Relationship Between Repair Processes and Mutation Induction in Bacteria

  • R. F. Kimball
Part of the Basic Life Sciences book series (BLSC, volume 15)


A summary is given of the main repair and replication-associated processes that can influence the induction of mutations by various mutagens in bacteria. These include both constitutive and induced, error-free and error-prone systems. The mutation yield from a treatment with a mutagen can be markedly affected by which of these systems is operating in a given bacterial species or strain. The effect of these systems on mutation induction by ultraviolet light, monofunctional alkylating agents, base analogues, and frameshift mutagens is discussed in some detail. The bearing of these studies on the practical problems of estimating hazards is briefly considered.


Mismatch Repair Excision Repair Haemophilus Influenzae Mutation Induction Methyl Methanesulfonate 
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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • R. F. Kimball
    • 1
  1. 1.Biology DivisionOak Ridge National LaboratoryOak RidgeUSA

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