Evidence for Neuronal Feedback Regulation of Serotonin Formation in Brain
Over the last decade a body of evidence has accumulated to suggest that serotonergic neurons of brain are modulated, in part, by a negative neuronal feedback loop system (see Costa and Meek, 1974). Accordingly, neurons that contain serotonin receptors can modulate the information they receive from the serotonergic neurons either through axon collaterals from the receptive neurons directly to the serotonergic neurons or through interneurons to the serotonergic neurons (Fig. 1). A negative feedback loop serves to control, within narrow limits, neuronal impulse flow and thus information transfer from serotonergic neurons to receptive neurons. This type of process is highly efficient and is the basis for many control mechanisms currently used in the electronics industry.
KeywordsKainic Acid Dorsal Raphe Nucleus Serotonergic Neuron Tryptophan Hydroxylase Serotonin Synthesis
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