Intravascular Aggregation of Platelets and Cerebrovascular Insufficiency
Platelet aggregation undoubtedly plays a major role in the pathogenesis of many types of ischemic cerebrovascular disease. When platelet aggregates occlude a vessel’s lumen, the vasoactive substances released from platelets, such as 5-hydroxytryptamine (serotonin), histamine and prostaglandin endoperoxide, may play a role in the genesis of the ischemic disease. Among these substances, prostaglandin endoperoxide and thromboxane A2 have recently drawn attention, because of their ability to contract the vessels and aggregate platelets. These prostaglandins (PGs) are produced from the arachidonic acid that probably originates from phospholipids in the platelet’s membrane.
KeywordsCarotid Artery Arachidonic Acid Evans Blue Vasoactive Substance Lingual Artery
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