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Serotonin pp 753-767 | Cite as

Serotonin and Dopamine Disturbances in Patients with Unipolar Depressin and Parkinsonism

  • Julien Mendlewicz
  • Jean-Emile Vanderheyden
  • Guy Noel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 133)

Summary

Probenecid was administered to 7 unipolar depressed patients, 7 parkinsonians and 7 extrapyramidal patients with senile dementia matched for age and sex. Before and after the administration of probenecid, the levels of 5 hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) were determined in the cerebrospinal fluid (CSF) of all patients in order to study the central turnover rate of serotonin and dopamine. Unipolar depressed patients showed a significantly lower increase in CSF 5HIAA levels after probenecid than parkinsonians. Patients with Parkinsonism had a reduced increment of CSF HVA levels following probenecid administration when compared to unipolar depressed and extrapyramidal patients with senile dementia.

Keywords

Biogenic Amine Senile Dementia Parkinsonian Patient Unipolar Depression Decarboxylase Inhibitor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Julien Mendlewicz
    • 1
    • 2
  • Jean-Emile Vanderheyden
    • 1
    • 2
  • Guy Noel
    • 1
    • 2
  1. 1.Department of PsychiatryErasme HospitalBrusselsBelgium
  2. 2.C.G.T.R. Rayon de SoleilCollège Direction MédicaleMontignies-le-TilleulBelgium

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