Abstract
The turnover rates of brain rRNAs were measured in male and female Wistar rats during the postnatal (7–31 days) and “adolescent” (38–58 days) periods in either the whole hemispheres or in the various substructures. These rates were considerably accelerated during the postnatal development, with T/2 values being reduced by 50 percent or more in the adult rats (26) when compared to the younger group. A difference in rRNA replacement rates was observed throughout the postnatal life between males and females. It was moderately significant in the younger group and highly significant in adolescents and young adults. These differences were also demonstrable in most of the studied cerebral substructures. The growth-correlated and sex-linked differences found are discussed in terms of RNA conservation as related to growth rate, the evolving male and female sexual steroid patterns, and the possible sexual dimorphism unrelated to sex hormones.
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References
Balazs, R., Kovacs, S., Cocks, W.A., Johnson, A.L. and Eayrs, J.T. (1971): Effect of thyroid hormone on the biochemical maturation of rat brain: postnatal cell formation. Brain Res. 25: 555–570.
Balazs, R. and Richter, D. (1973): Effects of hormones on the biochemical maturation of the brain. Chapter 7. In: Biochemistry of the Developing Brain, Vol. 1, W. Himwich (ed.), pp. 253–299, Marcel Dekker, Inc., New York.
Berthold, W. and Lim, L. (1976): Nucleo-cytoplasmic relationships of high-molecular-weight ribonucleic acid, including polyadenylated species, in the developing rat brain. Biochem. J. 154: 529–539.
Borota, J.S. and Petrovic, S.L. (1979): Differences in turnover rates of ribosomal RNA in the kidney of female mice in hypertrophy induced by uninephrectomy and by androgen treatment. Iug. Phys. Pharm. Acta, in press.
Buchanan, D.L. (1961): Total carbon turnover measured by feeding a uniformly labeled diet. Arch. biochem. biophys. 94: 500–511.
Crowley, W.R., O’Donohue, T.L. and Jacobowitz, D.M. (1978): Sex differences in catecholamine content in discrete brain nuclei of the rat: effects of neonatal castration or testosterone treatment. Acta endocrinol. 89: 20–28.
Dellweg, H., Gerner, R. and Wacker, A. (1968): Quantitative and qualitative changes in ribonucleic acids of rat brain dependent on age and training experiments. J. Neurochem. 15: 1109–1119.
Donaldson, H.H. and Hatai, S. (1931): On the weight of the parts of the brain and on the percentage of water in them according to brain weight and to age, in albino and in wild Norway rats. J. Comp. Neurol. 53: 263–307.
Fraser, R.S.S. and Nurse, P. (1979): Altered patterns of ribonucleic acid synthesis during the cell cycle: a mechanism compensating for variation in gene concentration. J. Cell Sci. 35: 25–40.
Henningson, S., Persson, L. and Rosengren, E. (1979): Polyamine metabolism in the kidneys of castrated and testosterone-treated mice after administration of methylglyoxal-bis/guanylhydraxone/. Biochim. biophys. acta 582: 448–457.
Hill, J.M. and Malamud, D. (1974): Decreased protein catabolism during stimulated growth. FEBS Letters 46: 308–311.
Himwich, H.E. (1973): Early studies of the developing brain. Chapter 1. In: Biochemistry of the Developing Brain, Vol. 1, W. Himwich (ed.), pp. 1–53, Marcel Dekker, Inc., New York.
Hirsch, C.A. and Hiatt, H.H. (1966): Turnover of liver ribosomes in fed and in fasted rats. J. Biol. Chem. 241: 5936–5940.
Howard, E. (1973): DNA content of rodent brains during maturation and aging, and autoradiography of postnatal DNA synthesis in monkey brain. Progr. Brain Res. 40: 91–114.
Howard, E. (1974): Hormonal effects on the growth and DNA content of the developing brain. Chapter 8. In: Biochemistry of the Developing Brain, Vol. 2, W. Himwich (ed.), pp. 1–68, Marcel Dekker, Inc., New York.
Von Hungen, K., Mahler, H.R. and Moore, W.J. (1968): Turnover of protein and ribonucleic acid in synaptic subcellular structures from rat brain. J. Biol. Chem. 243: 1415–1423.
Jacobson, M. (1978): Developmental Neurobiology, 2nd edition. Plenum Press, New York.
Johnson, T.C. (1967): The effects of maturation on in vitro RNA synthesis by mouse brain cells. J. Neurochem. 14: 1075–1081.
De Jong, F.H. and Sharpe, R.M. (1977): The onset and establishment of spermatogenesis in rats in relation to gonadotrophin and testosterone levels. J. Endocrinol. 75: 197–207.
Koenig, G., Goldstone, A. and Hughes, C. (1978): Lysosomal enzymuria in the testosterone-treated mouse. A manifestation of cell defecation of residual bodies. Lab. Invest. 39: 329–341.
Kolodny, G.M. (1975): Turnover of ribosomal RNA in moust fibroblasts (3T3) in culture. Exp. Cell Res. 91: 101–106.
Lajtha, A., Latzkovits, L. and Toth, J. (1976): Comparison of turnover rates of proteins of the brain, liver and kidney in mouse in vivo following long term labeling. Biochim. biophys. acta 425: 511–520.
Menzies, R.A. and Gold, P.H. (1972): The apparent turnover of mitochondrial ribosomes and sRNA of the brain in young adult and aged rats. J. Neurochem. 19: 1671–1683.
Miller, D.A., Breg, W.R., Warburton, D., Dev, V.G. and Miller, O.J. (1978): Regulation of rRNA gene expression in a human familial 14p+ marker chromosome. Hum. Genet. 43: 289–297.
Morrow, A.G., Carroll, D.M. and Greenspan, E.M. (1951): A sex difference in the kidney glucuronidase activity of inbred mice. J. Natl. Cancer Inst. 11: 663–669.
Novakovic, B.B., Petrovic, S.L., Rakic, L.M. and Ivanus, J.J. (1979): Different turnover rates of brain ribosomal ribonucleic acids in male and female rats. J. Neurochem. 33: 661–667.
Novakovic, M.B., Rakid, L.M. and Petrovid, S.L. Manuscript in preparation.
Paigen, K. (1961): The genetic control of enzyme activity during differentiation. Proc. Nat. Acad. Sci. USA 47: 1641–1649.
Petrovid, S.L., Novakovid, M.B., Tepavac, R.I. and Wilson, C.W. (1977): Androgen-induced accretion of ribonucleic acids in kidney of female mouse (Mus musculus). Int. J. Biochem. 8: 193–198.
Petrovid, S.L., Borota, J.S., Novakovid, M.B. and Marinkovid, D.V. (1979): Coordinacy in the induction of acid glycosidases by testosterone in mice. Proc. Special FEBS Meeting on Enzymes, Dubrovnik, P. Mildner (ed.), Pergamon, London, in press.
Scott, J.F. (1977): Turnover of ribosomal RNA in cells in culture. Exp. Cell Res. 108: 207–219.
Seiler, N. and Schmidt-Glenewinkel, T. (1975): Regional distribution of putrescine, spermidine and spermine in relation to the distribution of RNA and DNA in the rat nervous system. J. Neurochem. 24: 791–795.
Slob, A.K., Ooms, M.P. and Vreeburg, J.T.M. (1978): Sex ratio in utero and the plasma concentration of testosterone in male and female rat foetuses. J. Endocrinol. 79: 395–396.
Snedecor, G. and Cochrane, W. (1968): Statistical Methods. Sixth edition. University of Iowa Press, Ames, Iowa.
Swank, R.T., Davey, R., Joyce, L., Reid, P. and Macey, M.R. (1977): Differential effects of hypophysectomy on the synthesis of beta-glucuronidase and other androgen-inducible enzymes in mouse kidney. Endocrinology 100: 473–480.
Tantravahi, R., Miller, D.A., D’Ancona, G., Croce, C.M. and Miller, O.J. (1979): Location of rRNA genes in three inbred strains of rat and suppression of rat rRNA activity in rat-human somatic cell hybrids. Exp. Cell Res. 119: 387–392.
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Petrović, S.L., Novaković, M.B., Rakić, L.M., Ivanuš, J.J., Tepavac, R.I., Berner, A.I. (1980). General and Regional Turnover of Ribosomal Ribonucleic Acids in the Brain of Male and Female Rats during Postnatal Development. In: Spatz, M., Mršulja, B.B., Rakić, L.M., Lust, W.D. (eds) Circulatory and Developmental Aspects of Brain Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3836-9_22
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DOI: https://doi.org/10.1007/978-1-4684-3836-9_22
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