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Uterine Diamine Oxidase

A Marker for Progestin Action
  • C. H. Spilman
  • D. C. Beuving
  • K. K. Bergstrom
Part of the Biochemical Endocrinology book series (BIOEND)

Abstract

The classic bioassays for progesterone and biologically active progestins are tedious and semiquantitative. These assays and their limitations were described recently (Glasser, 1975). The synthesis of RNA was suggested by Glasser (1975) to be a reasonably specific and reproducible quantitative biochemical endpoint for the action of progestins on the uterus. Another biochemical endpoint, the synthesis of uteroglobin (UTG), has been used by Jänne et al. (1978) as a measure of the progestin activity of natural and synthetic androgens. While there was good correlation between biological activity (induction of UTG synthesis) and binding affinity to the rabbit uterine progesterone receptor, the UTG bioassay is expensive to use routinely for the evaluation of a large number of compounds.

Keywords

Medroxyprogesterone Acetate Diamine Oxidase Testosterone Propionate Decidual Tissue Synthetic Androgen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • C. H. Spilman
    • 1
  • D. C. Beuving
    • 1
  • K. K. Bergstrom
    • 1
  1. 1.Fertility ResearchThe Upjohn CompanyKalamazooUSA

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