Skip to main content

Role of Prostaglandins in Leydig-Cell Stimulation by hCG and Leydig-Cell Function

  • Chapter
Reproductive Processes and Contraception

Part of the book series: Biochemical Endocrinology ((BIOEND))

Abstract

In many different cell types, prostaglandins have the ability to modify hormone action (Shio et al., 1971), an effect known to be correlated with changes in cyclic AMP (cAMP) levels. In the restricted case of steroid-producing cells, as found in ovarian and testicular tissues, numerous data indicate that prostaglandins are directly involved in the mechanism of luteinizing hormone (LH)-human chorionic gondadotropin (hCG) action and in post-cAMP events (Phariss and Behrman, 1973; Kuehl et al., 1970; Kuehl, 1974; Cenedella, 1975; Samuelson et al., 1978).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bartke, A., Musto, N., Caldwell, B.V., and Behrman, H.R., 1973, Effects of a cholesterol inhibitor and of prostaglandin F2α on testis cholesterol and on plasma testosterone in mice, Prostaglandins 3: 97.

    Article  CAS  Google Scholar 

  • Bartke, A., Kupfer, D., and S. Dalterio, 1976, Prostaglandins inhibit testosterone secretion by mouse testes in vitro, Steroids 28: 81.

    Article  CAS  Google Scholar 

  • Behrman, H.R., and Hickens, M., 1976, Rapid measurement of gonadotropin uptake by corpora lutea in vivo induced by prostaglandins F2α, Prostaglandins 12: 83.

    Article  CAS  Google Scholar 

  • Behrman, H.R., MacDonald, G.J., and Greep, R.O., 1971, Regulation of ovarian cholesterol esters: Evidence for the enzymatic sites of prostaglandin-induced loss of corpus luteum function, Lipids 6: 791.

    Article  CAS  Google Scholar 

  • Bockaert, J., Hunzicker-Dunn, M., Biznbaumer, L., 1976, Hormone stimulation of hormone dependent adenylate cyclase. Dual action of luteinizing hormone on pig Graafian follicle membranes, J. Biol. Chem 251: 2653.

    CAS  Google Scholar 

  • Carpenter, M.P., 1974, Prostaglandins of rat testis, Lipids 9: 397.

    Article  CAS  Google Scholar 

  • Carpenter, M.P., Manning, L.M., Robinson, R.D., and To, D., 1978, Prostaglandin synthesis by interstitial tissue of rat testis, Prostaglandins 15: 711.

    Article  Google Scholar 

  • Cenedella, R.J., 1975, Prostaglandins and male reproduction physiology, in:Advances in Sex Hormone Research, Vol. 1, Molecular Mechanism of Gonadal Hormone Action (J.A. Thomas and R.L. Singhal, eds.), pp.327–360, University Pati. Press, Baltimore.

    Google Scholar 

  • Chasalow, F., and Pharriss, B:B., 1972, Luteinizing hormone stimulation ofov rian prostaglandin biosynthesis, Proaragiaidifie 1: 105.

    Google Scholar 

  • Chasalow, F., Marr,H., Haour, F., and SwsrJ,M., 1979, Testicular steroidogenesis after hCG desensitization in rats, J. Biol. Chem. 254:5613.

    CAS  Google Scholar 

  • Clark, M.R.,Marsh, J.M., and Lemaire, W.J., 1978a, Stimulation of prostaglandin accumulation in preovulatory rat follicles by adenosine 3´,5´-monophosphate, Endocrinology 102:39.

    Article  CAS  Google Scholar 

  • Clark, M.R., Marsh,J.M., and Le Maire, W.J., 1978a,b, Mechanism of luteinizing hormone regulation of prostaglandin synthesis in rat granulosa cells, J. Biol. Chem. 253:7757.

    CAS  Google Scholar 

  • Cooke, B.A., Rommerts; F.F.G.,van der Kemp, J.W.C.M., and van der Molen, H.J., 1974, Effects of luteinizing hormone, follicle stimulating hormone, prostaglandin E1 and other hormones on adenosine-3’:5’-cyclic monophosphate and testosterone production in rats testis tissues, Mol. Cell Endocrinol. 1:99.

    Article  CAS  Google Scholar 

  • Dazord, A., Morera, A.M., Bertrand, J., and Saez, J.M., 1974, Prostaglandin receptors in human and ovine adrenal glands: Binding and stimulation of adenyl cyclase in subcellular fractions, Endocrinology 95:352.

    Article  Google Scholar 

  • Dray, F., Charbonnel, B., and Maclouf, J., 1975, Radioimmunoassay of prostaglandins F2α, E1 and F2 in human plasma, Eur. J. Clin. Invest. 5: 311.

    Google Scholar 

  • Dray, F.,Charbonnel, B., and Maclouf, J., 1976, Primary prostaglandins in human peripheral plasma by radioimmunoasssy, in: Advances in Prostaglandin and Thromboxane Research, Vol. 1 (B. Samuelson and R. Paoletti, eds.), p. 93, Raven Press, New York.

    Google Scholar 

  • Eik-Nes, K.B., 1969, Pattern of steroidogenesis in the vertebrate gonad, Gen. Comp. Edocrinol. Suppl. 2:87.

    Article  Google Scholar 

  • Ellis, L.C., Johnson, J.M., and Hargrove, J.L., 1972, Cellular aspect of prostaglandin synthesis and testicular functions, in: Prostaglandins in Cellular Biology (P.W. Ramwell and B.P. Phariss, eds.), p. 385, Plenum Press, New York.

    Google Scholar 

  • Gerozissis, K., and Dray, F., 1977a, Prostaglandins in the isolated testicular capsule of immature and young adult rats, Prostaglandins 13:177.

    Google Scholar 

  • Gerozissis, K., and Dray, F., 1977b, Selective and age dependent changes of prostaglandins E2 in the epididymis and vas deferens of the rat, J. Reprod. Fertil. 50: 113.

    Article  CAS  Google Scholar 

  • Grinwich, D.L., Hichens, M., and Behrman, H.R., 1976, Control of the LH receptor by prolactin and prostaglandin F2α in rat corpora lutea, Biol. Reprod. 14:212.

    Article  CAS  Google Scholar 

  • Grotjan, H.E., Heindel, J.S., and Steinberger, E., 1978, Prostaglandin inhibition of testosterone production induced by luteinizing hormone, DbcAMP or 3-isobutyl-1methylxanthine in dispersed rat testicular interstitial cells, Steroids 32:307.

    Article  CAS  Google Scholar 

  • Haour, F., and Saez, J.M., 1977, hCG-dependent regulation of gonadotropin receptor sites: Negative control in testicular Leydig cells, Mol, Cell Endocrinol.7: 17.

    Article  CAS  Google Scholar 

  • Haour, F., and Saez, J.M., 1978, Leydig cell responsiveness to LH—hCG stimulation: Mechanisms of hCG and steroid induced refractoriness, in: Structure and Function of the Gonadotropins (K.W. McKerns, ed.), pp. 497–516, Plenum Press, New York.

    Google Scholar 

  • Haour, F., Sanchez, P., Cathiard, A.M., and Saez, J.M., 1978, Gonadotropin receptor regulation in hypophysectomized rat Leydig cells, Biochem.Biophys. Res. Commun. 81:547.

    Article  CAS  Google Scholar 

  • Haour, F., Kouznetzova, B., Dray, F., and Saez, J.M., 1979, hCG-induced prostaglandin E. and F2 release in adult rat testis: Role in Leydig cells desensitization to hCG, Life Sci. 24:2151.

    Article  CAS  Google Scholar 

  • Haye, B., and Jacquemin, C., 1977, Incorporation of 14C arachidonate in pig thyroid lipids and prostaglandins, Biochim. Biophys. Acta 687: 231.

    Google Scholar 

  • Honn, K.J., and Chavin, W., 1976, Prostaglandin modulation of the mechanism of ACTH action in the human adrenal,Biochem. Biophys. Res. Commun. 73:164.

    Article  CAS  Google Scholar 

  • Hsueh, A.J.W., Dufau, M.L., and Catt, K.J., 1977, Gonadotropin induced regulation of luteinizing hormone receptors and desensitization of testicular 3´5´-cAMP and testosterone response, Proc. Natl. Acad. Sci. U.S.A. 74: 592.

    Article  CAS  Google Scholar 

  • Kimball, F.A., Frielink, R.D., and Porteus, S.E., 1978, Effect of 15 (S)-15 methylprostag- landin F2α methyl ester containing Silastic discs in male rats, Fertil. Steril. 29: 103.

    CAS  Google Scholar 

  • Kuehl, F.A., Jr., Humes, J.L., Tarnoff, J., Cirillo, C.J., and Ham, E.A., 1970, Prostaglandin receptor site: Evidence for an essential role in the action of luteinizing hormone, Science 169: 883.

    Article  CAS  Google Scholar 

  • Kuehl, F.A., Jr., 1974, Prostaglandins, cyclic nucleotides and cell function, Prostaglandins 5: 325.

    Article  CAS  Google Scholar 

  • Lamprecht, S.A., Zor, U., Solomon, Y., Kock, Y., Ahren, K., and Lindner, H.R., 1977, Mechanism of hormonally induced refractoriness of ovarian adenylate cyclase in luteinizing hormone and prostaglandin E2, J. Cyclic Nucleotide Res. 3: 69.

    CAS  Google Scholar 

  • Lapetina, E.G., Schmitges, C.J., Chandrabose, K., and Cuatrecasas, P., 1977, Cyclic adenosine 3´5´-monophosphate and prostacyclin inhibit membrane phospholipase activity in platelets, Biochem. Biophys. Res. Commun. 76: 828.

    Article  CAS  Google Scholar 

  • Laychock, S.G., Warner, W., and Rubin, R.P., 1977, Further studies on the mechanism controlling prostaglandin biosynthesis in the cat adrenal cortex: Role of calcium and cAMP, Endocrinology 100: 74.

    Article  CAS  Google Scholar 

  • Malmsten, C., Granström, E., And Samuelson, B., 1976, Cyclic AMP inhibits synthesis of prostaglandin endoperoxide (PGG2) in human platelets, Biochem. Biophys. Res. Commun. 68: 569.

    Article  CAS  Google Scholar 

  • Marsh, J.M., Yang, N.S.T., and Lemaire, W.J., 1974, Prostaglandin synthesis in rabbit Graafian follicle in vitro: Effect of luteinizing hormone and cyclic AMP, Prostaglandins 7:269.

    Google Scholar 

  • Marsh, J.M., and Le Maire, W.J., 1974, Cyclic AMP accumulation and steroidogenesis in the human corpus luteum: Effect of gonadotropins and prostaglandins, J. Clin. Endocrinol. Metab. 38: 99.

    Article  CAS  Google Scholar 

  • Mather, J., and Sato, G.H., 1978, Hormones and growth factors in cell cultures: Problems and perspectives, in: Cell Tissue and Organ Cultures in Neurobiology ( S. Federoff and L. Hertz, eds.), pp. 619–630, Academic Press, New York.

    Google Scholar 

  • Mather, J.P., and Sato, G.H., 1979, Use of hormone-supplemented serum-free media in primary culture, Exp. Cell Res. 124: 215.

    Article  CAS  Google Scholar 

  • Mather, J.P., Saez, J.M., and Haour, F., 1980, Life Sci. (submitted).

    Google Scholar 

  • McNatty, K.P., Henderson, K.M., and Sawers, R.S., 1975, Effects of prostaglandin F2α and E2 on the production of progesterone by human granulosa cells in tissue culture, J. Endocrinol. 67: 231.

    Article  CAS  Google Scholar 

  • Peyrat, J.P., Meusy-Dessolle, N., and Gamier, J., 1980, Properties of luteinizing hormone receptors in porcine testis: Variations with age and interstitial tissue development, Endocrinology (submitted).

    Google Scholar 

  • Phariss, B.B., and Behrman, H.R., 1973, in: Gonadal Function in the Prostaglandins, Vol. 1 (P.W. Ramwell, ed.), pp. 347–363, Plenum Press, New York.

    Google Scholar 

  • Rao, C.V., 1976, Discrete prostaglandin receptors in the outer cell membrane of bovine corpora lutea, in: Advances in Prostaglandin and Thromboxane Research, Vol. 1 ( B. Samuelson and R. Paoletti, eds.), p. 267, Raven Press, New York.

    Google Scholar 

  • Saez, J.M., Haour, F., Gallet, D., and Sanchez, P., 1978a, hCG-induced Leydig cells refractoriness to gonadotropin stimulation, Mol. Pharmacol.14: 1054.

    CAS  Google Scholar 

  • Saez, J.M., Haour, F., and Cathiard, A.M., 1978b, Early hCG-induced desensitization in Leydig cells, Biochem. Biophys, Res. Commun. 81: 552.

    CAS  Google Scholar 

  • Saksena, S.K., Lan, I.F., and Chang, M.C., 1978, Effect of intrascrotal implants of prostaglandins E2 or F2α on blood steroids in the adult male rat, Int. J. Androl. 1: 180.

    Google Scholar 

  • Samuelson, B., Goldyne, M., Granstrom, E., Hamberg, M., Hammaastrom, S., and Malmsten, C., 1978, Prostaglandins and thromboxane, Annu. Rev. Biochem. 47: 997.

    Article  Google Scholar 

  • Sharpe, R.M., 1976, hCG-induced decrease in availability of rat testis receptors, Nature (London) 264: 644.

    Article  CAS  Google Scholar 

  • Shio, H., Shaw, J., and Ramwell, P., 1971, Relation of cyclic AMP to the release and action of prostaglandins, Ann. N. Y. Acad. Sci.185: 326.

    Article  Google Scholar 

  • Tell, G.P., Haour, F., and Saez, J.M., 1978, Hormonal regulation of membrane receptors and cell responsiveness: A review, Metabolism 27: 1566.

    Article  CAS  Google Scholar 

  • Thomas, J.P., Dorflinger, L.J., and Behrman, H.R., 1978, Mechanism of the rapid antigonadotropic action of prostsaglandins in cultured luteal cells, proc. Natl. Acad. Sci. U.S.A. 75: 1344.

    Article  CAS  Google Scholar 

  • Zor, U., Strulovici, B., and Lindner, H.R., 1977a, Stimulation by cyclic AMP of prostaglandin E production in isolated Graafian follicles, Biochem. Biophys. Res. Commun. 76: 1086.

    Article  CAS  Google Scholar 

  • Zor, U., Strulovici, B., and Lindner, H.R., 1977b, Stimulation by cyclic nucleotides of prostaglandin E production in isolated Graafian follicles, Prostaglandins 14: 947.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Plenum Press, New York

About this chapter

Cite this chapter

Haour, F., Mather, J., Bizzini-Kouznetzova, B., Dray, F. (1981). Role of Prostaglandins in Leydig-Cell Stimulation by hCG and Leydig-Cell Function. In: McKerns, K.W. (eds) Reproductive Processes and Contraception. Biochemical Endocrinology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3824-6_31

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-3824-6_31

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3826-0

  • Online ISBN: 978-1-4684-3824-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics