Porcine and Human Ovarian Nonsteroidal Follicular Regulators

Oocyte-Maturation Inhibitor, Luteinization Inhibitor, Luteinizing-Hormone-Receptor-Binding Inhibitor, Follicle-Stimulating-Hormone-Binding Inhibitor, and Inhibin F
  • Cornelia P. Channing
  • L. D. Anderson
  • Sarah Lipford Stone
  • Satish Batta
Part of the Biochemical Endocrinology book series (BIOEND)


The ovarian follicle and the oocyte mature at a well-controlled rate in response to a constant as well as to changing levels of pituitary gonad­otropins. In the primate, only one follicle grows to maturity and ovulates an ovum each menstrual cycle, while at least 200 other follicles undergo atresia (for reviews, see Greenwald, 1978; Byskov, 1978). The mechanism for choice of one follicle over the other is not known. Since all follicles are exposed to the same level of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (Sakai and Channing, 1979a,ó), local ovarian factors rather than systemic hormones should be responsible for choice of follicle. Local factors controlling follicular maturation include steroids as well as nonsteroidal factors. The local steroids primarily secreted by the ovary are: (1) estrogen, which stimulates granulosa-cell growth (Bradbury, 1961; Rao et al., 1978; Harman et al., 1975; (2) androgen, which may play a role in atresia in the rat (Louvet et al., 1975), since administration of testosterone antiserum diminishes follicular atresia in the rat; and (3) progesterone, which may partially regulate the initiation of new follicular growth, since DeZerga and Hodgen (1979), personal communication) found that the insertion of Silastic wafers impregnated with progesterone into the ovary immediately after removal of its corpus luteum can lead to a delay in follicular growth.


Luteinizing Hormone Granulosa Cell Corpus Luteum Follicular Fluid Oocyte Maturation 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Cornelia P. Channing
    • 1
  • L. D. Anderson
    • 1
  • Sarah Lipford Stone
    • 1
  • Satish Batta
    • 2
  1. 1.Department of Physi­ologyUniversity of Maryland School of MedicineBaltimoreUSA
  2. 2.Department of AnatomyUniversity of Maryland School of MedicineBaltimoreUSA

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