Serotonin pp 37-49 | Cite as

Serotonin Binding Protein: Role in Transmitter Storage in Central and Peripheral Serotonergic Neurons

  • Michael D. Gershon
  • Hadassah Tamir
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 133)


Serotonin binding protein was first found in the brain in 1974 (Tamir and Huang, 1974). The regional distribution of SBP in the brain (Tamir and Kuhar, 1975) and spinal cord (Tamir and Gershon, 1979) was shown to parallel that of serotonin (5-HT). Since, in addition, the amount of SBP in the forebrain is decreased by lesioning the nuceli of the median raphe it seems likely that the protein is an intrinsic component of serotonergic neurons (Tamir and Kuhar, 1975). This conclusion is supported by the observation that SBP accumulates above, and decreases below, lesions of the spinal cord (Tamir and Gershon, 1979). Although SBP has only partially been purified, the unusually high affinity of the protein for 5-HT, the inhibition of 5-HT bindin by reserpine, and the characteristic dependence of SBP on Fe+2 for 5-HT binding enable SBP to be recognized (Tamir et al., 1976). The 5-HT-Fe+2-SBP complex has a mobility on 10% SDS-polyacrylamide gels corresponding to 60,000 daltons (figure 1).


Synaptic Vesicle Myenteric Plexus Serotonergic Neuron Spinal Cord Lesion Median Raphe 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Michael D. Gershon
    • 1
    • 2
  • Hadassah Tamir
    • 1
    • 2
  1. 1.Departments of Anatomy and PsychiatryColumbia University, College of Physicians and SurgeonsNew YorkUSA
  2. 2.Division of NeuroscienceNew York State Psychiatric InstituteNew YorkUSA

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