Repair and Mutation Induction in Mouse Germ Cells: A Summary and Some Thoughts
Evidence for repair of premutational lesions induced in mammalian germ cells has come from several directions, and some of it has been around for quite some time. Yet it is only as a result of relatively recent work that we now have the opportunity, with experimental mammals, to penetrate into areas of research that have already yielded rich rewards in yeast and Drosophila, namely, the genetics of repair capacity. This opportunity is particularly welcome in view of the fact that experimental mammals, which obviously could provide animal models for human genetic disease, have lagged behind man in the study of repair-deficiency states. Several such states are known in humans; in the mouse, we are only now on the threshold of discovering some.
KeywordsGerm Cell Repair Capacity Human Genetic Disease Radiation Dose Rate Early Spermatid
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