The Use of Isopropyl-N-phenylcarbamate as a Potential Contraceptive
The most successful contraceptive practices, exclusive of the physical methods, affect the complex hypothalamic—hypophyseal—gonadal feedback systems. The intervention could theoretically occur at any point of this feedback loop. Steroid supplementation reduces the level of gonadotrophin-secretory activity and via it gonadal steroid production. The inconveniences of this method to the user and the user’s undesirable physiological responses to this method have become known during recent decades of contraceptive practice (for a review, see Régulation de la Fécondité,Vol. 83, INSERM, Paris, 1979). Steroid-based contraceptives certainly influence gamete production and, as well, the hormone-secretory activity of the gonads themselves and various protein hormones of the central nervous system.
KeywordsNuclear Envelope Follicular Fluid Mouse Oocyte Nuclear Body Meiotic Spindle
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