Platelet Aggregation, Coagulation and Fibrinolysis at Rest and after Bicycle Ergometer Test in CHD

  • A. Strano
  • S. Novo
  • G. Davi’
  • G. Avellone
  • A. Pinto
Part of the Ettore Majorana International Science Series book series (EMISS, volume 4)


Several observers have suggested that a dysfunction of dynamic balance between platelet aggregation, coagulation and fibrinolysis may be a factor in the pathogenesis of atherosclerosis. This dysfunction, presumably, is correlated with the atherosclerotic vascular lesions, that could reduce the parietal synthesis of heparan-sulphase, prostacyclin and plas minogen activator.


Platelet Aggregation Angina Pectoris Stable Angina Fibrinolytic Activity Platelet Aggregate 
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  1. 1.
    G. V. R. Born, Quantitative investigation into the aggregation of platelets, J. Physiol, 20:423 (1965)Google Scholar
  2. 2.
    O. Carbonara, G. Mancini, Techniche di immunodiffusione per il dosaggio delle proteine, La Ricerca in Clin. e Lab. suppl. 1:151 (1970).Google Scholar
  3. 3.
    J. D. Cash, Effects of moderate exercise on the fibrinolytic system in normal young men and women, Br. Med. J. 2:502 (1966).PubMedCrossRefGoogle Scholar
  4. 4.
    F. D’Onofrio, L. Coppola, A. Tirelli, R. Russo, L. Misso, M. Varricchio, Comportamento dell’ aggregabilità piastrinica in soggetti normali e atero-arteriosclerotici dopo prova da sforzo al cicleorgometro, Atti Dell’ European Symposium on Coagulation, Fibrinolysis, Platelet aggregation and Atherosclerosis, p.395, ed. Ceop, Roma (1978).Google Scholar
  5. 5.
    J. Edy, F. de Coock, D. Collen, Inhibition of plasmin by normal and antiplasmin depleted plasma, Throm. Res. 8:513 (1976).CrossRefGoogle Scholar
  6. 6.
    A. Finkel, G. R. Cumming, Effects of exercise in the cold on blood clotting and platelets, J. Appl. Physiol, 5:549 (1970).Google Scholar
  7. 7.
    W. H. Frishman, B. Weksler, J. P. Christodoulou, C. Smithen, T. Killip, Reversal of a normal platelet aggregability and change in exercise tolerance in patients with angina pectoris following oral propanolol, Circ. 48:164 (1973).Google Scholar
  8. 8.
    J. W. Haerem, Sudden coronary death, the occurence of platelet aggregates in the epicardial arteries, Atherosclerosis 14:417 (1971).PubMedCrossRefGoogle Scholar
  9. 9.
    J. W. Haerem, Platelet aggregates in intramyocardial vessels of patients dying suddenly and unexpectedly of coronary artery disease, Atherosclerosis 15:199 (1972).PubMedCrossRefGoogle Scholar
  10. 10.
    J. W. Haerem. A role of platelet in the mechanism of myocardial infarction and sudden death, 7th European Congress of Cardiology Amsterdam (1976).Google Scholar
  11. 11.
    J. I. Haft, P. Kranz, F. Albert, K. Fani, Intravascular platelet aggregation in the heart induced by noreepinephrine; microscopic studies, Circ. 46:698 (1972).Google Scholar
  12. 12.
    J. I. Haft, K. Fani, Intravascular platelet aggregation in the heart induced by stress, Circ. 47:353 (1973).Google Scholar
  13. 13.
    J. I. Haft, K. Fani, Stress and the induction of intravascular platelet aggregation in the heart, Circ. 48:164 (1973).Google Scholar
  14. 14.
    S. G. Iatridis, J. H. Ferguson, Effect of physical exercise on blood clotting and fibrinolysis, J. Appl. Physiol. 18:353 (1973).Google Scholar
  15. 15.
    L. Jorgensen, H. C. Roswell, T. Hovig, M. F. Glynn, J. F. Mustard, Adenosine-diphosphate-induced platelet aggregation and myocardial infarction in Swine, Lab. Invest. 17:616 (1967).PubMedGoogle Scholar
  16. 16.
    R. Levites, J. I. Haft, Effects of exercise-induced stress on platelet aggregation, Cardiology 60:304 (1975).PubMedCrossRefGoogle Scholar
  17. 17.
    A. Maseri, Coronary vasospasm, coronary atherosclerosis and acute myocardial ischemia. A possible vicious cycle, Intern. Conf. on Ather., Milan, November 9–12 (1977).Google Scholar
  18. 18.
    S. Moncada, J. R. Vane, Arachidonic acid metabolites and interaction between platelets and blood-vessel walls, New Engl. J. Med. 1:1142 (1979).CrossRefGoogle Scholar
  19. 19.
    R. T. Moxley, F. Brackman, T. Astrup, Resting levels of fibrinolysis in blood in inactive and exercising men, J. Appl. Physiol. 5:549 (1970).Google Scholar
  20. 20.
    P. J. Nestle, Relationship between blood fibrinolytic activity, serum lipoproteins, and serum cholesterol in atherosclerotic arterial disease, Austr. Ann. Med. 9:234 (1960).Google Scholar
  21. 21.
    S. Novo, G. Avellone, F. d’Eredita, A. Pinto, Il tempo di lisi delle euglobuline. Nota I: Comportamento in un gruppo di soggetti giovani sani in relazione al peso corporeo relativo, Boll. Soc. It. Cardiol., XXI, 12:2145 (1976).Google Scholar
  22. 22.
    D. R. Redwood, D. R. Rosing, R. E. Goldstein, G. D. Beiser, S. E. Epstein, Importance of the design of an exercise protocol in the valuation of patients with angina pectoris, Circ. 43:618 (1971).Google Scholar
  23. 23.
    D. R. Rosing, P. Brakman, D. R. Redweed, R. E. Goldstein, G. D. Beiser, T. Astrup, S. E. Epstein, Blood fibrinolytic activity: diurnal variation and response to varying level of exercise, Circ. Res. 27:171 (1970).PubMedGoogle Scholar
  24. 24.
    D. R. Rosing, D. R. Redwood, P. Brakeman, Impairment of the diurnal fibrinolytic response in man — Effect of aging, type IV hyperliproteinemia, and coronary artery disease, Circ. Res. 32:752 (1973).PubMedGoogle Scholar
  25. 25.
    H. I. Russek, B. I. Zohman, Relative significance of heredity, diet and occupational stress in coronary heart disease of young adults: based on analysis of 100 patients between the ages of 25 and 40 years and a similar group of 100 normal subjects, Am. J. Med. Sci. 235:266 (1968).CrossRefGoogle Scholar
  26. 26.
    A. Strano. S. Novo, Prospettive sull’impiego degli antiaggreganti piastrinici nella prevenzione dell’aterosclerosi, Giorn. It. di Cardiol. IX, I, I, (1979).Google Scholar
  27. 27.
    K. N. Von Kaulla, Continous automatic recording of fibrin formation and fibrinolysis: a valuable method for coagulation research, J. Lab. Clin. Med. 49:304 (1957).Google Scholar
  28. 28.
    E. Von Kaulla, K. N. Von Kaulla, Antithrombin III and disease AM. J. Clin. Path. 48:69 (1967).Google Scholar
  29. 29.
    H. Yamazaki, T. Sano, T. Odakura, K. Takeuchi, T. Shimamoto, Electrocardiographic and hematological changes by exercise test in coronary patients and pyridinolcarbamate pretreatment. A double blind crossover trial, Am. Heart. J. 5:640 (1970).CrossRefGoogle Scholar
  30. 30.
    P. N. Walsh, Platelet coagulant activities and haemostasis: a hypothesis. Blood 43:597 (1974).PubMedGoogle Scholar
  31. 31.
    K. K. Wu, J. C. Hoak, A new method for the quantitative detection of platelet aggregates in patients with arterial insufficiency, Lancet 2:924 (1974).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • A. Strano
    • 1
  • S. Novo
    • 1
  • G. Davi’
    • 1
  • G. Avellone
    • 1
  • A. Pinto
    • 1
  1. 1.Clinica Medica IUniversity of PalermoItaly

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