Effects of Convulsions on Rabbit Hippocampal Gangliosides during Hippocampus Development

  • D. Kostić
  • A. Vranešević


Brain tissue of animal species with lower as well as higher degree of biological organization contains large amounts of gangliosides. The distribution and the characteristics of these complex substances were studied in the whole brain of rats and other animals as well as in specific human brain regions during brain development (1, 4, 10, 22). Investigations concerned with the subcellular localization of sialic acid-containing compounds in the brain indicated that the synaptosomes and in particular the synaptosomal plasma membranes were rich in gangliosides (2, 34). High concentrations of tri-tetra- and pentasialogangliosides were observed in the central nervous regions which are important in electrogenesis of the electric fish (T. ocellate) (12, 16). The content of sialic acid was found to be changed during the excitation of the brain (9). It was shown also that the exposure to light caused an increase in synaptosomal and a decrease in mitochondrial ganglio-sides in the rat brain (17). However, Dreyfus observed that the biosynthesis of ganglioside was greater during the adaptation to light than to darkness in the chick retina (5). Thus, these substances may be involved in the transmission process.


Sialic Acid Status Epilepticus Electric Fish Synaptic Plasma Membrane Total Ganglioside 
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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • D. Kostić
    • 1
  • A. Vranešević
    • 1
  1. 1.Laboratory for Neurochemistry Institute of Biochemistry Faculty of MedicineUniversity of BelgradeYugoslavia

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