Gonadotropic Stimulation of Enzymes Involved in Testicular Growth

  • Claude A. Villee
  • Janet M. Loring
Part of the Biochemical Endocrinology book series (BIOEND)

Abstract

The marked decrease in testicular size following hypophysectomy and its restoration toward normal following the injection of pituitary extracts have long been known. Analyses of the endocrine and molecular mechanisms involved in the growth response of the gonads to gonadotropins have been undertaken by many investigators. Gonadotropic hormones increase the production of cyclic AMP (cAMP) (Murad et al, 1969; Hollinger, 1970; Kuehl et al., 1970; Dorrington et al., 1972; Braun and Sepsenwol, 1974) and increase the synthesis of RNA and protein in the testis of the rat (Means and Hall, 1967, 1968, 1969; Goswami et al., 1968; D. Villee and Goswami, 1973). The increased synthesis of RNA and protein in response to gonadotropins is inhibited by pretreatment of the animals with actinomycin D (Means and Hall, 1969; Goswami et al., 1968; Reddy and Villee, 1975a). The ubiquitous distribution of the polyamines, their responses to hormonal stimuli, and their possible involvement in both transcriptional and translational events of cellular growth processes have been reported repeatedly and reviewed extensively (Williams-Ashman et al., 1972; Russell, 1973).

Keywords

Estrogen Cortisol Adenosine Testosterone Estradiol 

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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Claude A. Villee
    • 1
  • Janet M. Loring
    • 1
  1. 1.Department of Biological Chemistry and Laboratory of Human Reproduction and Reproductive BiologyHarvard Medical SchoolBostonUSA

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