Serotonin pp 603-625 | Cite as

Serotonin Metabolism of Animal Model of Depression

  • R. Takahashi
  • T. Tateishi
  • H. Yoshida
  • H. Nagayama
  • K. H. Tachiki
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 133)


Undoubtedly psychopathological research of mental patients is one indispensable, important method for clarifying the etiology of mental disorders, depression for example. However the fact that the object is a living person causes apparently methodological demerits or limitations. For example, a strictly controlled study which requires normal human controls or a study using various chemicals in the patients is extremely difficult. Direct analysis of pathological process in the brain of human patients is almost impossible. Even the observation and analysis of symptomatology can hardly obtain universally valid components because of the complex background factors involved. In this connection an animal model is strongly required in the etiological research of depression because it is expected that the problems mentioned above in the methodology could be avoided in an animal model study. By employing an animal model both a simplication of various factors like premorbid personality, social environments and interpersonal relationship and experiments requiring a number of controls and many kinds of operation become possible. Therefore several kinds of animal model of depression have been reported and used for research of depression. The Table 1 shows a series of animal models of depression published so far over the world.1–11 These are self-explanatory.


Conditioned Stimulus Locomotor Activity Unconditioned Stimulus Conditioned Response Synaptic Membrane 


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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • R. Takahashi
    • 1
  • T. Tateishi
    • 1
  • H. Yoshida
    • 1
  • H. Nagayama
    • 1
  • K. H. Tachiki
    • 2
  1. 1.Department of NeuropsychiatryNagasaki University School of MedicineNagasaki 852Japan
  2. 2.Neurochemistry LaboratoriesVeterans Administration HospitalSepulvedaUSA

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