Regulation of LH-RH Secretion by Gonadal Steroids and Catecholamines

  • Satya P. Kalra
  • Pushpa S. Kalra
  • J. W. Simpkins
Part of the Biochemical Endocrinology book series (BIOEND)


The presence of a hypothalamic factor that stimulates the release of pituitary luteinizing hormone (LH) was demonstrated two decades ago (McCann et al., 1960). A great deal of effort was directed toward the purification and chemical identification of the hypothalamic LH-releasing hormone (LH-RH). Matsuo et al. (1971) characterized the chemical structure of the naturally occurring LH-RH and showed it to be biologically and chemically identical with the synthetic decapeptide. Antibodies against the synthetic decapeptide were produced for the radioimmunoassay of LH-RH in tissue and body fluids (Nett et al.,1973). Recently, the distribution of the LH-RH neuronal network in the brain has been investigated by a variety of techniques including bioassay and radioimmunoassay and by immunocytochemical means (Naik, 1975; Elde and Hökfelt, 1978; Hoffman et al., 1978; Sétáló et al., 1978).


Luteinizing Hormone Preoptic Area Gonadal Steroid Luteinizing Hormone Surge Medial Preoptic Area 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Satya P. Kalra
    • 1
  • Pushpa S. Kalra
    • 1
  • J. W. Simpkins
    • 1
  1. 1.Department of Obstetrics and GynecologyUniversity of Florida College of MedicineGainesvilleUSA

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