Mechanisms of Ischemic Brain Damage in Acute Arterial Hypertension

  • I. V. Gannushkina
  • M. V. Baranchikova


During the last 8–10 years, it has been shown that the breakdown of the cerebral blood flow autoregulation is the main reason for the damage of the cerebral vessels and brain tissue in acute arterial hypertension (2, 7, 9, 13, 17, 19). Consequently, the passive dilatation of the superficial arteries of brain increases the permeability of the blood-brain barrier (BBB) to all the constituents of blood including blood proteins (i.e., filtration edema develops). The spotty distribution of the damages among the normal unchanged brain structures is characteristic for all the processes studied: brain blood supply and filling changes in the pial arteriolar caliber, BBB permeability to the Evans blue-bound proteins, accumulation of proteins in astrocytes and neurons as well as the parenchymatous spread of the tracer (1–3, 7, 10, 14).


White Matter Mean Arterial Blood Pressure Evans Blue Blue Spot Ischemic Brain Damage 
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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • I. V. Gannushkina
    • 1
  • M. V. Baranchikova
    • 1
  1. 1.Institute of NeurologyAcademy of Medical ScienceMoscowUSSR

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