Brain Serotonin Receptors and Neuropsychiatric Disorders
Numerous pharmacological, biochemical and physiological studies have indicated that alterations in the brain serotonin system may be present in various neuropsychiatric disorders (Chase, 1974). In the past, the biochemical evidence presented to support this hypothesis has been primarily related to the study of presynaptic markers or events. For example, using autopsy material, it has been reported that the concentration of this indoleamine is significantly reduced in the basal ganglia of Parkinson patients (Hornykiewicz, 1966). In addition, the cerebrospinal fluid content of 5-hydroxyin-doleacetic acid, the major metabolite of serotonin, has been found to be significantly reduced in Parkinson’s disease and torsion dystonia (Chase, 1974).
KeywordsReceptor Binding Serotonin Receptor Neuropsychiatric Disorder Glutamic Acid Decarboxylase Neurotransmitter Receptor
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