Induction of Menstruation Following Subcutaneous Injection of LH-RH and Intranasal Administration of [D-Ser(TBU)6 des-Gly-NH210]LH-RH Ethylamide after Ovulation in Normal Women

  • A. Lemay
  • F. Labrie
  • J. P. Raynaud
Part of the Biochemical Endocrinology book series (BIOEND)


Although luteinizing-hormone-releasing hormone (LH-RH) can induce ovulation in the animal (Schally and Arimura, 1977) and in some cases in the human (Nillius, 1976), it has recently been demonstrated that this hypothalamic hormone, as well as potent agonistic analogues, have antifertility effects in the animal. The administration of LH-RH or its agonistic analogue [D-Ala6,des-Gly-NH2 10] LH-RH ethylamide on diestrus I or II in normal female rats has been shown to delay the expected day of mating and vaginal cornification (Banik and Givner, 1975; Beattie and Corbin, 1977; Ferland et al.,1978; Kledzik et al.,1978a). Gonado-tropin-releasing peptides also have potent postcoital contraceptive activity in female rats (Corbin et al.,1976; Humphrey et al.,1976; Kledzik et al., 1978b) and rabbits (Hilliard et al., 1976).


Luteal Phase Intranasal Administration Serum Progesterone Serum Progesterone Level Posttreatment Cycle 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • A. Lemay
    • 1
  • F. Labrie
    • 2
  • J. P. Raynaud
    • 3
  1. 1.Laboratory of Endocrinology of Reproduction, Department of Obstetrics and GynecologyHôpital St. François D’AssiseQuebecCanada
  2. 2.Department of Molecular EndocrinologyLe Centre Hospitalier de l’Université LavalQuebecCanada
  3. 3.Centre de Recherches Roussel-UclafRomainvilleFrance

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