Parturition, Lactation, and the Regulation of Oxytocin Receptors

  • Melvyn S. Soloff
  • Maria Alexandrova
Part of the Biochemical Endocrinology book series (BIOEND)


Modulation of hormone action can result from changes in the concentration of hormone receptors, as well as from changes in blood levels of the hormone. A number of studies have shown that target cells exposed to elevated concentrations of hormones develop reduced numbers of receptor sites for the hormones. In most systems studied, however, the changes in receptor concentration are not reflected physiologically by an altered response to the hormone. The oxytocin receptor is one of the exceptions. In this chapter, we will cite experimental evidence that supports the view that the actions of oxytocin on two of its targets—uterine smooth muscle and mammary myoepithelial cells—are regulated by the concentration of oxytocin receptors. This regulation appears to be important for the initiation of parturition and lactation in the rat. Factors that may play a role in regulating oxytocin-receptor concentration will be considered.


Estrogen Receptor Mammary Gland Endocrine Society Receptor Concentration Oxytocin Receptor 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Melvyn S. Soloff
    • 1
  • Maria Alexandrova
    • 2
  1. 1.Department of BiochemistryMedical College of OhioToledoUSA
  2. 2.Institute of Experimental EndocrinologySlovak Academy of SciencesBratislavaCzechoslovakia

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