Effects of Peripherally and Centrally Administered Serotonin on Primate Spinothalamic Neurons
Serotonin has actions at several different levels of the neural system responsible for nociception. When injected into the arterial circulation of a muscle, serotonin excites small myelinated and unmyelinated fibers supplying nociceptors (Mense & Schmidt, 1974; Fock & Mense, 1976; Mense, 1977). Serotonin is thus an algesic agent in terms of its peripheral action. By contrast, serotonin is thought to be one of the synaptic transmitters in the central nervous system pathways that mediate stimulation-produced analgesia (Akil & Mayer, 1972; Akil & Liebeskind, 1975; Yaksh, 1979; Yaksh & Wilson, 1979).
KeywordsReceptive Field Dorsal Horn Spinothalamic Tract Iontophoretic Application Cutaneous Input
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