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Effect of Unilateral Deafferentation on the Development of the Lateral Geniculate Nucleus of the Dog

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Book cover Circulatory and Developmental Aspects of Brain Metabolism

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Abstract

Study of the morphological changes in the lateral geniculate nucleus (LGN) following bilateral deafferentation has been the subject of numerous studies (2, 8, 14, 15, 16, 17, 22, 23, 27). Fewer papers have dealt with unilateral deafferentation of the LGN by sectioning the optic tract and keeping the opposite side intact as a control (3, 6, 7, 35). The changes in the LGN after deafferentation are not only determined by the deafferentation procedures used but also by the age and species of the animals. When one eyelid is sutured in a young kitten, some of the geniculate cells, deprived of their normal visual input, grow to a lesser degree than normal (37, 38). The transneuronal cell atrophy that occurs in the dorsal LGN after removal of one eye is more rapid in young than in adult cats (12, 13, 21, 37, 38), and atrophic changes continue well beyond the time at which geniculate cell growth has stopped (14). The role of a binocular or translaminar competition in the production of the trans-neuronal atrophy has been emphasized only in very young animals (7, 14). In contrast, the comparative studies of the optic tract transection and eye enucleation, by Garey et al. (6, 7) suggested that even in adult cats there is some degree of cellular reaction present between the cells of the laminae. Total or partial deafferentation of the LGN in man (11) and monkeys (1, 31) produces severe degenerative changes with the disappearance of the nerve cells. In dogs and cats, the results obtained by various authors show considerable discrepancies. Klassovskij and Kosmarskaja (18) found in young dogs after a bilateral enucleation a disappearance of most cell elements in the LGN, while Figurina (4) performing the same operation found a slight loss of the cells, only in the proximal parts of that nucleus.

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Authors and Affiliations

  1. Brain Research Laboratory, Institute for Biological and Medical Research of Montenegro, Kotor, Yugoslavia

    Lidija Lazarević, Lj. M. Rakić & N. N. Lyubimov

  2. Brain Institute, Academy of Medical Sciences, Moscow, USSR

    Lidija Lazarević, Lj. M. Rakić & N. N. Lyubimov

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  1. Lidija Lazarević
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  2. Lj. M. Rakić
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  3. N. N. Lyubimov
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Editors and Affiliations

  1. U.S. Department of Health, Education, and Welfare Laboratory of Neuropathology and Neuroanatomical Sciences, N.I.N.C.D.S., N.I.H., Bethesda, Maryland, USA

    Maria Spatz

  2. University of Belgrade, Belgrade, Yugoslavia

    B. B. Mršulja  & Lj. M. Rakić  & 

  3. Laboratory of Neurochemistry, N.I.N.C.D.S., N.I.H., Bethesda, Maryland, USA

    W. D. Lust

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© 1980 Plenum Press, New York

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Lazarević, L., Rakić, L.M., Lyubimov, N.N. (1980). Effect of Unilateral Deafferentation on the Development of the Lateral Geniculate Nucleus of the Dog. In: Spatz, M., Mršulja, B.B., Rakić, L.M., Lust, W.D. (eds) Circulatory and Developmental Aspects of Brain Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3836-9_29

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  • DOI: https://doi.org/10.1007/978-1-4684-3836-9_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3838-3

  • Online ISBN: 978-1-4684-3836-9

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