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Intravascular Aggregation of Platelets and Cerebrovascular Insufficiency

  • Tsukasa Fujimoto
  • Yutaka Inaba
  • Takeshi Motomiya
  • Hiroh Yamazaki

Abstract

Platelet aggregation undoubtedly plays a major role in the pathogenesis of many types of ischemic cerebrovascular disease. When platelet aggregates occlude a vessel’s lumen, the vasoactive substances released from platelets, such as 5-hydroxytryptamine (serotonin), histamine and prostaglandin endoperoxide, may play a role in the genesis of the ischemic disease. Among these substances, prostaglandin endoperoxide and thromboxane A2 have recently drawn attention, because of their ability to contract the vessels and aggregate platelets. These prostaglandins (PGs) are produced from the arachidonic acid that probably originates from phospholipids in the platelet’s membrane.

Keywords

Carotid Artery Arachidonic Acid Evans Blue Vasoactive Substance Lingual Artery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Caen, J.P., Cronberg, S. and Kubisz, P. (1977): Physiology and Pathology, Stratton, p. 16, Intercontinental Medical Book Corp., New York.Google Scholar
  2. 2.
    Ellis, E.F., Nies, A.S. and Oates, J.A. (1977): Cerebral arterial smooth muscle contraction by thromboxane A2. Stroke 8: 480–483.PubMedCrossRefGoogle Scholar
  3. 3.
    Ellis, E.F., Oels, O., Roberts, L.J., Payne, N.A., Sweetman, B.J., Nies, A.S. and Oates, J.A. (1976): Coronary arterial smooth muscle contraction by a substance released from platelets, evidence that it is thromboxane A2. Science 193: 1135–1137.PubMedCrossRefGoogle Scholar
  4. 4.
    Furlow, T.W. and Bass, N.H. (1975): Fatty acids, platelets, and microcirculatory obstruction. Science 190: 491.Google Scholar
  5. 5.
    Furlow, T.W. and Bass, N.H. (1975): Stroke in rats produced by carotid injection of sodium arachidonate. Science 187: 658–660.PubMedCrossRefGoogle Scholar
  6. 6.
    Furlow, T.W. and Bass, N.H. (1976): Arachidonateinduced cerebrovascular occlusion in the rat. Neurology 26: 297–304.PubMedGoogle Scholar
  7. 7.
    Hamberg, M., Svensson, J. and Samuelsson, B. (1975): Thromboxanes, a new group of biologically active compounds derived from prostaglandin endoperoxides. Proc. Natl. Acad. Sci. USA 72: 2994–2998.Google Scholar
  8. 8.
    Ramberg, M., Svensson, J., Wakabayashi, T. and Samuelsson, B. (1974): Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation. Proc. Natl. Acad. Sci. USA 71: 345–349.Google Scholar
  9. 9.
    Haslam, R.J. (1964): Role of adenosine diphosphate in the aggregation of human blood platelets by thrombin and by fatty acids. Nature 202: 765–768.PubMedCrossRefGoogle Scholar
  10. 10.
    Hovig, T. (1963): Release of a platelet aggregation substance (adenosine diphosphate) from rabbit blood induced by saline “extract” of tendon. Thrombi. Diath. Haemorrh. 9: 264–278.Google Scholar
  11. 11.
    Majno, G., Shea, S.M. and Leventhal, M. (1969): Endothelial constriction induced by histamine-type mediators. An electronmicroscopic study. J. Cell. Biol. 42: 647.Google Scholar
  12. 12.
    Motomiya, T., Matsubara, O. and Yamazaki, H. (in press): Constriction and damage of the pulmonary artery by suddenly induced intravascular aggregation of platelets. Cardiovascul. Surgery.Google Scholar
  13. 13.
    Mustard, J.F. and Packham, M.A. (1975): The role of blood and platelets in atherosclerosis and the complication of atherosclerosis. Thromb. Diath. Haemorrh. 33: 444–456.Google Scholar
  14. 14.
    Silver, M.J., Hoch, W. and Kocsis, J.J. (1974): Arachidonic acid causes sudden death in rabbits. Science 183: 1085–1087.PubMedCrossRefGoogle Scholar
  15. 15.
    Smith, J.B. and Willis, A.L. (1970): Formation and release of prostaglandins by platelets in response to thrombin. Br. J. Pharmacol. 40: 545.Google Scholar
  16. 16.
    Spector, A.A. and Hoak, J.C. (1975): Fatty acids, platelets and microcircirculatory obstruction. Science 190: 490–491.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Tsukasa Fujimoto
    • 1
    • 2
  • Yutaka Inaba
    • 1
    • 2
  • Takeshi Motomiya
    • 1
    • 2
  • Hiroh Yamazaki
    • 1
    • 2
  1. 1.Department of NeurosurgeryTokyo Medical and Dental UniversityTokyoJapan
  2. 2.Division of Cardiovascular ResearchTokyo Metropolitan Institute of Medical ScienceTokyoJapan

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