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Serotonergic-Dopaminergic Interactions: Implications for Hyper-Kinetic Disorders

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Serotonin

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 133))

Abstract

The elucidation of the neurochemical basis of movement disorders is currently one of the most challenging and important preclinical research endeavors. One very promising area of investigation concerns the role of serotonin (5-HT) in the control of neuromotor as well as behavioral activities. As a putative neurotransmitter, 5-HT has been implicated in such diverse activities as sleep (Jouvet, 1969; Jouvet and Pujol, 1974), learned and approach behavior (Aprison and Hingtgen, 1970, 1972; Aprison et al., 1975), aggression (Valzelli, 1974), sexual behavior (Gessa and Tagliamonte, 1974), operant or goal-directed behavior (Stein and Wise, 1974) and temperature regulation (Feldberg and Myers, 1964). On the basis of their earlier pharmacological findings, Brodie and Shore (1957) postulated the existence of two opposing systems regulating various brain functions, one catecholaminergic and the other serotonergic. More recent studies, however, have indicated that the relationship between 5-HT and the catecholamines is most likely one of mutual interaction rather than antagonistic opposition (Samanin and Garattini, 1975).

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Authors and Affiliations

  1. Biochemical Research Laboratory, VA Medical Center, Brockton, MA, 02401, USA

    Sabit Gabay

  2. Section of Psychiatry and Human Behavior, Brown University, Providence, R.I., USA

    Sabit Gabay

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  1. Sabit Gabay
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Editors and Affiliations

  1. The University of Texas Medical Branch, Galveston, Texas, USA

    Bernard Haber

  2. Veterans Administration Medical Center, Brockton, Massachusetts, USA

    Sabit Gabay

  3. Brown University Division of Psychiatry and Human Behavior, Providence, Rhode Island, USA

    Sabit Gabay

  4. University of Athens School of Medicine, Athens, Greece

    M. R. Issidorides  & S. G. A. Alivisatos  & 

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© 1981 Plenum Press, New York

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Gabay, S. (1981). Serotonergic-Dopaminergic Interactions: Implications for Hyper-Kinetic Disorders. In: Haber, B., Gabay, S., Issidorides, M.R., Alivisatos, S.G.A. (eds) Serotonin. Advances in Experimental Medicine and Biology, vol 133. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3860-4_33

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  • DOI: https://doi.org/10.1007/978-1-4684-3860-4_33

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3862-8

  • Online ISBN: 978-1-4684-3860-4

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