Intravascular Aggregation of Platelets and Cerebrovascular Insufficiency

  • Tsukasa Fujimoto
  • Yutaka Inaba
  • Takeshi Motomiya
  • Hiroh Yamazaki


Platelet aggregation undoubtedly plays a major role in the pathogenesis of many types of ischemic cerebrovascular disease. When platelet aggregates occlude a vessel’s lumen, the vasoactive substances released from platelets, such as 5-hydroxytryptamine (serotonin), histamine and prostaglandin endoperoxide, may play a role in the genesis of the ischemic disease. Among these substances, prostaglandin endoperoxide and thromboxane A2 have recently drawn attention, because of their ability to contract the vessels and aggregate platelets. These prostaglandins (PGs) are produced from the arachidonic acid that probably originates from phospholipids in the platelet’s membrane.


Carotid Artery Arachidonic Acid Evans Blue Vasoactive Substance Lingual Artery 
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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Tsukasa Fujimoto
    • 1
    • 2
  • Yutaka Inaba
    • 1
    • 2
  • Takeshi Motomiya
    • 1
    • 2
  • Hiroh Yamazaki
    • 1
    • 2
  1. 1.Department of NeurosurgeryTokyo Medical and Dental UniversityTokyoJapan
  2. 2.Division of Cardiovascular ResearchTokyo Metropolitan Institute of Medical ScienceTokyoJapan

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