Summary
Initial work on the fungus Neurospora crassa has shown that at least two DNA-repair systems exist in this eukaryote: excision repair and a mutation-prone repair. The evidence suggests that there is also a third repair system. Recently, new mutagen-sensitive strains have been isolated in several laboratories, but they are not yet fully characterized. A hunt for cytoplasmically inherited UV sensitivity has failed to turn up any such mutants among 25 new UV-sensitive isolates.
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References
Boyce, R. P., and P. Howard-Flanders, Release of ultraviolet light-induced thymine dimers from DNA in E. coli, Proc. Natl. Acad. Sci. (U.S.), 51 (1964) 293–300.
Chang, L. T., and R. W. Tuveson, Ultraviolet-sensitive mutants in Neurospora crassa, Genetics, 56 (1967) 801–810.
Chang, L. T., R. W. Tuveson, and M. H. Munroe, Non-nuclear inhertiance of UV sensitivity in Neurospora crassa, Can. J. Genet. Cytol., 10 (1968) 920–927.
Clark, A. J., and A. D. Margulies, Isolation and characterization of recombination-deficient mutants of Escherichia coli K-12, Proc. Natl. Acad. Sci. (U.S.), 53 (1965) 451–459.
Fincham, J. R. S., and P. R. Day, in: Fungal Genetics, 3rd ed., Botanical Monographs, Vol. 4, Blackwell Scientific, Oxford-Edinburgh, 1971, pp. 314, 320.
Fraser, M. J., S. Kwong, D. M. Galer, and T. Y.-K. Chow, Regulation by proteinases of a putative Rec − nuclease of Neurospora, in: DNA Repair Mechanisms, P. C. Hanawalt, E. C. Friedberg, and C. F. Fox, Eds., Academic Press, New York, 1978, pp. 441–444.
Fraser, M. G., Alkaline deoxyribonucleases released from Neurospora crassa mycelia: two activities not released by mutants with multiple sensitivities to mutagens, Nucl. Acids Res., 6 (1979) 231–246.
Fraser, M. J., T. Y.-K. Chow, and E. Käfer, Nucleases and their control in wild-type and nuh mutants of Neurospora, This volume, p. 63.
Howard-Flanders, P., and R. P. Boyce, DNA repair and genetic recombination: studies on mutants of Escherichia coli defective in these processes, Radiat. Res. (Suppl.), 6 (1966) 156–181.
Ishikawa, T., A. Toh-e, I. Unc, and K. Hasunuma, Isolation and characterization of nuclease mutants of Neurospora crassa, Genetics, 63 (1969) 75–95.
Joester, W., K.-E. Joester, B. van Dorp, and P. H. Hofschneider, Purification and properties of DNA-dependent DNA-polymerases from Neurospora crassa, Nucl. Acids Res., 5 (1978) 3043–3055.
Käfer, E., Sensitivity to methyl-methane-sulfonate in Neurospora, Neurospora Newsl., 25 (1978) 19.
Käfer, E., and M. Fraser, Isolation and genetic analysis of nuclease halo (nuh) mutants of Neurospora crassa, Mol. Gen. Genet., 169 (1979) 117–127.
Mehta, R. D., and J. Weijer, U.V. mutability in gamma-ray-sensitive mutants of Neurospora crassa, in: Symposium on Use of Radiation and Radioisotopes for Genetic Improvement of Industrial Microorganisms, International Atomic Energy Agency, Vienna, 1971, pp. 63–71.
Newmeyer, D., and D. R. Galeazzi, The instability of Neurospora duplication Dp(I1→IR) H4250 and its genetic control, Genetics, 85 (1977) 461–487.
Newmeyer, D., A. L. Schroeder, and D. R. Galeazzi, An apparent connection between histidine recombination and repair in Neurospora, Genetics, 89 (1978) 271–279.
Prakash, L., The relation between repair of DNA and radiation and chemical mutagenesis in Saccharomyces cerevisiae, Mutat. Res., 41 (1976) 241–248.
Raju, N. B., and D. D. Perkins, Barren perithecia in Neurospora crassa, Can. J. Genet. Cytol. 20 (1978) 54–59.
Schroeder, A. L., Ultraviolet-sensitive mutants of Neurospora, I. Genetic basis and effect on recombination, Mol. Gen. Genet., 107 (1970) 291–304.
Schroeder, A. L., Ultraviolet-sensitive mutants of Neurospora, II. Radiation studies, Mol. Gen. Genet., 107 (1970) 305–320.
Schroeder, A. L., Genetic control of radiation sensitivity and DNA repair in Neurospora, in: Molecular Mechanisms for Repair of DNA, P. C. Hanawalt and R. B. Setlow, Eds., Part B, Plenum Press, New York, 1975, pp. 567–576.
Schroeder, A. L., and S. L. Norton, unpublished data.
Setlow, R. B., and W. L. Carrier, The disappearance of thymine dimers from DNA: an error correcting mechanism, Proc. Natl. Acad. Sci. (U.S.), 51 (1964) 226–231.
Shelby, M. D., F. J. de Serres, and Gerald J. Stine, Ultraviolet-inactivation of conidia from heterokaryons of Neurospora crassa containing UV-sensitive mutations, Mutat. Res., 27 (1975) 45–58.
Stadler, D. R., and D. A. Smith, A new mutation in Neurospora for sensitivity to ultraviolet, Can. J. Genet. Cytol., 10 (1968) 916–919.
Tuveson, R. W., Genetic and enzymatic analysis of a gene controlling UV sensitivity in Neurospora crassa, Mutat. Res., 15 (1972) 411–424.
Weijer, J., and N. V. Vigfussion, Sexuality in Neurospora crassa, I. Mutations to male sterility, Genet. Res., 19 (1972) 191–204.
Worthy, T. E., and J. L. Epler, Biochemical basis of radiation sensitivity in mutants of Neurospora crassa, Mutat. Res., 19 (1973) 167–173.
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© 1980 Plenum Press, New York
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Schroeder, A.L., Olson, L.D. (1980). Mutagen-Sensitive Mutants in Neurospora. In: Generoso, W.M., Shelby, M.D., de Serres, F.J. (eds) DNA Repair and Mutagenesis in Eukaryotes. Basic Life Sciences, vol 15. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3842-0_4
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DOI: https://doi.org/10.1007/978-1-4684-3842-0_4
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