Serotonin pp 391-416 | Cite as

Uptake and Metabolism of Serotonin and Amino Acids in Thiamine Deficiency

  • A. Plaitakis
  • W. J. Nicklas
  • M. H. Van Woert
  • E. Chung Hwang
  • S. Berl
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 133)


Thiamine deficiency (TD) in humans causes a well known clinical syndrome in which cerebellar ataxia, ophthalmoplegia and mental changes prevail (Wernicke’s encephalopathy). Some patients, who survive this acute encephalopathy, develop a characteristic chronic amnestic syndrome (Korsakoff’s psychosis). Experimental thiamine deficiency, produced acutely with thiamine analogs (pyrithiamine) or chronically with deficient diet, can result in neurological manifestations and brain pathologic changes resembling those seen in patients with Wernicke’s encephalopathy (Dreyfus, 1976). Therefore, such animal models have been used extensively to study the effects of TD in the nervous system.


Neurological Manifestation Thiamine Deficiency Serotonin Uptake Synaptosomal Preparation Serotonin Turnover 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • A. Plaitakis
    • 1
  • W. J. Nicklas
    • 1
  • M. H. Van Woert
    • 1
  • E. Chung Hwang
    • 1
  • S. Berl
    • 1
  1. 1.Departments of Neurology and PharmacologyMount Sinai School of MedicineNew YorkUSA

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