Uterine Diamine Oxidase
The classic bioassays for progesterone and biologically active progestins are tedious and semiquantitative. These assays and their limitations were described recently (Glasser, 1975). The synthesis of RNA was suggested by Glasser (1975) to be a reasonably specific and reproducible quantitative biochemical endpoint for the action of progestins on the uterus. Another biochemical endpoint, the synthesis of uteroglobin (UTG), has been used by Jänne et al. (1978) as a measure of the progestin activity of natural and synthetic androgens. While there was good correlation between biological activity (induction of UTG synthesis) and binding affinity to the rabbit uterine progesterone receptor, the UTG bioassay is expensive to use routinely for the evaluation of a large number of compounds.
KeywordsMedroxyprogesterone Acetate Diamine Oxidase Testosterone Propionate Decidual Tissue Synthetic Androgen
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