Serotonin pp 459-476 | Cite as

Neurohumor Substances as Neural Growth Factors

  • Antonia Vernadakis
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 133)


Neural growth and differentiation is regulated by genetic and epigenetic factors. Although genetic regulation is only recently beginning to be explored, intrinsic epigenetic control of neural growth has been the focus of research for several investigators. The regulatory role of hormones such as thyroid hormones and steroid hormones in neural growth and differentiation has been well documented. More recently, we (Vernadakis and Gibson, 1974) and others (Lauder, 1979) have proposed that neurohumor substances such as acetylcholine, catecholamines and indolamines are involved in cellular processes including neuro-genesis before their involvement in neurotransmitter processes. As it has been abundantly demonstrated with hormones, it is probably the combination of actions and interaction of several neurohumor substances that influence cellular growth. Moreover, neuronalglial interrelationships and the influence of neurohumor substances thereon are important factors in neural growth and differentiation. Lauder and associates will discuss in this symposium their work with serotonin on neurogenesis. We will discuss primarily the role of norepinephrine in neural growth. We have used the chick embryo as an animal model to study maturational processes at the organismic level and neural culture to characterize differential responses of neurons and glial cells to neurohumor substances.


Glial Cell Chick Embryo AChE Activity Neural Growth Neural Culture 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Antonia Vernadakis
    • 1
  1. 1.Departments of Psychiatry and PharmacologyUniversity of Colorado School of MedicineDenverUSA

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