Serotonin pp 445-453 | Cite as

Evidence for Neuronal Feedback Regulation of Serotonin Formation in Brain

  • Norton H. Neff
  • Leonard M. Neckers
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 133)


Over the last decade a body of evidence has accumulated to suggest that serotonergic neurons of brain are modulated, in part, by a negative neuronal feedback loop system (see Costa and Meek, 1974). Accordingly, neurons that contain serotonin receptors can modulate the information they receive from the serotonergic neurons either through axon collaterals from the receptive neurons directly to the serotonergic neurons or through interneurons to the serotonergic neurons (Fig. 1). A negative feedback loop serves to control, within narrow limits, neuronal impulse flow and thus information transfer from serotonergic neurons to receptive neurons. This type of process is highly efficient and is the basis for many control mechanisms currently used in the electronics industry.


Kainic Acid Dorsal Raphe Nucleus Serotonergic Neuron Tryptophan Hydroxylase Serotonin Synthesis 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Norton H. Neff
    • 1
  • Leonard M. Neckers
    • 2
  1. 1.Laboratory of Preclinical PharmacologyNational Institute of Mental Health, Saint Elizabeths HospitalUSA
  2. 2.Laboratory of Clinical PsychopharmacologyNational Institute of Mental Health, Saint Elizabeths HospitalUSA

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