Serotonin pp 347-357 | Cite as

Brain Serotonin Receptors and Neuropsychiatric Disorders

  • S. J. Enna
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 133)


Numerous pharmacological, biochemical and physiological studies have indicated that alterations in the brain serotonin system may be present in various neuropsychiatric disorders (Chase, 1974). In the past, the biochemical evidence presented to support this hypothesis has been primarily related to the study of presynaptic markers or events. For example, using autopsy material, it has been reported that the concentration of this indoleamine is significantly reduced in the basal ganglia of Parkinson patients (Hornykiewicz, 1966). In addition, the cerebrospinal fluid content of 5-hydroxyin-doleacetic acid, the major metabolite of serotonin, has been found to be significantly reduced in Parkinson’s disease and torsion dystonia (Chase, 1974).


Receptor Binding Serotonin Receptor Neuropsychiatric Disorder Glutamic Acid Decarboxylase Neurotransmitter Receptor 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • S. J. Enna
    • 1
  1. 1.Departments of Pharmacology and of Neurobiology and AnatomyThe University of Texas Medical School at HoustonHoustonUSA

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