Serotonin pp 231-251 | Cite as

Regulatory Properties of Neuronal Tryptophan Hydroxylase

  • Michel Hamon
  • Sylvie Bourgoin
  • Françoise Artaud
  • David Nelson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 133)


Extensive studies for the past 10 years on the control of serotonin (5-HT) synthesis in central serotoninergic neurons have led to the conclusion that most regulatory mechanisms involve the first step of the biosynthetic pathway, i.e. tryptophan hydroxylation. This reaction is catalyzed by a highly specific enzyme, tryptophan hydroxylase (L-tryptophan-5-monooxygenase, EC, which is not saturated by tryptophan under physiological conditions. Thence, fluctuations in the concentration of this precursor amino-acid in the vicinity of the enzyme as well as changes in the intrinsic activity of tryptophan hydroxylase can both produce significant alterations in the rate of 5-HT synthesis in the central nervous system (CNS) (see Hamon and Glowinski, 1974 for review).


Tyrosine Hydroxylase Kainic Acid Tryptophan Hydroxylase Tryptophan Hydroxy Ferrous Ammonium Sulfate 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Michel Hamon
    • 1
  • Sylvie Bourgoin
    • 1
  • Françoise Artaud
    • 1
  • David Nelson
    • 1
  1. 1.Groupe NB, INSERM U.114Collège de FranceParis cedex 05France

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