Changes of the Soluble and Insoluble Glycoprotein Glycans during Rat Brain Development

  • C. Di Benedetta
  • P. Corsi
  • G. Gennarini
  • F. Vitiello


The high complexity of the nervous tissue structures, which underlines the complexity of the brain function, requires that proper connections are made during the nervous system organizational stage. The formation of neural circuitry is, therefore, an important step in order to equip the brain with a correct and adequate substrate for its function.


High Molecular Weight Proper Connection Adequate Substrate Soluble Glycoprotein Polysaccharide Moiety 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Barondes, S.H. and Rosen, S.D. (1976): Cell surface carbohydrate-binding proteins: role in cell recognition. In: Neuronal Recognition. S.H. Barondes (ed), pp. 331 - 356, Chapman and Hall, London.CrossRefGoogle Scholar
  2. 2.
    Bosmann, H.B., Hagopian, A. and Eylar, E.H. (1969): Cellular membranes: the biosynthesis of glycoprotein and glycolipid in Hela cell membranes. Arch. Biochem. Biophys. 130: 573-583.Google Scholar
  3. 3.
    Brunngraber, E.G. (1969): The possible role of glycoproteins in neural function. Perspect. Biol. and Med. 12 (3): 467 - 470.Google Scholar
  4. 4.
    Corsi, P., Gennarini, G., Vitiello, F. and Di Benedetta, C. (1979): Apparent half life time of soluble fucosylglycoproteins during brain development. In: A Multidisciplinary Approach to Brain Development. C. Di Benedetta, R. Balazs, G. Gombos, G. Porcellati (eds.), Elsevier, North Holland, Amsterdam, in pressGoogle Scholar
  5. 5.
    Di Benedetta, C. (1974): Structural and functional significance of brain glycoproteins. In: Central Nervous System, Studies on Metabolic Regulation and Function. E. Genazzini and H. Herken, (eds.). pp. 33 - 40, Springer-Verlag, Berlin, New York.Google Scholar
  6. 6.
    Di Benedetta, C., Brunngraber, E.G., Whitney, G.,Brown, D.B. and Aro, A. (1969): Compositional patterns of sialofucohexosaminoglycans derived from rat brain glycoproteins. Arch. Biochem. Biophys. 131: 404-413.Google Scholar
  7. 7.
    Di Benedetta, C., Chang, I. and Brunngraber, E.G. (1971): Electrophoretic separation and properties of soluble glycoproteins extracted from whole rat brain tissue. Ital. J. Biochem. 20: 49-65.Google Scholar
  8. 8.
    Di Benedetta, C. and Cioffi, L.A. (1972): Glycoproteins during the development of the rat brain Adv. Exp. Med. Biol. 25: 115-124.Google Scholar
  9. 9.
    Di Benedetta, C. and Cioffi, L.A. (1972): Early malnutrition, brain glycoproteins and behavior in rats. Bibliotheca Nutritio et Dieta, 17: 69 - 82.PubMedGoogle Scholar
  10. 10.
    Di Benedetta, C., Corsi, P., Gennarini, G. and Vitiello, F. (1979): Developmental pattern of brain glycoproteins. In: A Multidisciplinary Approach to Brain Development. C. Di Benedetta, R. Balazs, G. Gombos and G. Porcellati (eds.), Elsevier North Holland, Amsterdam, in press.Google Scholar
  11. 11.
    Di Benedetta, C., De Luca, B. and Cioffi, L.A. (1970): Rat brain proteins and glycoproteins during development. Protides Biol. Fluids, 18: 181 - 184.Google Scholar
  12. 12.
    Dische, Z. (1966): The informational potentials of conjugated proteins. Protides Biol. Fluids 13: 1-20.Google Scholar
  13. 13.
    Dutton, G.R. and Barondes, S.H. (1970): Glycoprotein metabolism in developing mouse brain. J. Neurochem. 17: 913 - 920.PubMedCrossRefGoogle Scholar
  14. 14.
    Gennarini, G., Iannelli, D., Corsi, P. and Di Benedetta, C. (1978): Immunochemical relationship between cytosol and synaptosomal glycoproteins of rat brain. Proc. ESN, 1: 607.Google Scholar
  15. 15.
    Gombos, G., Vincendon, G., Reeber, A., Ghandour, M.S. and Zanetta, J.P. (1978): Membrane glycoproteins in synaptogenesis. Proc. ESN, 1: 174-188.Google Scholar
  16. 16.
    Holian, O., Dill, D. and Brunngraber, E.G. (1971): IncorporWon of radioactivity of D-glucosamine-I- C into heteropolysaccaride chains of glycoproteins in adult and developing rat brain. Arch. Biochem. Biophys. 142: 111-121.Google Scholar
  17. 17.
    Krusius, T., Finne, J., Kärkkäinen, J. and Järnefelt, J. (1974): Neutral and acidic glycopeptides in adult and developing rat brain. Biochim. Biophys. Acta 365: 80-92.Google Scholar
  18. 18.
    Margolis, R.K. and Gomez, Z. (1973): Rapid turnover of fucose in the water-soluble glycoproteins of brain. Biochim. Biophys. Acta 313: 226-228.Google Scholar
  19. 19.
    Margolis, R.K. and Gomez, Z. (1974): Structural changes in brain glycoproteins during development. Brain Res. 74: 370 - 372.PubMedCrossRefGoogle Scholar
  20. 20.
    Margolis, R.K., Preti, C. and Margolis, R.U. (1976): Developmental changes in brain glycoproteins. Brain Res. 112: 363 - 369.PubMedCrossRefGoogle Scholar
  21. 21.
    Moscona, A.A. (1976): Cell recognition in embryonic morphogenesis and the problem of neuronal specificities. In: Neuronal Recognition. S.H. Barondes (ed.) pp. 205 - 226, Chapman and Hall, London.CrossRefGoogle Scholar
  22. 22.
    Quarles, R.H. and Brady, 0. (1971): Synthesis of glycoproteins and gangliosides in developing rat brain. J. Neurochem. 18: 1809 - 1820.PubMedCrossRefGoogle Scholar
  23. 23.
    Truding, R., Shelanski, M.L., Daniels, M.P. and Morell, P. (1974): Comparison of surface membranes isolated from cultured murine neuroblastoma cells in the differentiated or undifferentiated state. J. Biol. Chem. 249: 3973-3982.PubMedGoogle Scholar
  24. 24.
    Van Nieuw Amerongen, A. and Roukema, P.A. (1975): The appearance of the soluble and the membrane-bound fractions of the nervous tissue-specific sialoglycoprotein GP-350 in the developing rat brain. Brain Res. 89: 358 - 362.CrossRefGoogle Scholar
  25. 25.
    Zanetta, J.P., Breckenridge, W.C. and Vincendon, G. (1972): Analysis of monosaccharides by gasliquid chromatography of the 0-methyl-glycosides as trifluoroacetate derivatives. Application to glycoproteins and glycolipids. J. Chromatogr. 69: 291-304.Google Scholar
  26. 26.
    Zanetta, J.P., Roussel, G., Ghandour, M.S., Vincendon, G. and Gombos, G. (1978): Postnatal development of rat cerebellum: massive and transient accumulation of concanavalin A binding glycoproteins in parallel fiber axolemma. Brain Res. 142: 301 - 319.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • C. Di Benedetta
    • 1
  • P. Corsi
    • 1
  • G. Gennarini
    • 1
  • F. Vitiello
    • 1
  1. 1.Istituto di Fisiologia UmanaUniversità di BariItaly

Personalised recommendations