The Interaction of Indole Derivatives with the Serotonin Receptor and Non-Dopaminergic Circling Behaviour
Circling behaviour applied to the study of dopaminergic mechanisms in the brain has been up to now a most fruitful pharmacological procedure and all its possibilities have certainly not been explored. It is however more and more evident that other neurotransmitters can also contribute to the expression of this behaviour. The recent demonstrations of the important role of GABA in the substantia nigra is one example (Scheel-Krüger et al. 1977; Waddington 1977; Oberlander et al. 1977) and the results obtained with novel series of piperidinyl indoles and tetrahydropyridinyl indoles (∆ 3,4) (Dumont et al. 1976; Nédelec et al. 1978), the general structure of which is shown in figure 1, is another. These compounds can be considered as semi-rigid serotonin analogues in which the side chain N atom is further away from the indole nucleus than it would be in the most stable conformations of serotonin itself (P. Hunt, L. Nédelec in preparation).
KeywordsKainic Acid Hill Coefficient Indole Derivative Rotational Behaviour Serotonin Agonist
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