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Regulation of LH-RH Secretion by Gonadal Steroids and Catecholamines

  • Satya P. Kalra
  • Pushpa S. Kalra
  • J. W. Simpkins
Part of the Biochemical Endocrinology book series (BIOEND)

Abstract

The presence of a hypothalamic factor that stimulates the release of pituitary luteinizing hormone (LH) was demonstrated two decades ago (McCann et al., 1960). A great deal of effort was directed toward the purification and chemical identification of the hypothalamic LH-releasing hormone (LH-RH). Matsuo et al. (1971) characterized the chemical structure of the naturally occurring LH-RH and showed it to be biologically and chemically identical with the synthetic decapeptide. Antibodies against the synthetic decapeptide were produced for the radioimmunoassay of LH-RH in tissue and body fluids (Nett et al.,1973). Recently, the distribution of the LH-RH neuronal network in the brain has been investigated by a variety of techniques including bioassay and radioimmunoassay and by immunocytochemical means (Naik, 1975; Elde and Hökfelt, 1978; Hoffman et al., 1978; Sétáló et al., 1978).

Keywords

Luteinizing Hormone Preoptic Area Gonadal Steroid Luteinizing Hormone Surge Medial Preoptic Area 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Satya P. Kalra
    • 1
  • Pushpa S. Kalra
    • 1
  • J. W. Simpkins
    • 1
  1. 1.Department of Obstetrics and GynecologyUniversity of Florida College of MedicineGainesvilleUSA

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