Skip to main content

Studies of CSF 5-HIAA in Depression and Suicidal Behaviour

  • Chapter
Serotonin

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 133))

Abstract

A role for serotonin in the development of depressive illness has been suggested since the sixties (e.g. by Lapin and Oxenkrug 1969). Evidence for the importance of the neurotransmitter has largely been indirect and drawn, inter al., from pharmacological data. Many antidepressant treatments have effects on serotonin neurons. The monoamine oxidase inhibitors and some of the tricyclic antidepressants potentiate serotonergic functions, and recently this was found to be true also for convulsive treatments (Green and Grahame-Smith 1978).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Asberg, M. and Bertilsson, L., 1979, in: “Neuropsychopharmacology”, B. Saletu, ed., Pergamon Press, Oxford and New York. P. 105.

    Google Scholar 

  • Asberg, M. and Sjöqvist, F., 1978, On the role of plasma level monitoring of tricyclic antidepressants in clinical practice, Commun.Psychopharmacol. 2: 381.

    PubMed  CAS  Google Scholar 

  • Asberg, M., Bertilsson, L., Tuck, D., Cronholm, B. and Sjöqvist, F., 1973, Indoleamine metabolites in the cerebrospinal fluid of depressed patients before and during treatment with nortriptyline, Clin.Pharmacol. Ther. 14: 277.

    PubMed  CAS  Google Scholar 

  • Asberg, M., Thorén, P., Träskman, L., Bertilsson, B. and Ringberger, V.-A., 1976A, “Serotonin Depression” - A biochemical subgroup within the affective disorders?, Science 191: 478.

    Article  PubMed  CAS  Google Scholar 

  • Asberg, M., Träskman, L. and Thorén, P., 1976, 5-HIAA in the Cerebrospinal Fluid - A biochemical suicide predictor?, Arch.Gen.Psychiat. 33: 1193.

    Article  PubMed  CAS  Google Scholar 

  • Asberg, M., Ringberger, V.-A., Sjöqvist, F., Thorén, P., Träskman, L. and Tuck, J.R., 1977, Monoamine metabolites in cerebrospinal fluid and serotonin uptake inhibition during treatment with chlorimipramine, Clin.Pharmacol. Ther. 21: 201.

    PubMed  CAS  Google Scholar 

  • Asberg, M., Bertilsson, L., Thorgn, P. and Träskman, L., 1978, in: “Depressive Disorders: Symposium in Rome May 9–11 1977”, S. Garattini, ed., Schattauer, Stuttgart and New York. P. 293.

    Google Scholar 

  • Ashcroft, G.W., Crawford, T.B.B., Eccleston, D., Sharman, D.F., McDougall, E.J., Stanton, J.B. and Binns, J.K., 1966, 5-Hydroxyindole compounds in the cerebrospinal fluid of patients with psychiatric or neurological diseases, Lancet 11: 1049.

    Article  Google Scholar 

  • Bertilsson, L., 1973, Quantitative determination of 4-hydroxy3-methoxyphenyl glycol and its conjugates in cerebrospinal fluid by mass fragmentography, J. Chromatogr. 87: 147.

    Article  PubMed  CAS  Google Scholar 

  • Bertilsson, L. and Palmér, L., 1973, Determination of isomeric acid dopamine metabolites by mass fragmentography, Life Sciences 13: 859.

    Article  PubMed  CAS  Google Scholar 

  • Bertilsson, L., Atkinson, A.J.Jr., Althaus, J.R., Härfast, A., Lindgren, J.-E, and Holmstedt, B., 1972, Quantitative determination of 5-hydroxyindole-3-acetic acid in cerebrospinal fluid by gas chromatography-mass spectrometry, Analyt.Chem. 44: 1434.

    Article  CAS  Google Scholar 

  • Bertilsson, L., Asberg, M. and Thorén, P., 1974, Differential effect of chlorimipramine and nortriptyline on cerebrospinal fluid metabolites of serotonin and noradrenaline in depression, Eur.J.Clin.Pharmacol. 7: 365.

    Article  PubMed  CAS  Google Scholar 

  • Bowers, M.B.Jr., 1972B, Cerebrospinal fluid 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) following probenecid in unipolar depressives treated with amitriptyline, Psychopharmacol. 23: 26.

    Article  CAS  Google Scholar 

  • Brown, G.L., Ballanger, J.C., Minichiello, M.D. and Goodwin, F.K., 1979, in: “Psychopharmacology of aggression”, M. Sandler, ed., Raven Press, New York. P. 131.

    Google Scholar 

  • Buchsbaum, M.S., Coursey, R.D. and Murphy, D.L., 1976, The biochemical high-risk paradigm: behavioral and familial correlates of low platelet monoamine oxidase activity, Science 194: 339.

    Article  PubMed  CAS  Google Scholar 

  • Buchsbaum, M.S., Beier, R.J. and Murphy, D.L., 1977, Suicide attempts platelet monoamine oxidase and the average evoked response, Acta psychiat. Scand. 56: 69.

    Article  PubMed  CAS  Google Scholar 

  • Bunney, W.E.Jr., Fawcett, J.A., Davis, J.M. and Gifford, S., 1965, Further evaluation of urinary 17-hydroxycorticosteroids in suicidal patients. Arch.Gen.Psychiat. 21: 138.

    Article  Google Scholar 

  • Carroll, B.J., Curtis, G.C. and Mendel, J., 1976, Neuroendocrine regulation in depression. I. Limbic system - adrenocortical dysfunction. Arch.Gen.Psychiat. 33: 1039.

    Article  PubMed  CAS  Google Scholar 

  • Cowdry, R.W. and Goodwin, F.K., 1978, in: “Clinical Issues in Psychiatric Diagnosis”, R.L. Spiker and D.F. Klein, eds., Raven Press, New York. P. 281.

    Google Scholar 

  • Curzon, G., 1972, Relationships between stress and brain 5-hydroxytryptamine and their possible significance in affective disorders, J.Psychiat.Res. 9: 243.

    Article  PubMed  CAS  Google Scholar 

  • Delini-Stula, A. and Vassout, A., 1979, in: “Psychopharmacology of Aggression”, M. Sandler, ed., Raven Press, New York. P. 41.

    Google Scholar 

  • Eichelman, B., in: “Psychopharmacology of Aggression”, M. Sandler, ed., Raven Press, New York. P. 61.

    Google Scholar 

  • Dencker, S.J., Malm, U., Roos, B.-E. and Werdinius, B., 1966, Acid monoamine metabolites of cerebrospinal fluid in mental depression and mania, J.Neurochem. 13: 1545.

    Article  PubMed  CAS  Google Scholar 

  • Gottfries, C.-G., Gottfries, I., Johansson, B., Olsson, R., Persson, T., Roos, B. E. and Sjöström, R., 1971, Acid monoamine metabolites in human cerebrospinal fluid and their relations to age and sex, Neuropharmacology 10: 665.

    Article  PubMed  CAS  Google Scholar 

  • Gottfries, C.-G., Oreland, L., Wiberg, A. and Winblad, B.,1975, Lowered monoamine oxidase activity in brains from alcoholic suicides, J.Neurochem. 25: 667.

    Article  PubMed  CAS  Google Scholar 

  • Gottfries, C.-G., von Knorring, L. and Oreland, L., in press, Platelet monoamine oxidase activity in mental disorders. 2. Affective psychoses and suicidal behaviour. Progr. Neuro-Psychopharmacol. 4.

    Google Scholar 

  • Green, A.R. and Grahame-Smith, D.G., 1978, Processes regulating the functional activity of brain 5-hydroxytryptamine: Results of animal experimentation and their relevance to the understanding and treatment of depression, Pharmachopsychiatrie 11: 3.

    Article  Google Scholar 

  • Gurney, C., Roth, M., Garside, R.F., Kerr, T.A. and Schapira, K., 1972, Studies in the classification of affective disorders. The relationship between anxiety states and depressive illnesses - II, Brit. J. Psychiat. 121: 162.

    Article  PubMed  CAS  Google Scholar 

  • Lapin, I.P. and Oxenkrug, G.F., 1969, Intensification of the central serotoninergic processes as a possible determinant of the thymoleptic effect, Lancet 1: 132.

    Article  PubMed  CAS  Google Scholar 

  • Major, L.F., Murphy, D.L., Lipper, S. and Gordon, E., 1979, Effects of clorgyline and pargyline on deaminated metabolites of norepinephrine, dopamine and serotonin in human cerebrospinal fluid, J.Neurochem. 32: 229.

    Article  PubMed  CAS  Google Scholar 

  • Moir, A.T.B., Ashcroft, G.W., Crawford, T.B.B., Eccleston, D. and Guldberg, H.C., 1970., Cerebral metabolites in cerebrospinal fluid as a biochemical approach to the brain, Brain 93: 357.

    Article  PubMed  CAS  Google Scholar 

  • Murphy, D.L., Campbell, I.C. and Costa, J.L., 1978, The brain serotonergic system in the affective disorders. Progr. Neuro-Psychopharmacol. 2: 1.

    Article  Google Scholar 

  • Oreland, L., Wiberg, A., Asberg, M., Träskman, L., Sjöstrand, L., Thorén, P., Bertilsson, L. and Tybring, G., submitted for publication, Platelet MAO-activity and monoamine metabolites in cerebrospinal fluid in depressed and suicide patients and in healthy controls.

    Google Scholar 

  • Papeschi, R. and McClure, D.J., 1971, Homovanillic acid and 5-hydroxy-indoleacetic acid in cerebrospinal fluid of depressed patients, Arch.Gen.Psychiat. 25: 354.

    Article  PubMed  CAS  Google Scholar 

  • Potter, W.Z., Bertilsson, L. and Sjöqvist, F., in press, in: “Handbook of Biological Psychiatry”, H.M. van Praag et al, eds., Marcel Dekker, New York and Basel.

    Google Scholar 

  • Sachar, E.J., 1976, in: “Topics in psychoendocrinology”, E.J. Sachar, ed., Grune and Stratton, New York. P. 135.

    Google Scholar 

  • Sjöquist, B. and Johansson, B., 1978, A comparison between fluorometric and mass fragmentographic determinations of homovanillic acid and 5-hydroxy-indoleacetic acid in human cerebrospinal fluid, J.Neurochem. 31: 621.

    Article  PubMed  Google Scholar 

  • Sjöström, R., Ekstedt, J. and Änggârd, E., 1975, Concentration gradients of monoamine metabolites in human cerebrospinal fluid, J.Neurol., Neurosurg. and Psychiatry 38: 666.

    Article  Google Scholar 

  • Thorén, P., Asberg, M., Bertilsson, L., Mellström, B., Sjöqvist, F. and Träskman, L., in press, Chlorimipramine treatment of obsessive compulsive disorder. II. Biochemical aspects, Arch.Gen.Psychiat.

    Google Scholar 

  • Träskman-Bendz, L., 1980, Depression and suicidal behaviour - a biochemical and pharmacological study, Academic Dissertation, Stockholm.

    Google Scholar 

  • Träskman, L., Asberg, M., Bertilsson, L., Cronholm, B., Mellström, B., Neckers, L.M., Sjöqvist, F., Thorén, P. and Tybring, G., 1979, Plasma levels of chlorimipramine and its demethylmetabolite during treatment of depression. Differential biochemical and clinical effects of the two compounds. Clin.Pharmacol.Ther. 26: 600.

    PubMed  Google Scholar 

  • Träskman, L., Asberg, M., Bertilsson, L. and Sjöstrand, L., submitted for publication, Monoamine metabolites in cerebrospinal fluid and suicidal behaviour.

    Google Scholar 

  • Träskman, L., Tybring, G., Asberg, M., Bertilsson, L., Lantto, O. and Schalling, D., in press, CSF cortisol in depressed and suicide patients. Arch.Gen.Psychiat.

    Google Scholar 

  • Weiner, R.I. and Ganong, W.F., 1978, Role of brain monoamines and histamine in regulation of anterior pituitary secretion, Physiol.Reviews 58: 905.

    CAS  Google Scholar 

  • Wode Helgodt, B. and Sedvall, G., 1978, Correlations between height of subject and concentrations of monoamine metabolites in cerebrospinal fluid from psychotic men and women. Commun.Psychopharmaco1. 2: 177.

    Google Scholar 

  • Wode-Helgodt, B., Fyrö, B., Gullberg, B. and Sedvall, G., 1977, Effect of chlorpromazine treatment on monoamine metabolite levels in cerebrospinal fluid of psychotic patients, Acta psychiat. Scand. 56: 129.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Plenum Press, New York

About this chapter

Cite this chapter

Åsberg, M., Träskman, L. (1981). Studies of CSF 5-HIAA in Depression and Suicidal Behaviour. In: Haber, B., Gabay, S., Issidorides, M.R., Alivisatos, S.G.A. (eds) Serotonin. Advances in Experimental Medicine and Biology, vol 133. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3860-4_41

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-3860-4_41

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3862-8

  • Online ISBN: 978-1-4684-3860-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics