Hormonal Control of Steroid Receptors in Human Endometrium during the Menstrual Cycle

  • Paul Robel
  • Rodrigue Mortel
  • Etienne-Emile Baulieu
Part of the Biochemical Endocrinology book series (BIOEND)


In the past two decades, the development of saturation-analysis methods has permitted specific and accurate measurements of circulating sex-steroid hormones, and their cyclic changes during the menstrual cycle are well documented. For the past ten years, a large body of evidence has been accumulated indicating that hormones interact with a receptor system before triggering cellular responses. Hormone receptors were first identified and physicochemically studied for steroids, particularly estradiol in the rat uterus. Once reliable measurements of hormone receptors became available in animal models, correlations were attempted between receptor concentrations and circulating levels of various hormones. It was discovered that the concentration of receptor molecules is not fixed, but varies with the physiological state of the animals. In particular, variations of the concentrations and subcellular distributions of receptors were observed during the estrous cycle and mimicked by injecting estradiol and progesterone into hormone-deprived animals (Bau-lieu et al., 1975).


Progesterone Receptor Receptor Site Human Endometrium Estradiol Receptor Human Uterus 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Paul Robel
    • 1
  • Rodrigue Mortel
    • 1
  • Etienne-Emile Baulieu
    • 1
  1. 1.Unité de Recherches sur le Métabolisme Moléculaire et la Physio-PathologieStéroides de l’Institut National de la Santé et de la Recherche Médicale (U 33 INSERM) and ER 125 CNRSBicêtreFrance

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