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Serotonin pp 177–189Cite as

Descending Control of Pain Transmission: Possible Serotonergic-Enkephalinergic Interactions

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 133))

Abstract

To a somewhat suprising extent, many recent advances in our understanding of the role of serotonin in pain modulation derive more from anatomical and physiological studies than from pharmacological and behavioral analyses. This has resulted, in part, from the development of new anatomical methods for the localization of CNS monoamines. Concurrently, the development of methods for the localization of putative CNS transmitter peptides has allowed an analysis of possible interactions between, for example, serotonin, enkephalin and substance P.

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Author information

Authors and Affiliations

  1. Department of Anatomy, University of California, San Francisco, Room 1334-S, San Francisco, California, 94143, USA

    Allan I. Basbaum

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  1. Allan I. Basbaum
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Editor information

Editors and Affiliations

  1. The University of Texas Medical Branch, Galveston, Texas, USA

    Bernard Haber

  2. Veterans Administration Medical Center, Brockton, Massachusetts, USA

    Sabit Gabay

  3. Brown University Division of Psychiatry and Human Behavior, Providence, Rhode Island, USA

    Sabit Gabay

  4. University of Athens School of Medicine, Athens, Greece

    M. R. Issidorides  & S. G. A. Alivisatos  & 

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© 1981 Plenum Press, New York

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Basbaum, A.I. (1981). Descending Control of Pain Transmission: Possible Serotonergic-Enkephalinergic Interactions. In: Haber, B., Gabay, S., Issidorides, M.R., Alivisatos, S.G.A. (eds) Serotonin. Advances in Experimental Medicine and Biology, vol 133. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3860-4_9

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  • DOI: https://doi.org/10.1007/978-1-4684-3860-4_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3862-8

  • Online ISBN: 978-1-4684-3860-4

  • eBook Packages: Springer Book Archive

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