Neuronal-Glial Interactions during Neural Growth in Culture
Although there exists a vast body of information concerning brain maturation, we know relatively very little about neuronal-glial interrelationships during neural growth and differentiation. In view of the fact that glial cells in the central nervous system (CNS) outnumber neurons by a factor of ten, their role in CNS function continues to be the subject of much investigation. Glial cells have been proposed to be involved in myelination (3) to act as spatial ionic buffers (10), to be electrically coupled to neurons (23), and to proliferate with increased neuronal activity (4, 11). More recently we (22), and others (6), have proposed that glial cells may also modulate neuronal activity by regulating the amount of neurotransmitter substances in the microenvironment. In this paper we will review and discuss responses of glial cells to hormones and glial cell-hormone-neurotransmitter interrelationship.
KeywordsGlial Cell Chick Embryo Cerebral Hemisphere Central Nervous System Function Neural Growth
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