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The Effect of Chemically and Electrically Induced Acute Hypertension on the Permeability Across Cerebral Vessels

  • Erik Westergaard

Abstract

The term, blood-brain barrier (BBB), was introduced by Ehrlich (7) who observed that intravenously injected dyes stained all of the animals’ organs except their brains. Likewise, it was observed that trypan blue did not pass the BBB (6) and the intravenously injected fluorescein behaved similarly (16, 24). These chemical compounds bind to albumin in the blood (28). The cerebral microvasculature therefore constitutes a barrier to dye-albumin complexes. However, it cannot be excluded that very small amounts in fact could have passed the barrier in these experiments since the sensitivity of the methods employed is limited.

Keywords

Tight Junction Systemic Blood Pressure Acute Hypertension Endothelial Plasma Membrane Cerebral Arteriole 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Erik Westergaard
    • 1
  1. 1.Anatomy Department CUniversity of CopenhagenCopenhagenDenmark

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