Fertility and Antifertility Effects of LH-RH and Its Agonists

  • U. K. Banik
  • M. L. Givner
Part of the Biochemical Endocrinology book series (BIOEND)


Following isolation, purification (Schally et al., 1971; Amoss et al., 1971), and elucidation of the chemical structure of luteinizing-hormone-releasing hormone (LH-RH) (Matsuo et al., 1971a; Burgus et al., 1971) and its synthesis (Matsuo et al., 1971b; Monahan et al., 1971), many investigators (see White et al., 1973; Immer et al., 1974) synthesized a number of analogues that are more potent than LH-RH in releasing LH and follicle-stimulating hormone (FSH) and inducing ovulation in animals and humans (Fugino et al., 1974; Schally et al., 1976; Keye et al., 1976).


Mating Behavior Medroxyprogesterone Acetate Luteinizing Hormone Release Hormone Ethynyl Estradiol Rhythm Method 


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  1. Amoss, M., Burgus, R., Blackwell, R., Vale, W., Fellows, R., and Guillemin, R., 1971, Purification, amino acid composition and N-terminus of the hypothalamic luteinizing hormone releasing factor (LRF) of ovine origin, Biochem. Biop/zys. Res. Commun. 44:205.Google Scholar
  2. Banik, U.K., and Givner, M.L., 1975, Ovulation induction and antifertility effects of an LH-RH analogue (AY-25,205) in cyclic rats, J. Reprod. Ferri!. 44:87.CrossRefGoogle Scholar
  3. Banik, U.K., and Givner, M.L., 1976a, Induction of ovulation in adult mice with aGoogle Scholar
  4. synthetic LH-RH (AY-24,031) and an analogue (AY-25,205), J. Reprod. Ferri!. 47:95. Banik, U.K., and Givner, M.L., 19766, Effects of luteinizing hormone-releasing hormone analogue on mating and fertility in rats, Ferti!. Steril. 27:1078.Google Scholar
  5. Banik, U.K., and Givner, M.L., 1977, Comparative ovulation-inducing capacity of a synthetic luteinizing hormone-releasing hormone and two analogs in adult rats and mice, Fertil. Steril. 28:1243.Google Scholar
  6. Banik, U.K., and Herr, F., 1969, Effects of medroxyprogesterone acetate and chlorpromazine on ovulation and vaginal cytology in a strain of 4-day cyclic rats, Can. J. Physiol. Pharmacol. 47:573.CrossRefGoogle Scholar
  7. Banik, U.K., Revesz, C., and Herr, F., 1969, Orally active oestrogens and progestins in prevention of pregnancy in rats, J. Reprod. Fenil. 18:509.CrossRefGoogle Scholar
  8. Barraclough, C.A., 1966, Modification in the CNS regulation of reproduction after exposure of prepubertal rats to steroid hormones, Recent Prog. Horm. Res. 22: 503.Google Scholar
  9. Bergquist, C., Nillius, S.J. and Wide, L., 1979, Inhibition of ovulation in women by intranasal treatment with a luteinizing hormone-releasing hormone agonist, Contraception 19:497.Google Scholar
  10. Burgus, R., Butcher, M., Ling, N., Monahan, M., Rivier, J., Fellows, R., Amoss, M.,Blackwell, R., Vale, W., and Guillemin, R., 1971, Structure moléculaire du fracteur hypotrape hypophysaire du luteinisation (LH), C. R. Acad. Sc. (Paris) 273:1611.Google Scholar
  11. Casper, R.F., and Yen, S.C., 1979, Induction of luteolysis in the human with a long-acting analog of luteinizing hormone releasing factor, Science 205:408.Google Scholar
  12. Clark, J.H., and Zarrow, M.X., 1971, The influence of copulation on time of ovulation in women, Am. J. Obstet. Gynecol. 109: 1083.Google Scholar
  13. Corbin, A., Beattie, C.W., Tracy, J., Jones, R., Foelie, T.J., Yardley, J., and Rees, R.W.A., 1978, The anti-reproductive pharmacology of LH-RH and agonistic analogues, Int. J. Ferti!. 23:81.Google Scholar
  14. Cusan, L., Auclair, C., Bélanger, A., Ferland, L., Kelly, P.A., Seguin, C., and Labrie, F., 1979, Inhibitory effects of long term treatment with a luteinizing hormone-releasing hormone agonist on the pituitary—gonadal axis in male and female rats, Endocrinology 104: 1369.CrossRefGoogle Scholar
  15. Diczfalusy, E., 1968, Mode of action of contraceptive drugs, Am. J. Obstet. Gynecol. 10:163.Google Scholar
  16. Everett, J.W., and Sawyer, C.H., 1950, A 24-hour periodicity in the “LH-release apparatus” of female rats, disclosed by barbiturate sedation, Endocrinology 47:198.CrossRefGoogle Scholar
  17. Fugino, M., Fukuda, T., Shinagawa, S., Kobayashi, S., Yamazaki, I., Nakayama, R., Seely, J.H., White, W.F., and Rippe!, F.H., 1974, Synthetic analogs of luteinizing hormone-releasing hormone (LH-RH) substituted in position 6 and 10, Biochem. Biophys. Res. Commun. 60:406.CrossRefGoogle Scholar
  18. Gay, V.L., 1972, The hypothalamus: Physiology and clinical use of releasing factors, Ferti!. Steril. 23:50.Google Scholar
  19. Guillemin, R., 1972, Physiology and chemistry of the hypothalamic relasing factors for gonadrotropins: A new approach to fertility control, Contraception 5:1.Google Scholar
  20. Hertig, A.H., 1967, The overall problem in man, in: Comparative Aspects of Reproductive Failure (K. Benirschke, ed.), pp. 11–41, Springer-Verlag, New York, Heidelberg, and London.CrossRefGoogle Scholar
  21. Hilgers, T.W., Abraham, G.E., and Cavanagh, D., 1978, Natural family planning. 1. The peak symptom and estimated time of ovulation, Obstet. Gynecol. 52:575.Google Scholar
  22. Humphrey, R.R., Windsor, B.L., Bausley, F.G., and Edgren, R.A., 1976, Antifertility effects of an analog of luteinizing hormone releasing hormone (LH-RH) in rats, Contraception 14: 625.CrossRefGoogle Scholar
  23. Humphrey, R.R., Windsor, B.L., Jones, D.L., Reel, J.R., and Edgren, R.A., 1978, The effects of luteinizing hormone releasing hormone (LH-RH) in pregnant rats. 2. Prenidatory effects and delayed parturition, Biol. Reprod. 19:84.CrossRefGoogle Scholar
  24. Immer, H., Nelson, V.R., Revesz, C., Sestanj, K., and Gotz, M., 1974, Luteinizing hormone-releasing hormone and analogs: Synthesis and biological activity, J. Med. Chem. 17: 1060.CrossRefGoogle Scholar
  25. Jöchle, W., 1973, Coitus-induced ovulation, Contraception 7: 523.CrossRefGoogle Scholar
  26. Johnson, F.S., Seely, J.H., White, W.F., and de Sombre, E.F., 1976, Endocrine dependent rat mammary tumor regression: Use of gonadotropin releasing hormone analog, Science 194: 329.CrossRefGoogle Scholar
  27. Keye, W.R., Jr., Young, F.R., and Jaffe, R.B., 1976, Hypothalamic gonadotrop in releasingGoogle Scholar
  28. hormone: Physiologic and clinical considerations, Obstet. Gynecol. Surv. 31: 635.Google Scholar
  29. Knaus, H., 1930, Die periodische Frucht-und Unfruchtbarkeit des Weibes, Zentralbi. Gynaekol. 57: 1393.Google Scholar
  30. Lee, P.A., Jaffe, R.B., and Midgley, A.R., 1974, Lack of alteration of serum gonadotropins in men and women following sexual intercourse, Am. J. Obstet. Gynecol. 120: 985.Google Scholar
  31. Lemay, A., Labrie, F., Ferland, L., and Raynaud, J.P., 1979, Possible luteolytic effects of luteinizing hormone-releasing hormone in normal women, Fertil. Steril. 31: 29.Google Scholar
  32. Macdonald, G.J., and Beattie, C.W., 1979, Pregnancy failure in hypophysectomized rats following LH-RH administration, Life Sci.24:1103.Google Scholar
  33. Mastroianni, L., 1974, Rhythm: Systematized chance-taking, Fam. Plann. Perspect. 6: 209.CrossRefGoogle Scholar
  34. Matsuo, H., Baba, Y., Nair, R.M.G., Arimura, A., and Schally, A.V., 197la, Structure of the porcine LH- and FSH-releasing hormone. 1. The proposed amino acid sequence,Biochem. Biophys. Res. Commun. 43:1334.Google Scholar
  35. Matsuo, H., Arimura, A., Nair, R.M.G., and Schally, A.V., 1971b, Synthesis of the porcine LH- and FSH-releasing hormone by the solid phase method, Biochem. Biophys. Res. Commun. 45: 822.CrossRefGoogle Scholar
  36. Mayer, M.Q., Tarnaysky, G.K., and Reeves, J.J., 1977, Ovarian growth and uptake of iodinated D-Leu“-des-Gly-NH210-LH-RH ethylamide in HCG treated prepuberal rat, Proc. West. Sect. Am. Soc. Anim. Sci. 28: 182.Google Scholar
  37. Monahan, M., Rivier, J., Burgus, R., Amoss, M., Blackwell, R., Vale, W., and Guillemin, R., 1971, Synthesis totale par phase solide d’un decapeptide qui stimule la sécretion des gonadotrophines hypophysaires LH et FSH, C. R. Acad. Sci. (Paris) 273: 508.Google Scholar
  38. Morishita, H., Mitani, H., Masuda, Y., Higuchi, K., Tomioka, M., Nagamachi, N., Kawamoto, M., Ozasa, T., and Adachi, H., 1974, Effect of synthetic luteinizing hormone releasing hormone on ovulation during the oestrus cycle in the rat, Acta Endocrino!. (Copenhagen) 76: 431.Google Scholar
  39. Moss, R.L., and McCann, S.M., 1973, Induction of mating behavior in rats by luteinizing hormone-releasing factor, Science 181: 177.CrossRefGoogle Scholar
  40. Ogino, K., 1930, Ovulationstermin und Konzeptionstermin, Zentrabl. Gynaekol.54: 464.Google Scholar
  41. Pfaff, D., 1973, Luteinizing hormone-releasing factor potentiates lordosis behavior in hypophysectomized ovariectomized female rats, Science 182: 1148.CrossRefGoogle Scholar
  42. Ross, C., and Piotrow, P.T., 1974, Periodic abstinence, Population Reports, Series I, Number 1, Population Information Program, The John Hopkins University, Baltimore, Maryland.Google Scholar
  43. Schally, A.V., Arimura, A., Baba, Y., Nair, R.M.G., Matsuo, H., Redding, T.W., Debeljuk, L., and White, W.F., 1971, Isolation and properties of the FSH and LH-releasing hormone, Biochem. Biopys. Res. Commun. 43: 393.CrossRefGoogle Scholar
  44. Schally, A.V., Arimura, A., Kastin, A.J., Matsuo, H., Baba, Y., Redding, T.W., Nair,R.M.G., Debeljuk, L., and White, W.F., 1973, Gonadotropin-releasing hormone: One polypeptide regulates secretion of luteinizing and follicle stimulating hormones, Science 173: 1036.Google Scholar
  45. Schally, A.V., Kastin, A.J., and Coy, D.H. 1976, LH-releasing hormone and its analogs: Recent basic and clinical investigations, Int. J. Fertil. 21:1.Google Scholar
  46. Stearns, E.L., Winter, J.S.D., and Faiman, C., 1973, Effects of coitus on gonadotropin, prolactin and sex steroid levels in men, J. Clin. Endocrinol. 37: 687.CrossRefGoogle Scholar
  47. White, W.F., Hedlund, M.T., Rippel, R.H., Arnold, W., and Flouret, G.R., 1973, Chemical and biological properties of gonadotropin-releasing hormone synthesized by the solid-phase method, Endocrinology 93: 96.CrossRefGoogle Scholar
  48. Wilson, J.R., Alader, N., and Boeuf, B.L., 1965, The effects of intromission frequency on successful pregnancy in the female rat, Proc. Natl. Acad. Sci. U.S.A. 53:1392 53:1392.Google Scholar
  49. Yamazaki, I., Nakagawa, H., and Yoshida, K., 1978, Induction of ovulation by luteinizing hormone-releasing hormone (LH-RH) and its analogues in rats under various preovulatory sexual conditions, Endocrinol. Jpn. 25: 503.CrossRefGoogle Scholar
  50. Zarrow, M.X., Campbell, P.S., and Clark, J.H., 1968, Pregnancy following coital-induced ovulation in a spontaneous ovulator, Science 159: 329.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • U. K. Banik
    • 1
  • M. L. Givner
    • 1
  1. 1.Department of Endocrinology and ImmunochemistryAyerst Research LaboratoriesMontrealCanada

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