Fuxe, K., and Hökfelt, T., 1974, Inhibitory role of dopamine and 5-hydroxytryptamine in the sexual behavior of female rats, Eur. J. Pharmacol. 29:187.PubMedGoogle Scholar
  56. Everitt, B. J., Fuxe, K., Hökfelt, T., and Jonsson, G., 1975a, Role of monoamines in the control by hormones of sexual receptivity in the female rat,J. Comp. Physiol. Psychol. 89:556.PubMedGoogle Scholar
  57. Everitt, B. J., Fuxe, K., and Jonsson, G., 1975b, The effects of 5,7-dihydroxytryptamine lesions of ascending 5-hydroxytryptamine pathways on the sexual and aggressive behavior of female rats,J. Pharmacol. (Paris) 6:25.Google Scholar
  58. Feder, H. H., and Ruf, K. B., 1969, Stimulation of progesterone release and estrous behavior by ACTH in ovariectomized rodents, Endocrinology 84:171.PubMedGoogle Scholar
  59. Ferguson, J., Henriksen, S., Cohen, H., Mitchell, G., Barchas, J., and Dement, W., 1970, Hypersexuality and behavioral changes in cats caused by the administration of p-chlorophenylalanine, Science 168:499.PubMedGoogle Scholar
  60. Foreman, M. M., and Moss, R. L., 1977, Effects of subcutaneous injection and intrahypothalamic infusion of releasing hormones upon lordotic response to repetitive coital stimulation, Horm. Behav. 8:219.PubMedGoogle Scholar
  61. Foreman, M. M., and Moss, R. L., 1978a. Role of hypothalamic alpha and beta adrenergic receptors in the control of lordotic behavior in the ovariectomized-estrogen-primed rat, Pharmacol. Biochem. Behav. 9:235.PubMedGoogle Scholar
  62. Foreman, M. M., and Moss, R. L., 1978b, Role of hypothalamic serotonergic receptors in the control of lordosis behavior in the female rat. Horm. Behav. 10:97.PubMedGoogle Scholar
  63. Franck, J. A., and Ward, I. L., 1975, Amygdaloid mediation of female sexual behavior, Paper presented at the 46th Meeting of the Eastern Psychological Association, New York, April, 1975.Google Scholar
  64. Fuxe, K., 1965, Evidence for the existence of monoamine-containing neurons in the central nervous system. IV. The distribution of monoamine nerve terminals in the central nervous system, Acta Physiol. Scand. (Suppl.) 247:36.Google Scholar
  65. Fuxe, K., and Hökfelt, T., 1970, Central monoaminergic systems and hypothalamic function, in: The Hypothalamus (L. Martini, M. Motta, and F. Fraschini, eds.), pp. 123–138, Academic Press, New York.Google Scholar
  66. Fuxe, K., Hökfelt, T., and Nilsson, O., 1967, Activity changes in the tuberoinfundibular dopamine neurons of the rat during various states of the reproductive cycle, Life Sci. 6:2057.PubMedGoogle Scholar
  67. Fuxe, K., Hökfelt, T., and Nilsson, O., 1969, Castration, sex hormones and tuberoinfundibular dopamine neurons, Neuroendocrinology 5:107.PubMedGoogle Scholar
  68. Fuxe, K., Everitt, B. J., and Hökfelt, T., 1977a, Enhancement of sexual behavior in the female rat by nicotine, Pharmacol. Biochem. Behav. 7:147.PubMedGoogle Scholar
  69. Fuxe, K., Löfström, A., Eneroth, P., Gustaffson, J.-A., Skett, P., Hôkfelt, T., Wiesel, F.-A., and Agnati, L., 1977b, Involvement of central catecholamines in the feedback actions of 17β-estradiolbenzoate on luteinizing hormone secretion in the ovariectomized female rat, Psychoneuroendocrinology 2:203.PubMedGoogle Scholar
  70. Fuxe, K., Andersson, K., Agnati, L. F., Ferland, L., Hökfelt, T., Eneroth, P., Gustaffson, J.-A., and Skett, P., 1979, Central catecholamine systems and neuroendocrine regulation. Controllers of anterior pituitory secretion, in: Catecholamines: Basic and Clinical Frontiers (E. Usdin, I.J. Kopin, and J. Barchas, eds.), pp. 1187–1203, Pergamon Press, New York.Google Scholar
  71. Gawienowski, A. M., and Hodgen, D. M., 1971, Homosexual activity in male rats after p-chlorophenylalanine: Effects of hypophysectomy and testosterone, Physiol. Behav. 7:551.PubMedGoogle Scholar
  72. Gawienowski, A. M., Merker, J. W., and Damon, R. A., 1973, Alteration of sex accessory glands by p-chlorophenylalanine and testosterone, Life Sci. 12:307.Google Scholar
  73. Gerall, A. A., and Kenney, A., 1970, Neonatally androgenized female’s responsiveness to estrogen and progesterone, Endocrinology 87:560.PubMedGoogle Scholar
  74. Gessa, G. L., and Tagliamonte, A., 1973, Role of brain monoamines in controlling sexual behavior in male animals, in: Psychopharmacology, Sexual Disorders and Drug Abuse (T. A. Ban, J. R. Boissier, G.J. Gessa, H. Heimann, L. Hollister, H. E. Lehmann, I. Munkvad, H. Steinberg. F. Sulser, A. Sundwall, and O. Vinar, eds.), pp. 451–462, North-Holland, Amsterdam.Google Scholar
  75. Gessa, G. L., and Tagliamonte, A., 1975, Role of brain serotonin and dopamine in male sexual behavior, in: Sexual BehaviorPharmacology and Biochemistry (M. Sandler and G. L. Gessa, eds.), pp. 117–128, Raven Press, New York.Google Scholar
  76. Gessa, G. L., Tagliamonte, A., Tagliamonte, P., and Brodie, B. B., 1970, Essential role of testosterone in the sexual stimulation induced by p-chlorophenylalanine in male animals, Nature 227:616.PubMedGoogle Scholar
  77. Ginton, A., 1976, Copulation in noncopulators: Effect of pCPA in male rats, Pharmacol. Biochem. Behav. 4:357.PubMedGoogle Scholar
  78. Gorski, R. A., 1974, The neuroendocrine regulation of sexual behavior, in: Advances in Psychobiology, Vol. 2 (G. Newton, and H. H. Riesen, eds), pp. 1–58, John Wiley and Sons, New York.Google Scholar
  79. Gradwell, P. B., Everitt, B. J., and Herbert, J., 1975, 5-Hydroxytryptamine in the central nervous system and sexual receptivity of female rhesus monkeys Brain Res 88:281.PubMedGoogle Scholar
  80. Grant, L. D., and Stumpf, W. E., 1973, Localization of 3H-estradiol and catecholamines in identical neurons in the hypothalamus,J. Histochem. Cytochem. 21:404.Google Scholar
  81. Grant, L. D., and Stumpf, W. E., 1975, Hormone uptake sites in relation to CNS biogenic amine systems, in: Anatomical Neuro endocrinology (W. E. Stumpf and L. D. Grant, eds.), pp. 445–463, Karger, Basel.Google Scholar
  82. Grant, L. D., Coscina, D. V., Grossman, S. P., and Freedman, D. X., 1973, Muricide after serotonin depleting lesions of midbrain raphe nuclei, Pharmacol. Biochem. Behav. 1:77.PubMedGoogle Scholar
  83. Gray, G. D., Davis, H. N., and Dewsbury, D. A., 1974, Effects of l-DOPA on the heterosexual copulatory behavior of male rats, Br. J. Pharmacol. 27:367.Google Scholar
  84. Grossman, S. P., 1972, Cholinergic synapses in the limbic system and behavioral inhibition, Res. Publ. Assoc. Res. Nerv. Ment. Dis. 50:315.PubMedGoogle Scholar
  85. Hardy, D. F., and DeBold, J. F., 1971, The relationship between levels of exogenous hormones and the display of lordosis by the female rat, Horm. Behav. 2:287.Google Scholar
  86. Harvey, J. A., Schlossberg, A. J., and Yunger, L. M., 1975, Behavioral correlates of serotonin depletion, Fed. Proc. 34:1796.PubMedGoogle Scholar
  87. Henrik, E., and Gerall, A. A., 1976, Facilitation of receptivity in estrogen-primed rats during successive mating tests with progestins and methysergide,J. Comp. Physiol. Psychol. 90: 590.PubMedGoogle Scholar
  88. Heritage, A. S., Grant, L. D., and Stumpf, W. E., 1977, 3H-estradiol in catecholamine neurons of rat brain stem: Combined localization by autoradiography and formaldehyde-induced fluorescence,J. Comp. Neurol. 176:607.PubMedGoogle Scholar
  89. Herndon, J. G., Jr., 1976, Effects of midbrain lesions on female sexual behavior in the rat, Physiol. Behav. 17:143.PubMedGoogle Scholar
  90. Herndon, J. G., Jr., Caggiula, A. R., Sharp, D., Ellis, D., Zigmond, M. J., and Redgate, E. S., 1976, Alterations in reproductive behavior patterns of female rats following administration of catecholamine-depleting drugs, Neurosci. Abstr. 2:851.Google Scholar
  91. Hery, F., Rouer, E., and Glowinski, J., 1972, Daily variations of serotonin metabolism in the rat brain, Brain Res. 43:445.PubMedGoogle Scholar
  92. Hetta, J., 1977, Effects of morphine and naltrexone on sexual behaviour of the male rat, Acta Pharmacol. Toxicol. 41(Suppl. IV): 53.Google Scholar
  93. Hollister, L. E., 1975a, Drugs and sexual behavior in man, Life Sci. 17:661.PubMedGoogle Scholar
  94. Hollister, L. E., 1975b, The mystique of social drugs and sex, in: Sexual BehaviorPharmacology and Biochemistry (M. Sandler and G. L. Gessa, eds.), pp. 85–92, Raven Press, New York.Google Scholar
  95. Hoyland, V. J., Shillito, E. E., and Vogt, M., 1970, The effect of parachlorophenylalanine on the behavior of cats, Br. J. Pharmacol. 40:659.PubMedGoogle Scholar
  96. Hyyppä, M., Lehtinen, P., and Rinne, U.K., 1971, Effect of l-DOPA on the hypothalamic, pineal and striatal monoamines and on the sexual behavior of the rat, Brain Res. 30:265.PubMedGoogle Scholar
  97. Hyyppä, M., Lampinen, P., and Lehtinen, P., 1972, Alteration in the sexual behavior of male and female rats after neonatal administration of p-chlorophenylalanine, Psychopharmacologia 25:152.PubMedGoogle Scholar
  98. Jacobowitz, D. M., and Palkovits, M., 1974, Topographic atlas of catecholamine and acetylcholinesterase-containing neurons in the rat brain. I. Forebrain (telencephalon, dience-phalon),J. Comp. Neurol. 157:13.PubMedGoogle Scholar
  99. Janowsky, D. S., and Davis, J. M., 1970, Progesterone-estrogen effects on uptake and release of norepinephrine by synaptosomes, Life Sci. 9:525.PubMedGoogle Scholar
  100. Jensen, E. V., and DeSombre, E. R., 1973, Estrogen-receptor interaction, Science 182:126.PubMedGoogle Scholar
  101. Kalra, P. S., and McCann, S. M., 1973, Involvement of catecholoamines in feedback mechanisms, Prog. Brain Res. 39:185.PubMedGoogle Scholar
  102. Kizer, J. S., Palkovits, M., Zivin, J., Brownstein, M., Saavedra, J. M., and Kopin, I. J., 1974, The effect of endocrinological manipulations on tyrosine hydroxylase activity in individual hypothalamic nuclei of the adult male rat, Endocrinology 95:799.PubMedGoogle Scholar
  103. Komisaruk, B. R., 1974, Neural and hormonal interactions in the reproductive behavior of female rats, in: Reproductive Behavior (M. Montagna and W. A. Sadler, eds.), pp. 97–129, Plenum Press, New York.Google Scholar
  104. Larsson, K., and Södersten, P., 1971, Lordosis behavior in male rats treated with estrogen in combination with tetrabenazine and nialamide, Psychopharmacologia 21:13.PubMedGoogle Scholar
  105. Larsson, K., Feder, H. H., and Komisaruk, B. R., 1974, Role of the adrenal glands, repeated matings, and monoamines in lordosis behavior of rats, Pharmacol. Biochem. Behav. 2:685.PubMedGoogle Scholar
  106. Lindström, L. H., 1970, The effect of pilocarpine in combination with monoamine oxidase inhibitors, imipramine or desmethylimipramine on oestrous behavior in female rats, Psychopharmacologia 17:160.PubMedGoogle Scholar
  107. Lindström, L. H., 1971, The effect of pilocarpine and oxotremorine on oestrous behavior in female rats after treatment with monoamine depletors or monoamine synthesis inhibitors, Eur. J. Pharmacol. 15:60.PubMedGoogle Scholar
  108. Lindström, L. H., 1972, The effect of pilocarpine and oxotremorine on hormone activated copulatory behavior in the ovariectomized hamster, Naunyn-Schmiedebergs Arch. Pharmacol. 275:233.PubMedGoogle Scholar
  109. Lindström, L. H., 1973, Further studies on cholinergic mechanisms and hormone-activated copulatory behavior in the female rat,J. Endocrinol. 56:275.PubMedGoogle Scholar
  110. Lindström, L. H., and Meyerson, B. J., 1967, The effect of pilocarpine, oxotremorine, and arecoline in combination with methyl-atropine or atropine on hormone-activated oestrous behavior in ovariectomized rats, Psychopharmacologia 11:405.PubMedGoogle Scholar
  111. Löfström, A., 1977, Catecholamine turnover alterations in discrete areas of the median eminence of the 4- and 5-day cyclic rat, Brain Res. 120:113.PubMedGoogle Scholar
  112. Löfström, A., Eneroth, P., Gustaffson, J.-A., and Skett, P., 1977, Effects of estradiol benzoate on catecholamine levels and turnover in discrete areas of the median eminence and the limbic forebrain, and on serum luteinizing hormone, follicle stimulating hormone and prolactin concentrations in the ovariectomized female rat, Endocrinology 101:1559.Google Scholar
  113. Luine, V. N., Khylchevskaya, R. I., and McEwen, B. S., 1975, Effect of gonadal steroids on activities of monoamine oxidase and choline acetylase in rat brain, Brain Res. 86:293.PubMedGoogle Scholar
  114. Luine, V. N., McEwen, B. S., and Black, I. B., 1977, Effect of 17β estradiol on hypothalamic tyrosine hydroxylase activity, Brain Res. 120:188.PubMedGoogle Scholar
  115. Malmnäs, C. O., 1973, Monoaminergic influence on testosterone-activated copulatory behavior in the castrated male rat. Acta Physiol, Scand. (Suppl.) 395:1Google Scholar
  116. Malmnäs, C. O., 1976, The significance of dopamine, versus other catecholamines, for l-DOPA induced facilitation of sexual behavior in the castrated male rat, Pharmacol. Biochem. Behav. 4:521.PubMedGoogle Scholar
  117. Malmnäs, C. O., 1977, Dopaminergic reversal of the decline after castration of rat copulatory behavior,J. Endocrinol. 73:187.PubMedGoogle Scholar
  118. Malmnäs, C. O., and Meyerson, B.J., 197l, p-Chlorophenylalanine and copulatory behavior in the male rat, Nature 232:398.Google Scholar
  119. Marshall, J. F., Richardson, J. S., and Teitelbaum, P., 1974, Nigrostriatal bundle damage and the lateral hypothalamic syndrome, J. Comp. Physiol. Psychol. 87:808.PubMedGoogle Scholar
  120. Marshall, J. M., 1970, Adrenergic innervation of the female reproductive tract: Anatomy, physiology and pharmacology, Ergeb. Physiol. 62:6.Google Scholar
  121. McEwen, B. S., 1976, Steroid receptors in neuroendocrine tissues: Topography, subcellular distribution, and functional implications, in: Subcellular Mechanisms in Reproductive Neuroendocrinology (F. Naftolin, K.J. Ryan, and J. Davies, eds.), pp. 277–304, Elsevier, Amsterdam.Google Scholar
  122. McEwen, B. S., Davis, P. G., Parsons, B., and Pfaff, D. W., 1979, The brain as a target for steroid hormone action, Annu. Rev. Neurosci. 2:65.PubMedGoogle Scholar
  123. Meyerson, B. J., 1964a, Central nervous monoamines and hormone induced estrus behavior in the spayed rat, Acta Physiol. Scand. (Suppl.) 248:5.Google Scholar
  124. Meyerson, B. J., 1964b, Estrus behavior in spayed rats after estrogen or progesterone treatment in combination with reserpine or tetrabenazine, Psychopharmacologia 6:210.PubMedGoogle Scholar
  125. Meyerson, B. J., 1964c, The effect of neuropharmacological agents on hormone-activated estrus behavior in ovariectomized rats, Arch. Int. Pharmacodyn. Ther. 150:4.PubMedGoogle Scholar
  126. Meyerson, B. J., 1966, The effect of imipramine and related antidepressive drugs on estrus behavior in ovariectomized rats activated by progesterone, reserpine, or tetrabenazine in combination with estrogen, Acta Physiol. Scand. 67:411.PubMedGoogle Scholar
  127. Meyerson, B. J., 1968a, Amphetamine and 5-hydroxytryptamine inhibition of copulatory behavior in the female rat, Ann. Med. Exp. Fenn. 46:394.PubMedGoogle Scholar
  128. Meyerson, B. J., 1968b, Female copulatory behavior in male and androgenized female rats after oestrogen/amine depletor treatment, Nature 217:683.PubMedGoogle Scholar
  129. Meyerson, B. J., 1970, Monoamines and hormone activated oestrous behavior in the ovariectomized hamster, Psychopharmacologia 18:50.PubMedGoogle Scholar
  130. Meyerson, B. J., and Lewander, T., 1970, Serotonin synthesis inhibition and estrous behavior in female rats, Life Sci. 9:661.Google Scholar
  131. Meyerson, B. J., and Lindstrom, L. H., 1973, Sexual motivation in the female rat, Acta Physiol. Scand. (Suppl.) 389:1.Google Scholar
  132. Meyerson, B. J., and Terenius, L., 1977, β-Endorphin and male sexual behavior, Eur. J. Pharmacol. 42:191.PubMedGoogle Scholar
  133. Meyerson, B. J., Eliasson, M., Lindström, L., Michanek, A., and Söderlund, A., 1973, Monoamines and female sexual behavior, in: Psychopharmacology, Sexual Disorders, and Drug Abuse (T. A. Ban, J. R. Boissier, G. J. Gessa, H. Heimann, L. Hollister, H. E. Lehmann, I. Munkvad, H. Steinberg, F. Sulser, A. Sundwall, and O. Vinar, eds.), pp. 463–472, North-Holland Publishing Co., Amsterdam.Google Scholar
  134. Meyerson, B. J., Carrer, H., and Eliasson, M., 1974, 5-hydroxytryptamine and sexual behavior in the female rat, Adv. Biochem. Psychopharmacol. 11:229.PubMedGoogle Scholar
  135. Michanek, A., and Meyerson, B. J., 1977, A comparative study of different amphetamines on copulatory behavior and stereotype activity in the female rat, Psychopharmacology 53:175.PubMedGoogle Scholar
  136. Mitler, M. M., Morden, B., Levine, S., and Dement, W., 1972, The effects of parachlorophenylalanine on the mating behavior of male rats, Physiol. Behav. 8:1147.PubMedGoogle Scholar
  137. Moltz, H., Rowland, D., Steele, M., and Halaris, A., 1976, Hypothalamic norepinephrine: Concentration and metabolism during pregnancy and lactation in the rat, Neuroendocrinology 19:252.Google Scholar
  138. Morin, L., and Feder, H. H., 1974a, Hypothalamic progesterone implants and facilitation of lordosis behavior in estrogen-primed ovariectomized guinea pigs, Brain Res. 70:84.Google Scholar
  139. Morin, L. P., and Feder, H. H., 1974b, Inhibition of lordosis behavior in ovariectomized guinea pigs by mesencephalic implants of progesterone, Brain Res. 70:71.PubMedGoogle Scholar
  140. Moss, R. L., 1978, Effects of hypothalamic peptides on sex behavior in animal and man, in: Psychopharmacology: A Generation of Progesss (M. A. Lipton, A. DiMascio, and K. F. Killam, eds.), pp. 431–440, Raven Press, New York.Google Scholar
  141. Moss, R. L., and Foreman, M. M., 1976, Potentiation of lordosis behavior by intrahypothalamic infusion of synthetic luteinizing hormone-releasing hormone, Neuroendocrinology 20:176.PubMedGoogle Scholar
  142. Moss, R. L., and McCann, S. M., 1973, Induction of mating behavior in rats by luteinizing hormone releasing factor, Science 181:177.PubMedGoogle Scholar
  143. Moss, R. L., and McCann, S. M., 1975, Action of luteinizing hormone-releasing factor (LRF) in the initiation of lordosis behavior in the estrone-primed ovariectomized female rat, Neuroendocrinology 17:309.PubMedGoogle Scholar
  144. Munaro, N. I., 1977, The effect of ovarian steroids on hypothalamic norepinephrine neuronal activity, Acta Endocrinol. (Kbh.) 86:235.Google Scholar
  145. Munaro, N. I., 1978, The effect of ovarian steroids on hypothalamic 5-hydroxytryptamine neuronal activity, Neuroendocrinology 26:270.PubMedGoogle Scholar
  146. Nausieda, P. A., Kaller, W. C., Weiner, W. J., and Klawans, H. L., 1979, Modification of postsynaptic dopaminergic sensitivity by female sex hormones, Life Sci. 25:521.PubMedGoogle Scholar
  147. Nixon, R. L., Janowsky, D. S., and Davis, J. M., 1974, Effects of progesterone, beta-estradiol and testosterone on the uptake and metabolism of 3H-norepinephrine, 3H-dopamine and 3H-serotonin in rat brain synaptosomes, Res. Commun. Chem. Pathol. Pharmacol. 7:233.PubMedGoogle Scholar
  148. Nock, B., and Feder, H. H., 1979, Noradrenergic transmission and female sexual behavior of guinea pigs, Brain Res. 66:369.Google Scholar
  149. O’Malley, B. W., and Means, A. R., 1974, Female steroid hormones and target cell nuclei, Science 183:610.PubMedGoogle Scholar
  150. Palkovits, M., and Jacobowitz, D. M., 1974, Topographic atlas of catecholamine and acetylcholinesterase-containing neurons in the rat brain II. Hindbrain (mesencephalon, rhombencephalon),J. Comp. Neurol. 157:29.PubMedGoogle Scholar
  151. Paris, C. A., Resko, J. A., and Goy, R. W., 1971, A possible mechanism for the induction of lordosis by reserpine in spayed rats, Biol. Reprod. 4:23.PubMedGoogle Scholar
  152. Pellegrini Quarantotti, B., Corda, M. G., Paglietti, E., Biggio, G., and Gessa, G. L., 1978, Inhibition of copulatory behavior in male rats by D-ala2-met-enkephalinamide, Life Sci. 23:673.Google Scholar
  153. Pfaff, D. W., 1973, Luteinizing hormone-releasing factor potentiates lordosis behavior in hypophysectomized, ovariectomized female rats, Science 182:1148.PubMedGoogle Scholar
  154. Pfaff, D. W., and Keiner, M., 1973, Atlas of estradiol-concentrating cells in the central nervous system of the female rat,J. Comp. Neurol 151:121.PubMedGoogle Scholar
  155. Pfaff, D., Lewis, C., Diakow, C., and Keiner, M., 1973, Neurophysiological analysis of mating behavior responses as hormone-sensitive reflexes, in: Progress in Physiological Psychology, Vol. 5 (E. Stellar and J. M. Sprague, eds.), pp. 253–297, Academic Press, New York.Google Scholar
  156. Pfaff, D., Montgomery, M., and Lewis, C., 1977, Somatosensory determinants of lordosis in female rats: Behavioral definition of the estrogen effect,J. Comp. Physiol. Psychol. 91:134.PubMedGoogle Scholar
  157. Redmond, D. E., Mass, J. W., Kling, A., Graham, C. W., and Dekirmenjian, H., 1971, Social behavior of monkeys selectively depleted of monoamines, Science 174:428.PubMedGoogle Scholar
  158. Rinaud, G. A., and Chew, C. S., 1975, Interacting effects of estrogen, progesterone, and catecholamines on rat uterine cyclic AMP and glycogen Phosphorylase, Life Sci. 16:1507.Google Scholar
  159. Roberts, J. M., Insel, P. A., Goldfien, R. D., and Goldfein, A., 1977, α-Adrenoreceptors but not β-adrenoreceptors increase in rabbit uterus with oestrogen, Nature 270:624.PubMedGoogle Scholar
  160. Rodriguez-Sierra, J. F., Naggar, A. N., and Komisaruk, B. R., 1976, Monoaminergic mediation of masculine and feminine copulatory behavior in female rats, Pharmacol. Biochem. Behav. 5:457.PubMedGoogle Scholar
  161. Rosenberg, P., Leidahl, L., Halaris, A., and Moltz, H., 1976, Changes in the metabolism of hypothalamic norepinephrine associated with the onset of maternal behavior in the nulliparous rat, Pharmacol. Biochem. Behav. 4:647.PubMedGoogle Scholar
  162. Rosenberg, P., Halaris, A., and Moltz, A., 1977, Effects of norepinephrine depletion on the initiation and maintainance of maternal behavior in the rat, Pharmacol. Biochem. Behav. 6:21.PubMedGoogle Scholar
  163. Sachs, B. D., and Barfield, R. J., 1976, Functional analysis of masculine copulatory behavior in the rat, in: Advances in the Study of Behavior (J. S. Rosenblatt, R. A. Hinde, E. Shaw, and C. Beer, eds.), pp. 91–154, Academic Press, New York.Google Scholar
  164. Salis, P. J., and Dewsbury, D. A., 1971, p-Chlorophenylalanine facilitates copulatory behavior in male rats, Nature 232:400.PubMedGoogle Scholar
  165. Sailer, C. F., and Stricker, E. M., 1976, Hyperphagia and increased growth in rats after intraventricular injection of 5, 7-dihydroxytryptamine, Science 192:385.Google Scholar
  166. Sar, M., and Stumpf, W. E., 1975, Distribution of androgen-concentrating neurons in rat brain, in: Anatomical Neuro endocrinology (W. E. Stumpf and L. D. Grant, eds.), pp. 120–133, Karger, Basel.Google Scholar
  167. Shillito, E. E., 1970, The effect of parachlorophenylalanine on social interaction of male rats, Br. J. Pharmacol. 38:305.Google Scholar
  168. Sicuteri, F., 1974, Serotonin and sex in man, Pharmacol. Res. Commun. 6:403.PubMedGoogle Scholar
  169. Simpkins, J. W., Kalra, P. S., and Kalra, S. P., 1980, Effects of testosterone on catecholamine turnover and LHRH contents in the basal hypothalamus and preoptic area, Neuro endocrinology 30:94.Google Scholar
  170. Södersten, P., and Ahlenius, S., 1972, Female lordosis behavior in estrogen-primed male rats treated with p-chlorophenylalanine or alpha-methyl-p-tyrosine, Horm, Behav. 3:181.Google Scholar
  171. Södersten, P., Berge, O. G., and Hole, L., 1978, Effects of p-chloroamphetamine and 5,7-dihydroxytryptamine on the sexual behavior of gonadectomized male and female rats, Pharmacol. Biochem. Behav. 9:499.PubMedGoogle Scholar
  172. Soulairac, A., and Soulairac, M.-L., 1961, Action de la réserpine sur le comportement sexuel du rat mâle, C. R. Soc. Biol. (Paris) 155:1010.Google Scholar
  173. Soulairac, A., and Soulairac, M.-L., 1962, Effets de l’administration chronique de réserpine sur le comportement sexuel du rat mâle, Ann. Endocrinol. 23:281.Google Scholar
  174. Soulairac, A., and Soulairac, M.-L., 1971, Action de la serotonin sur le comportement sexuel du rat mâle, C. R. Soc. Biol. (Paris) 165:253.Google Scholar
  175. Soulairac, M.-L., 1963, Étude expérimentale des régulations hormono-nerveuses de comportement sexuel du rat mâle, Ann. Endocrinol. 24 (Suppl. 1):1.Google Scholar
  176. Soulairac, M.-L., and Soulairac, Å., 1975, Monoaminergic and cholinergic control of sexual behavior in the male rat, in: Sexual BehaviorPharmacology and Biochemistry (M. Sandler and G. L. Gessa, eds.), pp. 99–116, Raven Press, New York.Google Scholar
  177. Stein, L., Wise, C. D., and Berger, B. D., 1973, Antianxiety action of benzodiazepines: Decrease in activity of serotonin neurons in the punishment system, in, The Benzodiazepines (S. Garratini, ed.), pp. 299–325, Raven Press, New York.Google Scholar
  178. Stumpf, W. E., Sar, M., and Keefer, D. A., 1975, Atlas of estrogen target cells in rat brain, in: Anatomical Neuroendocrinology (W. E. Stumpf, and L. D. Grant, eds.), pp. 104–119, Karger, Basel.Google Scholar
  179. Tagliamonte, A., Tagliamonte, P., Gessa, G. L., and Brodie, B. B., 1969, Compulsive sexual activity induced by p-chlorophenylalanine in normal and pinealectomized male rats, Science 166:1433.PubMedGoogle Scholar
  180. Tagliamonte, A., Fratta, W., del Fiacco, M., and Gessa, G. L., 1974, Possible stimulatory role of brain dopamine in the copulatory behavior of male rats, Pharmacol. Biochem. Behav. 2:257.PubMedGoogle Scholar
  181. Uphouse, L. L., Wilson, J. R., and Schlesinger, K., 1970, Induction of estrus in mice: The possible role of adrenal progesterone, Horm. Behav. 1:255.Google Scholar
  182. Van de Poll, N. E., Van Dis. H., and Bermond, B., 1977, The induction of mounting behavior in female rats by p-chlorophenylalanine, Eur. J. Pharmacol. 41:225.PubMedGoogle Scholar
  183. Van Loon, G. R., 1973, Brain catecholamines and ACTH secretion, in: Frontiers in Neuroendocrinology (W. F. Ganong and L. Martini, Eds.), pp. 209–247, Oxford University Press, New York.Google Scholar
  184. Ward, I. L., 1972, Female sexual behavior in male rats treated prenatally with an anti-androgen, Physiol. Behav. 8:53.PubMedGoogle Scholar
  185. Ward, I. L., Crowley, W. R., Zemlan, F. P., and Margules, D. L., 1975, Monoaminergic mediation of female sexual behavior,J. Comp. Physiol. Psychol. 88:53.PubMedGoogle Scholar
  186. Weiner, R. I., and Ganong, W. F., 1978, Role of brain monoamines and histamine on regulation of anterior pituitary secretion, Physiol. Rev. 58:905.PubMedGoogle Scholar
  187. Whalen, R. E., Gorzalka, B., and DeBold, J. F., 1975, Methodologic considerations in the study of animal sexual behavior, in: Sexual Behavior: Pharmacology and Biochemistry (M. Sandler and G. L. Gessa, eds.), pp. 33–50, Raven Press, New York.Google Scholar
  188. Wirz-Justice, A., Hackmann, E., and Lichsteiner, M., 1974, The effect of oestradiol dipropionate and progesterone on monoamine uptake in rat brain,J. Neurochem. 22:187.PubMedGoogle Scholar
  189. Wise, C. D., Berger, B. D., and Stein, L., 1973, Evidence of alpha-noradrenergic reward receptors and serotonergic punishment receptors in the rat brain, Biol. Psychiatry 6:3.PubMedGoogle Scholar
  190. Young, W. C., 1961, The hormones and mating behavior, in: Sex and Internal Secretions, Vol. II (W. C. Young, ed.), pp. 1173–1239, Williams & Wilkins, Baltimore.Google Scholar
  191. Young, W. C., 1969, Psychobiology of sexual behavior in the guinea pig, in: Advances in the Study of Behavior (D. S. Lehrman, R. A. Hinde, and E. Shaw, eds.), pp. 1–110, Academic Press, New York.Google Scholar
  192. Zemlan, F. P., 1978, The influence of p-chloroamphetamine and p-chlorophenylalanine on female mating behavior, Am. N. Y. Acad. Sci 305:621.Google Scholar
  193. Zemlan, F. P., and Adler, N. T., 1977, Hormonal control of female reproductive behavior in the rat, Horm. Behav. 9:345.PubMedGoogle Scholar
  194. Zemlan, F. P., Ward, I. L., Crowley, W. R., and Margules, D. L., 1973, Activation of lordotic responding in female rats by suppression of serotonergic activity, Science 179:1010.PubMedGoogle Scholar
  195. Zemlan, F. P., Trulson, M. E., Howell, R., and Hoebel, B. G., 1977, Influence of p-chloroamphetamine on female sexual reflexes and brain monoamine levels, Brain Res. 123:347.PubMedGoogle Scholar
  196. Zigmond, M. J., and Stricker, E. M., 1974, Ingestive behavior following damage to central dopamine neurons: Implications for homeostasis and recovery of function, in: Neurop-sychopharmacology of Monoamines and their Regulatory Enzymes (E. Usdin, ed.), pp. 385–402, Raven Press, New York.Google Scholar
  197. Zitrin, A., Beach, F. A., Barchas, J. D., and Dement, W. C., 1970, Sexual behavior of male cats after administration of parachlorophenylalanine, Science 170:868.PubMedGoogle Scholar
  198. Zucker, J., 1966, Facilitatory and inhibitory effects of progesterone on sexual responses of spayed guinea pigs,J. Comp. Physiol. Psychol. 62:376.Google Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • William R. Crowley
    • 1
  • Frank P. Zemlan
    • 2
  1. 1.Department of PharmacologyUniversity of Tennessee Center for the Health SciencesMemphisUSA
  2. 2.Department of PharmacologyUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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