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Serotonin pp 153–176Cite as

Role of the Raphe Nuclei in Stimulation Producing Analgesia

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 133))

Abstract

There are now many studies demonstrating that electrical stimulation of certain regions of the brain stem produces analgesia in a variety of animals. After the original report of Reynolds1 showing that stimulation of the periaqueductal gray matter (PAG) produced analgesia in the rat these observations were confirmed and extended to other species, the cat, monkey and man (see refs in 2,3,4,5). The majority of the studies mostly in the rat, were concerned with the PAG and neighbouring periventricular areas. However in our laboratory extensive mapping studies of over 300 stimulations sites in the chronic cat6,7,8,9,10,11,12 have extented over the whole brain stem between the mesencephalon and the medulla. These studies demonstrate the essential role of the serotonin containing raphé nuclei in these analgesic phenomena. In this paper we will successively consider :

  • these behavioral studies on stimulation produced analgesia and

  • electrophysiological studies on the neural correlates of the analgesia observed in the chronic experiments.

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Authors and Affiliations

  1. Unité de Recherches de Neurophysiologie Pharmacologique, I.N.S.E.R.M., Unité 161, 2, rue d’Alésia, 75014, Paris, France

    Jean-Marie Besson, Jean-Louis Oliveras, Athmane Chaouch & Jean-Paul Rivot

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  1. Jean-Marie Besson
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  2. Jean-Louis Oliveras
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  3. Athmane Chaouch
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  4. Jean-Paul Rivot
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Editors and Affiliations

  1. The University of Texas Medical Branch, Galveston, Texas, USA

    Bernard Haber

  2. Veterans Administration Medical Center, Brockton, Massachusetts, USA

    Sabit Gabay

  3. Brown University Division of Psychiatry and Human Behavior, Providence, Rhode Island, USA

    Sabit Gabay

  4. University of Athens School of Medicine, Athens, Greece

    M. R. Issidorides  & S. G. A. Alivisatos  & 

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© 1981 Plenum Press, New York

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Besson, JM., Oliveras, JL., Chaouch, A., Rivot, JP. (1981). Role of the Raphe Nuclei in Stimulation Producing Analgesia. In: Haber, B., Gabay, S., Issidorides, M.R., Alivisatos, S.G.A. (eds) Serotonin. Advances in Experimental Medicine and Biology, vol 133. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3860-4_8

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  • DOI: https://doi.org/10.1007/978-1-4684-3860-4_8

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