Influence of Histamine on Serotonin Metabolism in Rat Brain
Biogenic amines have long been known to be highly reactive substances which control many important biological functions. During the past few years progress has been made in the study of possible interaction between different amines, among them a relationship between histamine (HI) and serotonin (5HT) systems in mammals. Bevan et al. (1975) showed that noncontractile doses of HI can augment contractile responses of 5 HT in the isolated rabbit basilar artery; the results suggested direct or indirect interactions between H1 and 5HT receptors. Eyre et al. (1973) noted that the increase of plasma HI level in systemic calf anaphylaxis was antagonized by antiserotonin drugs, e.g. methysergide, but not by pyrilamine, a blocker of H1 histamine receptors. In our laboratory it was shown that HI-induced hypothermia in the rat was significantly reduced by both histamine H2-receptor and 5HT receptor antagonists, CIM and metergoline, respectively; by cyproheptadine, possessing anti-histamine H1-receptor and anti-5HT receptor activities, by PCPA, which impairs 5HT synthesis (Pilc and Nowak, 1979).
KeywordsBiogenic Amine Serotonin Metabolism Head Twitch Hypothalamic Slice Forepaw Treading
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