Serotonin pp 177-189 | Cite as

Descending Control of Pain Transmission: Possible Serotonergic-Enkephalinergic Interactions

  • Allan I. Basbaum
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 133)


To a somewhat suprising extent, many recent advances in our understanding of the role of serotonin in pain modulation derive more from anatomical and physiological studies than from pharmacological and behavioral analyses. This has resulted, in part, from the development of new anatomical methods for the localization of CNS monoamines. Concurrently, the development of methods for the localization of putative CNS transmitter peptides has allowed an analysis of possible interactions between, for example, serotonin, enkephalin and substance P.


Dorsal Horn Spinal Dorsal Horn Pain Transmission Superficial Dorsal Horn Trigeminal Nucleus Caudalis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Allan I. Basbaum
    • 1
  1. 1.Department of AnatomyUniversity of California, San FranciscoSan FranciscoUSA

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