Specific Inhibitors of Androgen Binding to the Androgen-Binding Protein (ABP)

  • Jacques I. Quivy
  • Raymond Devis
  • Xuan-Hoa Bui
  • Jean-Pierre Schmit
  • Guy G. Rousseau
Part of the Biochemical Endocrinology book series (BIOEND)


Androgen-binding protein (ABP) is a protein produced by the rat testis. It is distinct from the intracellular androgen receptor present in target tissues (Table I). Following binding of testosterone secreted by the Leydig cells on luteinizing hormone stimulation, ABP reaches, via the seminiferous tubules, the epididymis, beyond which it disappears (French and Ritzén, 1973; Hansson et al., 1974). It has been suggested that ABP serves as an androgen-concentrating factor (Hansson et al., 1973; Purvis and Hansson, 1978) that may be essential for sperm maturation in the epididymis. Indirect evidence points to the role of ABP in spermatogenesis and sperm maturation: the supportive effect of follicle-stimulating hormone (FSH) on these processes is mediated by the Sertoli cells (Fakunding et al., 1976), the only known source of ABP is the Sertolicell (Hagenäs et al., 1975), ABP synthesis is induced by FSH (Hansson et al., 1973; Fakunding et al., 1976), appearance of ABP at puberty coincides with onset of fertility (Hansson et al., 1973), and disappearance of ABP after 100 days of age in Hre mutants coincides with onset of sterility (Musto and Bardin, 1976).


Androgen Receptor Sertoli Cell Seminiferous Tubule Cyproterone Acetate Sperm Maturation 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Jacques I. Quivy
    • 1
    • 2
  • Raymond Devis
    • 2
  • Xuan-Hoa Bui
    • 2
  • Jean-Pierre Schmit
    • 3
  • Guy G. Rousseau
    • 1
  1. 1.International Institute of Molecular and Cellular PathologyBrusselsBelgium
  2. 2.Unité de Chimie Hormonologique et de PharmacognosieUniversité de LouvainBrusselsBelgium
  3. 3.Département de ChimieUniversité de SherbrookeSherbrooke (Québec)Canada

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