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Studies on the Blood-Brain Barrier (BBB) to Monoamines

  • T. Abe
  • K. Abe
  • D. Mićić
  • B. M. Djuričić
  • B. B. Mršulja
  • M. Spatz

Abstract

Cerebral ischemia leads to a postischemic modification of the blood-brain barrier (BBB) permeability to substances which under normal conditions do not easily cross the BBB. The BBB change appeared to be selective since the leakage of various molecules tested was related to their size and/or their specific transport system (2, 12, 13). A distinct alteration of BBB permeability has also been observed for the monoamines (4). The enhanced passage of 5-hydroxytryptamine (5-HT) occurred prior to that of norepinephrine (NE) in gerbils subjected to bilateral common carotid artery occlusion and release (2).

Keywords

Monoamine Oxidase Bilateral Common Carotid Artery Occlusion COMT Activity Monoamine Oxidase Activity Cerebral Microvessels 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • T. Abe
    • 1
    • 2
  • K. Abe
    • 1
    • 2
  • D. Mićić
    • 1
    • 2
  • B. M. Djuričić
    • 1
    • 2
  • B. B. Mršulja
    • 1
    • 2
  • M. Spatz
    • 1
    • 2
  1. 1.Laboratory of Neuropathology and Neuroanatomical Sciences National Institute of Neurological and Communicative Disorders and StrokeNational Institutes of HealthBethesdaUSA
  2. 2.Laboratory for Neurochemistry Institute of BiochemistryFaculty of MedicineBelgradeYugoslavia

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